Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2‐deficient mice

por Zhou, Mei, Learned, R. Marc, Rossi, Stephen J., DePaoli, Alex M., Tian, Hui, Ling, Lei
Publicado 2016

Engineered FGF19 eliminates bile acid toxicity and lipotoxicity leading to resolution of steatohepatitis and fibrosis in mice

por Zhou, Mei, Learned, R. Marc, Rossi, Stephen J., DePaoli, Alex M., Tian, Hui, Ling, Lei
Publicado 2017

Therapeutic FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis

por Zhou, Mei, Learned, R. Marc, Rossi, Stephen J., Tian, Hui, DePaoli, Alex M., Ling, Lei
Publicado 2019

Recombinant Human Leptin Treatment Does Not Improve Insulin Action in Obese Subjects With Type 2 Diabetes

por Mittendorfer, Bettina, Horowitz, Jeffrey F., DePaoli, Alex M., McCamish, Mark A., Patterson, Bruce W., Klein, Samuel
Publicado 2011

The Commensal Microbe V eillonella as a Marker for Response to an FGF19 Analog in NASH

por Loomba, Rohit, Ling, Lei, Dinh, Duy M., DePaoli, Alex M., Lieu, Hsiao D., Harrison, Stephen A., Sanyal, Arun J.
Publicado 2020

Potent suppression of hydrophobic bile acids by aldafermin, an FGF19 analogue, across metabolic and cholestatic liver diseases

por Sanyal, Arun J., Ling, Lei, Beuers, Ulrich, DePaoli, Alex M., Lieu, Hsiao D., Harrison, Stephen A., Hirschfield, Gideon M.
Publicado 2021

Circulating Citrate Is Associated with Liver Fibrosis in Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

por Amjad, Waseem, Shalaurova, Irina, Garcia, Erwin, Gruppen, Eke G., Dullaart, Robin P. F., DePaoli, Alex M., Jiang, Z. Gordon, Lai, Michelle, Connelly, Margery A.
Publicado 2023

NGM282 for Treatment of Patients With Primary Biliary Cholangitis: A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Trial

por Mayo, Marlyn J., Wigg, Alan J., Leggett, Barbara A., Arnold, Hays, Thompson, Alexander J., Weltman, Martin, Carey, Elizabeth J., Muir, Andrew J., Ling, Lei, Rossi, Stephen J., DePaoli, Alex M.
Publicado 2018

NGM282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients With Nonalcoholic Steatohepatitis

por Harrison, Stephen A., Rossi, Stephen J., Paredes, Angelo H., Trotter, James F., Bashir, Mustafa R., Guy, Cynthia D., Banerjee, Rajarshi, Jaros, Mark J., Owers, Sandra, Baxter, Bryan A., Ling, Lei, DePaoli, Alex M.
Publicado 2019

Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance

por Moon, Hyun-Seuk, Matarese, Giuseppe, Brennan, Aoife M., Chamberland, John P., Liu, Xiaowen, Fiorenza, Christina G., Mylvaganam, Geetha H., Abanni, Luisa, Carbone, Fortunata, Williams, Catherine J., De Paoli, Alex M., Schneider, Benjamin E., Mantzoros, Christos S.
Publicado 2011