Genome Editing for CNS Disorders

por Duarte, Fábio, Déglon, Nicole
Publicado 2020

Corrigendum: Genome Editing for CNS Disorders

por Duarte, Fábio, Déglon, Nicole
Publicado 2021

Efficient gene delivery and selective transduction of astrocytes in the mammalian brain using viral vectors

por Merienne, Nicolas, Douce, Juliette Le, Faivre, Emilie, Déglon, Nicole, Bonvento, Gilles
Publicado 2013

Development of Efficient AAV2/DJ-Based Viral Vectors to Selectively Downregulate the Expression of Neuronal or Astrocytic Target Proteins in the Rat Central Nervous System

por Jollé, Charlotte, Déglon, Nicole, Pythoud, Catherine, Bouzier-Sore, Anne-Karine, Pellerin, Luc
Publicado 2019

Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level

por Udry, Florian, Decembrini, Sarah, Gamm, David M., Déglon, Nicole, Kostic, Corinne, Arsenijevic, Yvan
Publicado 2020

RNA Interference Mitigates Motor and Neuropathological Deficits in a Cerebellar Mouse Model of Machado-Joseph Disease

por Nóbrega, Clévio, Nascimento-Ferreira, Isabel, Onofre, Isabel, Albuquerque, David, Déglon, Nicole, Pereira de Almeida, Luís
Publicado 2014

Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter

por Martin, Elodie, Betuing, Sandrine, Pagès, Christiane, Cambon, Karine, Auregan, Gwenaelle, Deglon, Nicole, Roze, Emmanuel, Caboche, Jocelyne
Publicado 2011

Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice

por Nóbrega, Clévio, Nascimento-Ferreira, Isabel, Onofre, Isabel, Albuquerque, David, Hirai, Hirokazu, Déglon, Nicole, de Almeida, Luís Pereira
Publicado 2013

Normal Aging Modulates the Neurotoxicity of Mutant Huntingtin

por Diguet, Elsa, Petit, Fanny, Escartin, Carole, Cambon, Karine, Bizat, Nicolas, Dufour, Noëlle, Hantraye, Philippe, Déglon, Nicole, Brouillet, Emmanuel
Publicado 2009

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

por Blessing, Daniel, Vachey, Gabriel, Pythoud, Catherine, Rey, Maria, Padrun, Vivianne, Wurm, Florian M., Schneider, Bernard L., Déglon, Nicole
Publicado 2018

Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells

por Lopes, Carla, Aubert, Sophie, Bourgois-Rocha, Fany, Barnat, Monia, Rego, Ana Cristina, Déglon, Nicole, Perrier, Anselme L., Humbert, Sandrine
Publicado 2016

A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation

por Mazuel, Leslie, Blanc, Jordy, Repond, Cendrine, Bouchaud, Véronique, Raffard, Gérard, Déglon, Nicole, Bonvento, Gilles, Pellerin, Luc, Bouzier-Sore, Anne-Karine
Publicado 2017

Maximizing lentiviral vector gene transfer in the CNS

por Humbel, Morgane, Ramosaj, Mergim, Zimmer, Virginie, Regio, Sara, Aeby, Ludiwine, Moser, Sylvain, Boizot, Alexia, Sipion, Mélanie, Rey, Maria, Déglon, Nicole
Publicado 2020

Correction: Maximizing lentiviral vector gene transfer in the CNS

por Humbel, Morgane, Ramosaj, Mergim, Zimmer, Virginie, Regio, Sara, Aeby, Ludiwine, Moser, Sylvain, Boizot, Alexia, Sipion, Mélanie, Rey, Maria, Déglon, Nicole
Publicado 2022

Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease

por Novati, Arianna, Hentrich, Thomas, Wassouf, Zinah, Weber, Jonasz J., Yu-Taeger, Libo, Déglon, Nicole, Nguyen, Huu Phuc, Schulze-Hentrich, Julia M.
Publicado 2018

AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease

por Vázquez-Manrique, Rafael P., Farina, Francesca, Cambon, Karine, Dolores Sequedo, María, Parker, Alex J., Millán, José María, Weiss, Andreas, Déglon, Nicole, Neri, Christian
Publicado 2016

A New Tool for In Vivo Study of Astrocyte Connexin 43 in Brain

por Droguerre, Marine, Tsurugizawa, Tomokazu, Duchêne, Adeline, Portal, Benjamin, Guiard, Bruno P., Déglon, Nicole, Rouach, Nathalie, Hamon, Michel, Mouthon, Franck, Ciobanu, Luisa, Charvériat, Mathieu
Publicado 2019

Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II

por Benchoua, Alexandra, Trioulier, Yaël, Diguet, Elsa, Malgorn, Carole, Gaillard, Marie-Claude, Dufour, Noelle, Elalouf, Jean-Marc, Krajewski, Stan, Hantraye, Philippe, Déglon, Nicole, Brouillet, Emmanuel
Publicado 2008

Efficacy of THN201, a Combination of Donepezil and Mefloquine, to Reverse Neurocognitive Deficits in Alzheimer’s Disease

por Droguerre, Marine, Duchêne, Adeline, Picoli, Christèle, Portal, Benjamin, Lejards, Camille, Guiard, Bruno P., Meunier, Johann, Villard, Vanessa, Déglon, Nicole, Hamon, Michel, Mouthon, Franck, Charvériat, Mathieu
Publicado 2020

Allele-Specific RNA Silencing of Mutant Ataxin-3 Mediates Neuroprotection in a Rat Model of Machado-Joseph Disease

por Alves, Sandro, Nascimento-Ferreira, Isabel, Auregan, Gwennaëlle, Hassig, Raymonde, Dufour, Noëlle, Brouillet, Emmanuel, Pedroso de Lima, Maria C., Hantraye, Philippe, Pereira de Almeida, Luís, Déglon, Nicole
Publicado 2008