Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening

por DeWeirdt, Peter C., McGee, Abby V., Zheng, Fengyi, Nwolah, Ifunanya, Hegde, Mudra, Doench, John G.
Publicado 2022

Genetic screens in isogenic mammalian cell lines without single cell cloning

por DeWeirdt, Peter C., Sangree, Annabel K., Hanna, Ruth E., Sanson, Kendall R., Hegde, Mudra, Strand, Christine, Persky, Nicole S., Doench, John G.
Publicado 2020

Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2

por Sangree, Annabel K., Griffith, Audrey L., Szegletes, Zsofia M., Roy, Priyanka, DeWeirdt, Peter C., Hegde, Mudra, McGee, Abby V., Hanna, Ruth E., Doench, John G.
Publicado 2022

Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells

por Lenoir, W. Frank, Morgado, Micaela, DeWeirdt, Peter C., McLaughlin, Megan, Griffith, Audrey L., Sangree, Annabel K., Feeley, Marissa N., Esmaeili Anvar, Nazanin, Kim, Eiru, Bertolet, Lori L., Colic, Medina, Dede, Merve, Doench, John G., Hart, Traver
Publicado 2021

Optimization of AsCas12a for combinatorial genetic screens in human cells

por DeWeirdt, Peter C, Sanson, Kendall R, Sangree, Annabel K, Hegde, Mudra, Hanna, Ruth E, Feeley, Marissa N, Griffith, Audrey L, Teng, Teng, Borys, Samantha M, Strand, Christine, Joung, J Keith, Kleinstiver, Benjamin P, Pan, Xuewen, Huang, Alan, Doench, John G
Publicado 2020

Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions

por Flynn, Ryan A., Belk, Julia A., Qi, Yanyan, Yasumoto, Yuki, Wei, Jin, Alfajaro, Mia Madel, Shi, Quanming, Mumbach, Maxwell R., Limaye, Aditi, DeWeirdt, Peter C., Schmitz, Cameron O., Parker, Kevin R., Woo, Elizabeth, Chang, Howard Y., Horvath, Tamas L., Carette, Jan E., Bertozzi, Carolyn R., Wilen, Craig B., Satpathy, Ansuman T.
Publicado 2021

DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner

por Strine, Madison S., Cai, Wesley L., Wei, Jin, Alfajaro, Mia Madel, Filler, Renata B., Biering, Scott B., Sarnik, Sylvia, Chow, Ryan D., Patil, Ajinkya, Cervantes, Kasey S., Collings, Clayton K., DeWeirdt, Peter C., Hanna, Ruth E., Schofield, Kevin, Hulme, Christopher, Konermann, Silvana, Doench, John G., Hsu, Patrick D., Kadoch, Cigall, Yan, Qin, Wilen, Craig B.
Publicado 2023

Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection

por Wei, Jin, Patil, Ajinkya, Collings, Clayton K., Alfajaro, Mia Madel, Liang, Yu, Cai, Wesley L., Strine, Madison S., Filler, Renata B., DeWeirdt, Peter C., Hanna, Ruth E., Menasche, Bridget L., Ökten, Arya, Peña-Hernández, Mario A., Klein, Jon, McNamara, Andrew, Rosales, Romel, McGovern, Briana L., Luis Rodriguez, M., García-Sastre, Adolfo, White, Kris M., Qin, Yiren, Doench, John G., Yan, Qin, Iwasaki, Akiko, Zwaka, Thomas P., Qi, Jun, Kadoch, Cigall, Wilen, Craig B.
Publicado 2023

Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

por Wei, Jin, Alfajaro, Mia Madel, Hanna, Ruth E., DeWeirdt, Peter C., Strine, Madison S., Lu-Culligan, William J., Zhang, Shang-Min, Graziano, Vincent R., Schmitz, Cameron O., Chen, Jennifer S., Mankowski, Madeleine C., Filler, Renata B., Gasque, Victor, de Miguel, Fernando, Chen, Huacui, Oguntuyo, Kasopefoluwa, Abriola, Laura, Surovtseva, Yulia V., Orchard, Robert C., Lee, Benhur, Lindenbach, Brett, Politi, Katerina, van Dijk, David, Simon, Matthew D., Yan, Qin, Doench, John G., Wilen, Craig B.
Publicado 2020

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

por Wei, Jin, Alfajaro, Mia Madel, DeWeirdt, Peter C., Hanna, Ruth E., Lu-Culligan, William J., Cai, Wesley L., Strine, Madison S., Zhang, Shang-Min, Graziano, Vincent R., Schmitz, Cameron O., Chen, Jennifer S., Mankowski, Madeleine C., Filler, Renata B., Ravindra, Neal G., Gasque, Victor, de Miguel, Fernando J., Patil, Ajinkya, Chen, Huacui, Oguntuyo, Kasopefoluwa Y., Abriola, Laura, Surovtseva, Yulia V., Orchard, Robert C., Lee, Benhur, Lindenbach, Brett D., Politi, Katerina, van Dijk, David, Kadoch, Cigall, Simon, Matthew D., Yan, Qin, Doench, John G., Wilen, Craig B.
Publicado 2021