Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval

por King, Emily A., Davis, J. Wade, Degner, Jacob F.
Publicado 2019

Estimating colocalization probability from limited summary statistics

por King, Emily A., Dunbar, Fengjiao, Davis, Justin Wade, Degner, Jacob F.
Publicado 2021

Population Pharmacokinetics of Elagolix in Combination with Low-Dose Estradiol/Norethindrone Acetate in Women with Uterine Fibroids

por Beck, Denise, Winzenborg, Insa, Liu, Mohan, Degner, Jacob, Mostafa, Nael M., Noertersheuser, Peter, Shebley, Mohamad
Publicado 2021

Identification of HLA-DRB1 association to adalimumab immunogenicity

por Liu, Mohan, Degner, Jacob, Davis, Justin Wade, Idler, Kenneth B., Nader, Ahmed, Mostafa, Nael M., Waring, Jeffrey F.
Publicado 2018

Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data

por Degner, Jacob F., Marioni, John C., Pai, Athma A., Pickrell, Joseph K., Nkadori, Everlyne, Gilad, Yoav, Pritchard, Jonathan K.
Publicado 2009

DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

por Bell, Jordana T, Pai, Athma A, Pickrell, Joseph K, Gaffney, Daniel J, Pique-Regi, Roger, Degner, Jacob F, Gilad, Yoav, Pritchard, Jonathan K
Publicado 2011

Correction: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

por Bell, Jordana T, Pai, Athma A, Pickrell, Joseph K, Gaffney, Daniel J, Pique-Regi, Roger, Degner, Jacob F, Gilad, Yoav, Pritchard, Jonathan K
Publicado 2011

Dissecting the regulatory architecture of gene expression QTLs

por Gaffney, Daniel J, Veyrieras, Jean-Baptiste, Degner, Jacob F, Pique-Regi, Roger, Pai, Athma A, Crawford, Gregory E, Stephens, Matthew, Gilad, Yoav, Pritchard, Jonathan K
Publicado 2012

Methylation QTLs Are Associated with Coordinated Changes in Transcription Factor Binding, Histone Modifications, and Gene Expression Levels

por Banovich, Nicholas E., Lan, Xun, McVicker, Graham, van de Geijn, Bryce, Degner, Jacob F., Blischak, John D., Roux, Julien, Pritchard, Jonathan K., Gilad, Yoav
Publicado 2014

The Contribution of RNA Decay Quantitative Trait Loci to Inter-Individual Variation in Steady-State Gene Expression Levels

por Pai, Athma A., Cain, Carolyn E., Mizrahi-Man, Orna, De Leon, Sherryl, Lewellen, Noah, Veyrieras, Jean-Baptiste, Degner, Jacob F., Gaffney, Daniel J., Pickrell, Joseph K., Stephens, Matthew, Pritchard, Jonathan K., Gilad, Yoav
Publicado 2012

DNaseI sensitivity QTLs are a major determinant of human expression variation

por Degner, Jacob F., Pai, Athma A., Pique-Regi, Roger, Veyrieras, Jean-Baptiste, Gaffney, Daniel J., Pickrell, Joseph K., De Leon, Sherryl, Michelini, Katelyn, Lewellen, Noah, Crawford, Gregory E., Stephens, Matthew, Gilad, Yoav, Pritchard, Jonathan K.
Publicado 2012