A Hidden Markov Model for identifying essential and growth-defect regions in bacterial genomes from transposon insertion sequencing data

por DeJesus, Michael A, Ioerger, Thomas R
Publicado 2013

TRANSIT - A Software Tool for Himar1 TnSeq Analysis

por DeJesus, Michael A., Ambadipudi, Chaitra, Baker, Richard, Sassetti, Christopher, Ioerger, Thomas R.
Publicado 2015

A dose-response based model for statistical analysis of chemical genetic interactions in CRISPRi libraries

por Choudhery, Sanjeevani, DeJesus, Michael A., Srinivasan, Aarthi, Rock, Jeremy, Schnappinger, Dirk, Ioerger, Thomas R.
Publicado 2023

Behavioral and transcriptomic profiling of mice null for Lphn3, a gene implicated in ADHD and addiction

por Orsini, Caitlin A., Setlow, Barry, DeJesus, Michael, Galaviz, Stacy, Loesch, Kimberly, Ioerger, Thomas, Wallis, Deeann
Publicado 2016

Statistical analysis of genetic interactions in Tn-Seq data

por DeJesus, Michael A., Nambi, Subhalaxmi, Smith, Clare M., Baker, Richard E., Sassetti, Christopher M., Ioerger, Thomas R.
Publicado 2017

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

por Griffin, Jennifer E., Gawronski, Jeffrey D., DeJesus, Michael A., Ioerger, Thomas R., Akerley, Brian J., Sassetti, Christopher M.
Publicado 2011

An improved statistical method to identify chemical-genetic interactions by exploiting concentration-dependence

por Dutta, Esha, DeJesus, Michael A., Ruecker, Nadine, Zaveri, Anisha, Koh, Eun-Ik, Sassetti, Christopher M., Schnappinger, Dirk, Ioerger, Thomas R.
Publicado 2021

Functional Genomics Screening Utilizing Mutant Mouse Embryonic Stem Cells Identifies Novel Radiation-Response Genes

por Loesch, Kimberly, Galaviz, Stacy, Hamoui, Zaher, Clanton, Ryan, Akabani, Gamal, Deveau, Michael, DeJesus, Michael, Ioerger, Thomas, Sacchettini, James C., Wallis, Deeann
Publicado 2015

Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression

por Subramaniyam, Siddharth, DeJesus, Michael A., Zaveri, Anisha, Smith, Clare M., Baker, Richard E., Ehrt, Sabine, Schnappinger, Dirk, Sassetti, Christopher M., Ioerger, Thomas R.
Publicado 2019

Beyond antibiotic resistance: the whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria

por Poulton, Nicholas C., DeJesus, Michael A., Munsamy-Govender, Vanisha, Roberts, Cameron G., Azadian, Zachary A., Bosch, Barbara, Lin, Karl Matthew, Li, Shuqi, Rock, Jeremy M.
Publicado 2023

CRISPR Interference Reveals That All-Trans-Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzym...

por Babunovic, Gregory H., DeJesus, Michael A., Bosch, Barbara, Chase, Michael R., Barbier, Thibault, Dickey, Amy K., Bryson, Bryan D., Rock, Jeremy M., Fortune, Sarah M.
Publicado 2022

Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice

por Korte, Jan, Alber, Marina, Trujillo, Carolina M., Syson, Karl, Koliwer-Brandl, Hendrik, Deenen, René, Köhrer, Karl, DeJesus, Michael A., Hartman, Travis, Jacobs, William R., Bornemann, Stephen, Ioerger, Thomas R., Ehrt, Sabine, Kalscheuer, Rainer
Publicado 2016

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis

por DeJesus, Michael A., Gerrick, Elias R., Xu, Weizhen, Park, Sae Woong, Long, Jarukit E., Boutte, Cara C., Rubin, Eric J., Schnappinger, Dirk, Ehrt, Sabine, Fortune, Sarah M., Sassetti, Christopher M., Ioerger, Thomas R.
Publicado 2017

Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis

por Bosch, Barbara, DeJesus, Michael A., Poulton, Nicholas C., Zhang, Wenzhu, Engelhart, Curtis A., Zaveri, Anisha, Lavalette, Sophie, Ruecker, Nadine, Trujillo, Carolina, Wallach, Joshua B., Li, Shuqi, Ehrt, Sabine, Chait, Brian T., Schnappinger, Dirk, Rock, Jeremy M.
Publicado 2021

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

por Li, Shuqi, Poulton, Nicholas C., Chang, Jesseon S., Azadian, Zachary A., DeJesus, Michael A., Ruecker, Nadine, Zimmerman, Matthew D., Eckartt, Kathryn A., Bosch, Barbara, Engelhart, Curtis A., Sullivan, Daniel F., Gengenbacher, Martin, Dartois, Véronique A., Schnappinger, Dirk, Rock, Jeremy M.
Publicado 2022