Targeting RIPK1,2,3 to combat inflammation

por Bullock, Alex N., Degterev, Alexei
Publicado 2015

The channel of death

por Degterev, Alexei, Boyce, Michael, Yuan, Junying
Publicado 2001

Targeting RIPK1 for the treatment of human diseases

por Degterev, Alexei, Ofengeim, Dimitry, Yuan, Junying
Publicado 2019

A genome-wide RNAi screen reveals multiple regulators of caspase activation

por Yi, Caroline H., Sogah, Dodzie K., Boyce, Michael, Degterev, Alexei, Christofferson, Dana E., Yuan, Junying
Publicado 2007

ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

por Muendlein, Hayley I., Connolly, Wilson M., Magri, Zoie, Smirnova, Irina, Ilyukha, Vladimir, Gautam, Avishekh, Degterev, Alexei, Poltorak, Alexander
Publicado 2021

ZBP1 promotes inflammatory responses downstream of TLR3/TLR4 via timely delivery of RIPK1 to TRIF

por Muendlein, Hayley I., Connolly, Wilson M., Magri, Zoie, Jetton, David, Smirnova, Irina, Degterev, Alexei, Balachandran, Siddharth, Poltorak, Alexander
Publicado 2022

Inhibition of cell migration by PITENINs: the role of ARF6

por Miao, Benchun, Skidan, Igor, Yang, Jinsheng, You, Zerong, Fu, Xueyan, Famulok, Michael, Schaffhausen, Brian, Torchilin, Vladimir, Yuan, Junying, Degterev, Alexei
Publicado 2011

Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors

por Suebsuwong, Chalada, Pinkas, Daniel M., Ray, Soumya S., Bufton, Joshua C., Dai, Bing, Bullock, Alex N., Degterev, Alexei, Cuny, Gregory D.
Publicado 2018

Akt Regulates TNFα Synthesis Downstream of RIP1 Kinase Activation during Necroptosis

por McNamara, Colleen R., Ahuja, Ruchita, Osafo-Addo, Awo D., Barrows, Douglas, Kettenbach, Arminja, Skidan, Igor, Teng, Xin, Cuny, Gregory D., Gerber, Scott, Degterev, Alexei
Publicado 2013

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor

por Delanghe, Tom, Huyghe, Jon, Lee, Seungheon, Priem, Dario, Van Coillie, Samya, Gilbert, Barbara, Choi, Sze Men, Vandenabeele, Peter, Degterev, Alexei, Cuny, Gregory D., Dondelinger, Yves, Bertrand, Mathieu J. M.
Publicado 2021

Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation

por Muendlein, Hayley I., Sarhan, Joseph, Liu, Beiyun C., Connolly, Wilson M., Schworer, Stephen A., Smirnova, Irina, Tang, Amy Y., Ilyukha, Vladimir, Pietruska, Jodie, Tahmasebi, Soroush, Sonenberg, Nahum, Degterev, Alexei, Poltorak, Alexander
Publicado 2020

Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors

por Canning, Peter, Ruan, Qui, Schwerd, Tobias, Hrdinka, Matous, Maki, Jenny L., Saleh, Danish, Suebsuwong, Chalada, Ray, Soumya, Brennan, Paul E., Cuny, Gregory D., Uhlig, Holm H., Gyrd-Hansen, Mads, Degterev, Alexei, Bullock, Alex N.
Publicado 2015

RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis

por Zelic, Matija, Pontarelli, Fabrizio, Woodworth, Lisa, Zhu, Cheng, Mahan, Amy, Ren, Yi, LaMorte, Michael, Gruber, Ross, Keane, Aislinn, Loring, Pequita, Guo, Lilu, Xia, Tai-he, Zhang, Boyao, Orning, Pontus, Lien, Egil, Degterev, Alexei, Hammond, Timothy, Ofengeim, Dimitry
Publicado 2021

