Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked

por Wisastra, Rosalina, Dekker, Frank J.
Publicado 2014

Histone acetyltransferases: challenges in targeting bi-substrate enzymes

por Wapenaar, Hannah, Dekker, Frank J.
Publicado 2016

Novel Design Strategies to Enhance the Efficiency of Proteolysis Targeting Chimeras

por Zhao, Chunlong, Dekker, Frank J.
Publicado 2022

The Process and Strategy for Developing Selective Histone Deacetylase 3 Inhibitors

por Cao, Fangyuan, Zwinderman, Martijn R. H., Dekker, Frank J.
Publicado 2018

Targeting HDAC Complexes in Asthma and COPD

por Zwinderman, Martijn R. H., de Weerd, Sander, Dekker, Frank J.
Publicado 2019

Improving TRAIL-induced apoptosis in cancers by interfering with histone modifications

por Zhang, Bao-Jie, Chen, Deng, Dekker, Frank J., Quax, Wim J.
Publicado 2020

Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury

por Song, Shanshan, Xiao, Zhangping, Dekker, Frank J., Poelarends, Gerrit J., Melgert, Barbro N.
Publicado 2022

Replacement of an Indole Scaffold Targeting Human 15‐Lipoxygenase‐1 Using Combinatorial Chemistry

por Prismawan, Deka, van der Vlag, Ramon, Guo, Hao, Dekker, Frank J., Hirsch, Anna K. H.
Publicado 2019

A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices

por Prins, Grietje H., Luangmonkong, Theerut, Oosterhuis, Dorenda, Mutsaers, Henricus A. M., