Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies

por Fultang, Livingstone, Gneo, Luciana, De Santo, Carmela, Mussai, Francis J.
Publicado 2021

Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies

por Vardon, Ashley, Dandapani, Madhumita, Cheng, Daryl, Cheng, Paul, De Santo, Carmela, Mussai, Francis
Publicado 2017

Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma

por De Santo, Carmela, Cheng, Paul, Beggs, Andrew, Egan, Sharon, Bessudo, Alberto, Mussai, Francis
Publicado 2018

TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer

por Gneo, Luciana, Rizkalla, Nagy, Hejmadi, Rahul, Mussai, Francis, de Santo, Carmela, Middleton, Gary
Publicado 2021

Invariant NKT cells modulate the suppressive activity of Serum Amyloid A-differentiated IL-10-secreting neutrophils

por De Santo, Carmela, Arscott, Ramon, Booth, Sarah, Karydis, Ioannis, Jones, Margaret, Asher, Ruth, Salio, Mariolina, Middleton, Mark, Cerundolo, Vincenzo
Publicado 2010

Targeting the arginine metabolic brake enhances immunotherapy for leukaemia

por Mussai, Francis, Wheat, Rachel, Sarrou, Evgenia, Booth, Sarah, Stavrou, Victoria, Fultang, Livingstone, Perry, Tracey, Kearns, Pamela, Cheng, Paul, Keeshan, Karen, Craddock, Charles, De Santo, Carmela
Publicado 2019

G‐CSF induces CD15(+) CD14(+) cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment

por Maneta, Ebtehag, Fultang, Livingstone, Taylor, Jemma, Pugh, Matthew, Jenkinson, William, Anderson, Graham, Coomarasamy, Arri, Kilby, Mark D, Lissauer, David M, Mussai, Francis, De Santo, Carmela
Publicado 2022

The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated‐recombinant arginase I BCT‐100

por De Santo, Carmela, Booth, Sarah, Vardon, Ashley, Cousins, Antony, Tubb, Vanessa, Perry, Tracey, Noyvert, Boris, Beggs, Andrew, Ng, Margaret, Halsey, Christina, Kearns, Pamela, Cheng, Paul, Mussai, Francis
Publicado 2017

Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy

por Bokori-Brown, Monika, Metz, Jeremy, Petrov, Peter G., Mussai, Francis, De Santo, Carmela, Smart, Neil J., Saunders, Sarah, Knight, Bridget, Pastan, Ira, Titball, Richard W., Winlove, C. Peter
Publicado 2018

MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers

por Fultang, Livingstone, Panetti, Silvia, Ng, Margaret, Collins, Paul, Graef, Suzanne, Rizkalla, Nagy, Booth, Sarah, Lenton, Richard, Noyvert, Boris, Shannon-Lowe, Claire, Middleton, Gary, Mussai, Francis, De Santo, Carmela
Publicado 2019

Combination Lenalidomide and Azacitidine: A Novel Salvage Therapy in Patients Who Relapse After Allogeneic Stem-Cell Transplantation for Acute Myeloid Leukemia

por Craddock, Charles, Slade, Daniel, De Santo, Carmela, Wheat, Rachel, Ferguson, Paul, Hodgkinson, Andrea, Brock, Kristian, Cavenagh, Jamie, Ingram, Wendy, Dennis, Mike, Malladi, Ram, Siddique, Shamyla, Mussai, Francis, Yap, Christina
Publicado 2019

Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment

por Panetti, Silvia, McJannett, Nicola, Fultang, Livingstone, Booth, Sarah, Gneo, Luciana, Scarpa, Ugo, Smith, Charles, Vardon, Ashley, Vettore, Lisa, Whalley, Celina, Pan, Yi, Várnai, Csilla, Endou, Hitoshi, Barlow, Jonathan, Tennant, Daniel, Beggs, Andrew, Mussai, Francis, De Santo, Carmela
Publicado 2022

Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment

por Stavrou, Victoria, Fultang, Livingstone, Booth, Sarah, De Simone, Daniele, Bartnik, Arekdiusz, Scarpa, Ugo, Gneo, Luciana, Panetti, Silvia, Potluri, Sandeep, Almowaled, Meaad, Barlow, Jonathan, Jankevics, Andris, Lloyd, Gavin, Southam, Andrew, Priestman, David A., Cheng, Paul, Dunn, Warwick, Platt, Frances, Endou, Hitoshi, Craddock, Charles, Keeshan, Karen, Mussai, Francis, De Santo, Carmela
Publicado 2022