Understanding Ligand Binding Selectivity in a Prototypical GPCR Family

por Mattedi, Giulio, Deflorian, Francesca, Mason, Jonathan S., de Graaf, Chris, Gervasio, Francesco L.
Publicado 2019

High end GPCR design: crafted ligand design and druggability analysis using protein structure, lipophilic hotspots and explicit water networks

por Mason, Jonathan S, Bortolato, Andrea, Weiss, Dahlia R, Deflorian, Francesca, Tehan, Benjamin, Marshall, Fiona H
Publicado 2013

Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: A complete structure–activity profile

por Cacciari, Barbara, Bolcato, Chiara, Spalluto, Giampiero, Klotz, Karl-Norbet, Bacilieri, Magdalena, Deflorian, Francesca, Moro, Stefano
Publicado 2006

X‐Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A(2A) Adenosine Receptor Antagonists

por Jespers, Willem, Verdon, Grégory, Azuaje, Jhonny, Majellaro, Maria, Keränen, Henrik, García‐Mera, Xerardo, Congreve, Miles, Deflorian, Francesca, de Graaf, Chris, Zhukov, Andrei, Doré, Andrew S., Mason, Jonathan S., Åqvist, Johan, Cooke, Robert M., Sotelo, Eddy, Gutiérrez‐de‐Terán, Hugo
Publicado 2020