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling

por Hrdinka, Matous, Schlicher, Lisa, Dai, Bing, Pinkas, Daniel M, Bufton, Joshua C, Picaud, Sarah, Ward, Jennifer A, Rogers, Catherine, Suebsuwong, Chalada, Nikhar, Sameer, Cuny, Gregory D, Huber, Kilian VM, Filippakopoulos, Panagis, Bullock, Alex N, Degterev, Alexei, Gyrd‐Hansen, Mads
Publicado 2018

Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis

por Wu, Limin, Chung, Joon Yong, Cao, Tian, Jin, Gina, Edmiston, William J., Hickman, Suzanne, Levy, Emily S., Whalen, Jordyn A., Abrams, Eliza Sophie LaRovere, Degterev, Alexei, Lo, Eng H., Tozzi, Lorenzo, Kaplan, David L., El Khoury, Joseph, Whalen, Michael J.
Publicado 2021

Phenytoin inhibits necroptosis

por von Mässenhausen, Anne, Tonnus, Wulf, Himmerkus, Nina, Parmentier, Simon, Saleh, Danish, Rodriguez, Diego, Ousingsawat, Jiraporn, Ang, Rosalind L., Weinberg, Joel M., Sanz, Ana B., Ortiz, Alberto, Zierleyn, Adrian, Becker, Jan Ulrich, Baratte, Blandine, Desban, Nathalie, Bach, Stéphane, Schiessl, Ina Maria, Nogusa, Shoko, Balachandran, Siddharth, Anders, Hans Joachim, Ting, Adrian T., Bleich, Markus, Degterev, Alexei, Kunzelmann, Karl, Bornstein, Stefan R., Green, Douglas R., Hugo, Christian, Linkermann, Andreas
Publicado 2018

Correction to: Phenytoin inhibits necroptosis

por von Mässenhausen, Anne, Tonnus, Wulf, Himmerkus, Nina, Parmentier, Simon, Saleh, Danish, Rodriguez, Diego, Ousingsawat, Jiraporn, Ang, Rosalind L., Weinberg, Joel M., Sanz, Ana B., Ortiz, Alberto, Zierleyn, Adrian, Becker, Jan Ulrich, Baratte, Blandine, Desban, Nathalie, Bach, Stéphane, Schiessl, Ina Maria, Nogusa, Shoko, Balachandran, Siddharth, Anders, Hans Joachim, Ting, Adrian T., Bleich, Markus, Degterev, Alexei, Kunzelmann, Karl, Bornstein, Stefan R., Green, Douglas R., Hugo, Christian, Linkermann, Andreas
Publicado 2018

An atlas of substrate specificities for the human serine/threonine kinome

por Johnson, Jared L., Yaron, Tomer M., Huntsman, Emily M., Kerelsky, Alexander, Song, Junho, Regev, Amit, Lin, Ting-Yu, Liberatore, Katarina, Cizin, Daniel M., Cohen, Benjamin M., Vasan, Neil, Ma, Yilun, Krismer, Konstantin, Robles, Jaylissa Torres, van de Kooij, Bert, van Vlimmeren, Anne E., Andrée-Busch, Nicole, Käufer, Norbert F., Dorovkov, Maxim V., Ryazanov, Alexey G., Takagi, Yuichiro, Kastenhuber, Edward R., Goncalves, Marcus D., Hopkins, Benjamin D., Elemento, Olivier, Taatjes, Dylan J., Maucuer, Alexandre, Yamashita, Akio, Degterev, Alexei, Uduman, Mohamed, Lu, Jingyi, Landry, Sean D., Zhang, Bin, Cossentino, Ian, Linding, Rune, Blenis, John, Hornbeck, Peter V., Turk, Benjamin E., Yaffe, Michael B., Cantley, Lewis C.
Publicado 2023

Apoptotic cell death in disease—Current understanding of the NCCD 2023

por Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco E., Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K. -M., Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravichandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe S., Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strapazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, Gyorgy, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, Alexei, Villunger, Andreas, von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Huang-Tian, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibing, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, Galluzzi, Lorenzo
Publicado 2023