The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival

por Combs, Joseph A., DeNicola, Gina M.
Publicado 2019

Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer

por DeBlasi, Janine M., DeNicola, Gina M.
Publicado 2020

Recent advances in cancer metabolism: a technological perspective

por Kang, Yun Pyo, Ward, Nathan P., DeNicola, Gina M.
Publicado 2018

The utility of transposon mutagenesis for cancer studies in the era of genome editing

por DeNicola, Gina M., Karreth, Florian A., Adams, David J., Wong, Chi C.
Publicado 2015

Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function

por Ward, Nathan P., Kang, Yun Pyo, Falzone, Aimee, Boyle, Theresa A., DeNicola, Gina M.
Publicado 2020

Genetic tools for the stable overexpression of circular RNAs

por Mecozzi, Nicol, Nenci, Arianna, Vera, Olga, Bok, Ilah, Falzone, Aimee, DeNicola, Gina M., Karreth, Florian A.
Publicado 2022

Corrigendum to “A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer” [Redox Biol. 54 (2022) 102358]

por Jiang, Chang, Ward, Nathan P., Prieto-Farigua, Nicolas, Kang, Yun Pyo, Thalakola, Anish, Teng, Mingxiang, DeNicola, Gina M.
Publicado 2022

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone

por Torrente, Laura, Prieto-Farigua, Nicolas, Falzone, Aimee, Elkins, Cody M., Boothman, David A., Haura, Eric B., DeNicola, Gina M.
Publicado 2020

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

por Cheung, Eric C., DeNicola, Gina M., Nixon, Colin, Blyth, Karen, Labuschagne, Christiaan F., Tuveson, David A., Vousden, Karen H.
Publicado 2020

Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

por Kang, Yun Pyo, Torrente, Laura, Falzone, Aimee, Elkins, Cody M, Liu, Min, Asara, John M, Dibble, Christian C, DeNicola, Gina M
Publicado 2019

Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors

por Yoon, Sang Jun, Combs, Joseph A., Falzone, Aimee, Prieto-Farigua, Nicolas, Caldwell, Samantha, Ackerman, Hayley D., Flores, Elsa R., DeNicola, Gina M.
Publicado 2023

PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

por Kang, Yun Pyo, Falzone, Aimee, Liu, Min, González-Sánchez, Paloma, Choi, Bo-Hyun, Coloff, Jonathan L., Saller, James J., Karreth, Florian A., DeNicola, Gina M.
Publicado 2020

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

por DeBlasi, Janine M., Falzone, Aimee, Caldwell, Samantha, Prieto-Farigua, Nicolas, Prigge, Justin R., Schmidt, Edward E., Chio, Iok In Christine, Karreth, Florian A., DeNicola, Gina M.
Publicado 2023

Oxidation state-specific fluorescent copper sensors reveal oncogene-driven redox changes that regulate labile copper(II) pools

por Pezacki, Aidan T., Matier, Carson D., Gu, Xingxing, Kummelstedt, Eric, Bond, Sarah E., Torrente, Laura, Jordan-Sciutto, Kelly L., DeNicola, Gina M., Su, Timothy A., Brady, Donita C., Chang, Christopher J.
Publicado 2022

NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis

por Ilter, Didem, Drapela, Stanislav, Schild, Tanya, Ward, Nathan P., Adhikari, Emma, Low, Vivien, Asara, John, Oskarsson, Thordur, Lau, Eric K., DeNicola, Gina M., McReynolds, Melanie R., Gomes, Ana P.
Publicado 2023

ASCT2 is the primary serine transporter in cancer cells

por Conger, Kelly O., Chidley, Christopher, Ozgurses, Mete Emir, Zhao, Huiping, Kim, Yumi, Semina, Svetlana E., Burns, Philippa, Rawat, Vipin, Sheldon, Ryan, Ben-Sahra, Issam, Frasor, Jonna, Sorger, Peter K., DeNicola, Gina M., Coloff, Jonathan L.
Publicado 2023

NRF2 regulates serine biosynthesis in non-small cell lung cancer

por DeNicola, Gina M., Chen, Pei-Hsuan, Mullarky, Edouard, Sudderth, Jessica A., Hu, Zeping, Wu, David, Tang, Hao, Xie, Yang, Asara, John M., Huffman, Kenneth E., Wistuba, Ignacio I., Minna, John D., DeBerardinis, Ralph J., Cantley, Lewis C.
Publicado 2015

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

por DeNicola, Gina M., Karreth, Florian A., Humpton, Timothy J., Gopinathan, Aarthi, Wei, Cong, Frese, Kristopher, Mangal, Dipti, Yu, Kenneth H., Yeo, Charles J., Calhoun, Eric S., Scrimieri, Francesca, Winter, Jordan M., Hruban, Ralph H., Iacobuzio-Donahue, Christine, Kern, Scott E., Blair, Ian A., Tuveson, David A.
Publicado 2011

Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy

por Rawat, Vipin, DeLear, Patrick, Prashanth, Prarthana, Ozgurses, Mete Emir, Tebeje, Anteneh, Burns, Philippa A., Conger, Kelly O., Solís, Christopher, Hasnain, Yasir, Novikova, Anna, Endress, Jennifer E., González-Sánchez, Paloma, Dong, Wentao, Stephanopoulos, Greg, DeNicola, Gina M., Harris, Isaac S., Sept, David, Mason, Frank M., Coloff, Jonathan L.
Publicado 2023

On the illusion of auxotrophy: met15Δ yeast cells can grow on inorganic sulfur, thanks to the previously uncharacterized homocysteine synthase Yll058w

por Van Oss, S. Branden, Parikh, Saurin Bipin, Castilho Coelho, Nelson, Wacholder, Aaron, Belashov, Ivan, Zdancewicz, Sara, Michaca, Manuel, Xu, Jiazhen, Kang, Yun Pyo, Ward, Nathan P., Yoon, Sang Jun, McCourt, Katherine M., McKee, Jake, Ideker, Trey, VanDemark, Andrew P., DeNicola, Gina M., Carvunis, Anne-Ruxandra
Publicado 2022