Role of Hydrophobicity at the N-Terminal Region of Aβ42 in Secondary Nucleation

por Thacker, Dev, Willas, Amanda, Dear, Alexander J., Linse, Sara
Publicado 2022

Amyloid-β peptide 37, 38 and 40 individually and cooperatively inhibit amyloid-β 42 aggregation

por Braun, Gabriel A., Dear, Alexander J., Sanagavarapu, Kalyani, Zetterberg, Henrik, Linse, Sara
Publicado 2022

Oligomer Diversity during the Aggregation of the Repeat Region of Tau

por Kjaergaard, Magnus, Dear, Alexander J., Kundel, Franziska, Qamar, Seema, Meisl, Georg, Knowles, Tuomas P. J., Klenerman, David
Publicado 2018

The catalytic nature of protein aggregation

por Dear, Alexander J., Meisl, Georg, Michaels, Thomas C. T., Zimmermann, Manuela R., Linse, Sara, Knowles, Tuomas P. J.
Publicado 2020

Identification of on- and off-pathway oligomers in amyloid fibril formation

por Dear, Alexander J., Meisl, Georg, Šarić, Anđela, Michaels, Thomas C. T., Kjaergaard, Magnus, Linse, Sara, Knowles, Tuomas P. J.
Publicado 2020

Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2

por Yang, Jie, Dear, Alexander J., Michaels, Thomas C. T., Dobson, Christopher M., Knowles, Tuomas P. J., Wu, Si, Perrett, Sarah
Publicado 2018

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants

por Tosatto, Laura, Horrocks, Mathew H., Dear, Alexander J., Knowles, Tuomas P. J., Dalla Serra, Mauro, Cremades, Nunilo, Dobson, Christopher M., Klenerman, David
Publicado 2015

In situ kinetic measurements of α-synuclein aggregation reveal large population of short-lived oligomers

por Zurlo, Enrico, Kumar, Pravin, Meisl, Georg, Dear, Alexander J., Mondal, Dipro, Claessens, Mireille M. A. E., Knowles, Tuomas P. J., Huber, Martina
Publicado 2021

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species

por Sang, Jason C., Lee, Ji-Eun, Dear, Alexander J., De, Suman, Meisl, Georg, Thackray, Alana M., Bujdoso, Raymond, Knowles, Tuomas P. J., Klenerman, David
Publicado 2019

Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms

por Iljina, Marija, Garcia, Gonzalo A., Dear, Alexander J., Flint, Jennie, Narayan, Priyanka, Michaels, Thomas C. T., Dobson, Christopher M., Frenkel, Daan, Knowles, Tuomas P. J., Klenerman, David
Publicado 2016

Quantifying Co-Oligomer Formation by α-Synuclein

por Iljina, Marija, Dear, Alexander J., Garcia, Gonzalo A., De, Suman, Tosatto, Laura, Flagmeier, Patrick, Whiten, Daniel R., Michaels, Thomas C. T., Frenkel, Daan, Dobson, Christopher M., Knowles, Tuomas P. J., Klenerman, David
Publicado 2018