Site-specific antibody-drug conjugate heterogeneity characterization and heterogeneity root cause analysis

por Cao, Mingyan, De Mel, Niluka, Jiao, Yang, Howard, James, Parthemore, Conner, Korman, Samuel, Thompson, Christopher, Wendeler, Michaela, Liu, Dengfeng
Publicado 2019

Characterization of IgG1 Fc Deamidation at Asparagine 325 and Its Impact on Antibody-dependent Cell-mediated Cytotoxicity and FcγRIIIa Binding

por Lu, Xiaojun, Machiesky, Lee Ann, De Mel, Niluka, Du, Qun, Xu, Weichen, Washabaugh, Michael, Jiang, Xu-Rong, Wang, Jihong
Publicado 2020

Analytical characterization of coformulated antibodies as combination therapy

por Kim, Jun, Kim, Yoen Joo, Cao, Mingyan, De Mel, Niluka, Miller, Kenneth, Bee, Jared S., Wang, Jihong, Wang, Xiangyang, Albarghouthi, Methal
Publicado 2020

Multiplex Bioanalytical Methods for Comprehensive Characterization and Quantification of the Unique Complementarity-Determining-Region Deamidation of MEDI7247, an Anti-ASCT2 Pyrrol...

por Huang, Yue, Yuan, Jiaqi, Mu, Ruipeng, Kubiak, Robert J., Ball, Kathryn, Cao, Mingyan, Hussmann, G. Patrick, de Mel, Niluka, Liu, Dengfeng, Roskos, Lorin K., Liang, Meina, Rosenbaum, Anton I.
Publicado 2023

Charge variants characterization and release assay development for co-formulated antibodies as a combination therapy

por Cao, Mingyan, De Mel, Niluka, Shannon, Anthony, Prophet, Meagan, Wang, Chunlei, Xu, Weichen, Niu, Ben, Kim, Jun, Albarghouthi, Methal, Liu, Dengfeng, Meinke, Eric, Lin, Shihua, Wang, Xiangyang, Wang, Jihong
Publicado 2019

Atypical Asparagine Deamidation of NW Motif Significantly Attenuates the Biological Activities of an Antibody Drug Conjugate

por Cao, Mingyan, Hussmann, G. Patrick, Tao, Yeqing, O’Connor, Ellen, Parthemore, Conner, Zhang-Hulsey, Diana, Liu, Dengfeng, Jiao, Yang, de Mel, Niluka, Prophet, Meagan, Korman, Samuel, Sonawane, Jaytee, Grigoriadou, Christina, Huang, Yue, Umlauf, Scott, Chen, Xiaoyu
Publicado 2023