Cryo‐EM structure of metazoan TRAPPIII, the multi‐subunit complex that activates the GTPase Rab1

por Galindo, Antonio, Planelles‐Herrero, Vicente J, Degliesposti, Gianluca, Munro, Sean
Publicado 2021

Structures of Respiratory Supercomplex I+III(2) Reveal Functional and Conformational Crosstalk

por Letts, James A., Fiedorczuk, Karol, Degliesposti, Gianluca, Skehel, Mark, Sazanov, Leonid A.
Publicado 2019

Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin

por Holzer, Sandro, Degliesposti, Gianluca, Kilkenny, Mairi L., Maslen, Sarah L., Matak-Vinkovíc, Dijana, Skehel, Mark, Pellegrini, Luca
Publicado 2017

Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin

por Holzer, Sandro, Degliesposti, Gianluca, Kilkenny, Mairi L, Maslen, Sarah L, Matak-Vinkovíc, Dijana, Skehel, Mark, Pellegrini, Luca
Publicado 2020

CryoEM of RUVBL1–RUVBL2–ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8

por Serna, Marina, González-Corpas, Ana, Cabezudo, Sofía, López-Perrote, Andrés, Degliesposti, Gianluca, Zarzuela, Eduardo, Skehel, J Mark, Muñoz, Javier, Llorca, Oscar
Publicado 2021

WISDOM-II: Screening against multiple targets implicated in malaria using computational grid infrastructures

por Kasam, Vinod, Salzemann, Jean, Botha, Marli, Dacosta, Ana, Degliesposti, Gianluca, Isea, Raul, Kim, Doman, Maass, Astrid, Kenyon, Colin, Rastelli, Giulio, Hofmann-Apitius, Martin, Breton, Vincent
Publicado 2009

The Structure of the R2TP Complex Defines a Platform for Recruiting Diverse Client Proteins to the HSP90 Molecular Chaperone System

por Rivera-Calzada, Angel, Pal, Mohinder, Muñoz-Hernández, Hugo, Luque-Ortega, Juan R., Gil-Carton, David, Degliesposti, Gianluca, Skehel, J. Mark, Prodromou, Chrisostomos, Pearl, Laurence H., Llorca, Oscar
Publicado 2017

Activation of the Endonuclease that Defines mRNA 3′ Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex

por Hill, Chris H., Boreikaitė, Vytautė, Kumar, Ananthanarayanan, Casañal, Ana, Kubík, Peter, Degliesposti, Gianluca, Maslen, Sarah, Mariani, Angelica, von Loeffelholz, Ottilie, Girbig, Mathias, Skehel, Mark, Passmore, Lori A.
Publicado 2019

Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone

por Pal, Mohinder, Muñoz-Hernandez, Hugo, Bjorklund, Dennis, Zhou, Lihong, Degliesposti, Gianluca, Skehel, J. Mark, Hesketh, Emma L., Thompson, Rebecca F., Pearl, Laurence H., Llorca, Oscar, Prodromou, Chrisostomos
Publicado 2021

Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins

por Malvezzi, Francesca, Stubbs, Christopher J., Jowitt, Thomas A., Dale, Ian L., Guo, Xieyang, DeGnore, Jon P., Degliesposti, Gianluca, Skehel, J. Mark, Bannister, Andrew J., McAlister, Mark S.
Publicado 2021

Inter-membrane association of the Sec and BAM translocons for bacterial outer-membrane biogenesis

por Alvira, Sara, Watkins, Daniel W, Troman, Lucy, Allen, William J, Lorriman, James S, Degliesposti, Gianluca, Cohen, Eli J, Beeby, Morgan, Daum, Bertram, Gold, Vicki AM, Skehel, J Mark, Collinson, Ian
Publicado 2020

RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex

por Martino, Fabrizio, Pal, Mohinder, Muñoz-Hernández, Hugo, Rodríguez, Carlos F., Núñez-Ramírez, Rafael, Gil-Carton, David, Degliesposti, Gianluca, Skehel, J. Mark, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence H., Llorca, Oscar
Publicado 2018

