Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis

por Becker, Sidney, Schneider, Christina, Okamura, Hidenori, Crisp, Antony, Amatov, Tynchtyk, Dejmek, Milan, Carell, Thomas
Publicado 2018

Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses

por Konkolova, Eva, Dejmek, Milan, Hřebabecký, Hubert, Šála, Michal, Böserle, Jiří, Nencka, Radim, Boura, Evzen
Publicado 2020

Synthesis and anti-human immunodeficiency virus activity of substituted (o,o-difluorophenyl)-linked-pyrimidines as potent non‐nucleoside reverse transcriptase inhibitors

por Čechová, Lucie, Dejmek, Milan, Baszczyňski, Ondřej, Šaman, David, Gao, Liping, Hu, Eric, Stepan, George, Jansa, Petr, Janeba, Zlatko, Šimon, Petr
Publicado 2019

Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication

por Dejmek, Milan, Konkoľová, Eva, Eyer, Luděk, Straková, Petra, Svoboda, Pavel, Šála, Michal, Krejčová, Kateřina, Růžek, Daniel, Boura, Evzen, Nencka, Radim
Publicado 2021

Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein

por Smola, Miroslav, Gutten, Ondrej, Dejmek, Milan, Kožíšek, Milan, Evangelidis, Thomas, Tehrani, Zahra Aliakbar, Novotná, Barbora, Nencka, Radim, Birkuš, Gabriel, Rulíšek, Lubomír, Boura, Evzen
Publicado 2021

Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists

por Vavřina, Zdeněk, Perlíková, Pavla, Milisavljević, Nemanja, Chevrier, Florian, Smola, Miroslav, Smith, Joshua, Dejmek, Milan, Havlíček, Vojtěch, Buděšínský, Miloš, Liboska, Radek, Vaneková, Lenka, Brynda, Jiří, Boura, Evzen, Řezáčová, Pavlína, Hocek, Michal, Birkuš, Gabriel
Publicado 2022

Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors

por Štefek, Milan, Chalupská, Dominika, Chalupský, Karel, Zgarbová, Michala, Dvořáková, Alexandra, Krafčíková, Petra, Li, Alice Shi Ming, Šála, Michal, Dejmek, Milan, Otava, Tomáš, Chaloupecká, Ema, Kozák, Jaroslav, Kozic, Ján, Vedadi, Masoud, Weber, Jan, Mertlíková-Kaiserová, Helena, Nencka, Radim
Publicado 2023

SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia

por Chambers, Courtney, Cermakova, Katerina, Chan, Yuen San, Kurtz, Kristen, Wohlan, Katharina, Lewis, Andrew Henry, Wang, Christiana, Pham, Anh, Dejmek, Milan, Sala, Michal, Loeza Cabrera, Mario, Aguilar, Rogelio, Nencka, Radim, Lacorazza, H. Daniel, Rau, Rachel E., Hodges, H. Courtney
Publicado 2023

Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping

por Břehová, Petra, Řezníčková, Eva, Škach, Kryštof, Jorda, Radek, Dejmek, Milan, Vojáčková, Veronika, Šála, Michal, Kovalová, Markéta, Dračínský, Martin, Dolníková, Alexandra, Strmeň, Timotej, Kinnertová, Monika, Chalupský, Karel, Dvořáková, Alexandra, Gucký, Tomáš, Mertlíková Kaiserová, Helena, Klener, Pavel, Nencka, Radim, Kryštof, Vladimír
Publicado 2023