Structural insight into FANCI–FANCD2 monoubiquitination

por Li, Landing, Tan, Winnie, Deans, Andrew J.
Publicado 2020

Protein truncating variants in FANCM and risk for ER-negative/triple negative breast cancer

por Peterlongo, Paolo, Figlioli, Gisella, Deans, Andrew J., Couch, Fergus J.
Publicado 2021

ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2

por Tan, Winnie, van Twest, Sylvie, Murphy, Vincent J., Deans, Andrew J.
Publicado 2020

ALT control, delete: FANCM as an anti-cancer target in Alternative Lengthening of Telomeres

por O’Rourke, Julienne J, Bythell-Douglas, Rohan, Dunn, Elyse A, Deans, Andrew J
Publicado 2019

ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress

por Liu, Rui, King, Ashleigh, Hoch, Nicolas C., Chang, Catherine, Kelly, Gemma L., Deans, Andrew J., Heierhorst, Jörg
Publicado 2017

Architecture and DNA Recognition Elements of the Fanconi Anemia FANCM-FAAP24 Complex

por Coulthard, Rachel, Deans, Andrew J., Swuec, Paolo, Bowles, Maureen, Costa, Alessandro, West, Stephen C., McDonald, Neil Q.
Publicado 2013

The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair

por Vuono, Elizabeth A., Mukherjee, Ananda, Vierra, David A., Adroved, Morganne M., Hodson, Charlotte, Deans, Andrew J., Howlett, Niall G.
Publicado 2016

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4

por Castillo-Tandazo, Wilson, Smeets, Monique F., Murphy, Vincent, Liu, Rui, Hodson, Charlotte, Heierhorst, Jörg, Deans, Andrew J., Walkley, Carl R.
Publicado 2019

Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex

por Sharp, Michael F., Murphy, Vince J., Twest, Sylvie Van, Tan, Winnie, Lui, Jennii, Simpson, Kaylene J., Deans, Andrew J., Crismani, Wayne
Publicado 2020

The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2

por Swuec, Paolo, Renault, Ludovic, Borg, Aaron, Shah, Fenil, Murphy, Vincent J., van Twest, Sylvie, Snijders, Ambrosius P., Deans, Andrew J., Costa, Alessandro
Publicado 2016

FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

por Silva, Bruno, Pentz, Richard, Figueira, Ana Margarida, Arora, Rajika, Lee, Yong Woo, Hodson, Charlotte, Wischnewski, Harry, Deans, Andrew J., Azzalin, Claus M.
Publicado 2019

Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

por Tan, Winnie, van Twest, Sylvie, Leis, Andrew, Bythell-Douglas, Rohan, Murphy, Vincent J, Sharp, Michael, Parker, Michael W, Crismani, Wayne, Deans, Andrew J
Publicado 2020

Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin

por Tan, Winnie, Murphy, Vincent J., Charron, Aude, van Twest, Sylvie, Sharp, Michael, Constantinou, Angelos, Parker, Michael W., Crismani, Wayne, Bythell-Douglas, Rohan, Deans, Andrew J.
Publicado 2020

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

por Schwab, Rebekka A., Nieminuszczy, Jadwiga, Shah, Fenil, Langton, Jamie, Lopez Martinez, David, Liang, Chih-Chao, Cohn, Martin A., Gibbons, Richard J., Deans, Andrew J., Niedzwiedz, Wojciech
Publicado 2015

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

por Lu, Robert, O’Rourke, Julienne J., Sobinoff, Alexander P., Allen, Joshua A. M., Nelson, Christopher B., Tomlinson, Christopher G., Lee, Michael, Reddel, Roger R., Deans, Andrew J., Pickett, Hilda A.
Publicado 2019

Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

por Lu, Robert, O’Rourke, Julienne J., Sobinoff, Alexander P., Allen, Joshua A. M., Nelson, Christopher B., Tomlinson, Christopher G., Lee, Michael, Reddel, Roger R., Deans, Andrew J., Pickett, Hilda A.
Publicado 2019

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability

por Hodson, Charlotte, Low, Jason K. K., van Twest, Sylvie, Jones, Samuel E., Swuec, Paolo, Murphy, Vincent, Tsukada, Kaima, Fawkes, Matthew, Bythell-Douglas, Rohan, Davies, Adelina, Holien, Jessica K., O’Rourke, Julienne J., Parker, Benjamin L., Glaser, Astrid, Parker, Michael W., Mackay, Joel P., Blackford, Andrew N., Costa, Alessandro, Deans, Andrew J.
Publicado 2022

Fancm has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals

por Tsui, Vanessa, Lyu, Ruqian, Novakovic, Stevan, Stringer, Jessica M., Dunleavy, Jessica E.M., Granger, Elissah, Semple, Tim, Leichter, Anna, Martelotto, Luciano G., Merriner, D. Jo, Liu, Ruijie, McNeill, Lucy, Zerafa, Nadeen, Hoffmann, Eva R., O’Bryan, Moira K., Hutt, Karla, Deans, Andrew J., Heierhorst, Jörg, McCarthy, Davis J., Crismani, Wayne
Publicado 2023

Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia

por Maung, Kyaw Ze Ya, Leo, Paul J., Bassal, Mahmoud, Casolari, Debora A., Gray, James X, Bray, Sarah C., Pederson, Stephen, Singhal, Deepak, Samaraweera, Saumya E., Nguyen, Tran, Cildir, Gökhan, Marshall, Mhairi, Ewing, Adam, Duncan, Emma L., Brown, Matthew A., Saal, Russell, Tergaonkar, Vinay, To, Luen Bik, Marlton, Paula, Gill, Devinder, Lewis, Ian, Deans, Andrew J, Brown, Anna L, D’Andrea, Richard J, Gonda, Thomas J
Publicado 2018

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

por Sanij, Elaine, Hannan, Katherine M., Xuan, Jiachen, Yan, Shunfei, Ahern, Jessica E., Trigos, Anna S., Brajanovski, Natalie, Son, Jinbae, Chan, Keefe T., Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Deans, Andrew J., Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M. J. J., Hannan, Ross D., Scott, Clare L., Sheppard, Karen E., Pearson, Richard B.
Publicado 2020