Author Correction: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex

por Martino, Fabrizio, Pal, Mohinder, Muñoz-Hernández, Hugo, Rodríguez, Carlos F., Núñez-Ramírez, Rafael, Gil-Carton, David, Degliesposti, Gianluca, Skehel, J. Mark, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence H., Llorca, Oscar
Publicado 2018

Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch

por Lehmann, Laura C., Bacic, Luka, Hewitt, Graeme, Brackmann, Klaus, Sabantsev, Anton, Gaullier, Guillaume, Pytharopoulou, Sofia, Degliesposti, Gianluca, Okkenhaug, Hanneke, Tan, Song, Costa, Alessandro, Skehel, J. Mark, Boulton, Simon J., Deindl, Sebastian
Publicado 2020

Architecture of eukaryotic mRNA 3′-end processing machinery

por Casañal, Ana, Kumar, Ananthanarayanan, Hill, Chris H., Easter, Ashley D., Emsley, Paul, Degliesposti, Gianluca, Gordiyenko, Yuliya, Santhanam, Balaji, Wolf, Jana, Wiederhold, Katrin, Dornan, Gillian L., Skehel, Mark, Robinson, Carol V., Passmore, Lori A.
Publicado 2017

Structure of the Fanconi anemia monoubiquitin ligase complex

por Shakeel, Shabih, Rajendra, Eeson, Alcón, Pablo, O’Reilly, Francis, Chorev, Dror S., Maslen, Sarah, Degliesposti, Gianluca, Russo, Christopher J., He, Shaoda, Hill, Chris H., Skehel, J. Mark, Scheres, Sjors H.W., Patel, Ketan J., Rappsilber, Juri, Robinson, Carol V., Passmore, Lori A.
Publicado 2019

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study

por Iacobucci, Claudio, Piotrowski, Christine, Aebersold, Ruedi, Amaral, Bruno C., Andrews, Philip, Bernfur, Katja, Borchers, Christoph, Brodie, Nicolas I., Bruce, James E., Cao, Yong, Chaignepain, Stéphane, Chavez, Juan D., Claverol, Stéphane, Cox, Jürgen, Davis, Trisha, Degliesposti, Gianluca, Dong, Meng-Qiu, Edinger, Nufar, Emanuelsson, Cecilia, Gay, Marina, Götze, Michael, Gomes-Neto, Francisco, Gozzo, Fabio C., Gutierrez, Craig, Haupt, Caroline, Heck, Albert J. R., Herzog, Franz, Huang, Lan, Hoopmann, Michael R., Kalisman, Nir, Klykov, Oleg, Kukačka, Zdeněk, Liu, Fan, MacCoss, Michael J., Mechtler, Karl, Mesika, Ravit, Moritz, Robert L., Nagaraj, Nagarjuna, Nesati, Victor, Neves-Ferreira, Ana G. C., Ninnis, Robert, Novák, Petr, O’Reilly, Francis J., Pelzing, Matthias, Petrotchenko, Evgeniy, Piersimoni, Lolita, Plasencia, Manolo, Pukala, Tara, Rand, Kasper D., Rappsilber, Juri, Reichmann, Dana, Sailer, Carolin, Sarnowski, Chris P., Scheltema, Richard A., Schmidt, Carla, Schriemer, David C., Shi, Yi, Skehel, J. Mark, Slavin, Moriya, Sobott, Frank, Solis-Mezarino, Victor, Stephanowitz, Heike, Stengel, Florian, Stieger, Christian E., Trabjerg, Esben, Trnka, Michael, Vilaseca, Marta, Viner, Rosa, Xiang, Yufei, Yilmaz, Sule, Zelter, Alex, Ziemianowicz, Daniel, Leitner, Alexander, Sinz, Andrea
Publicado 2019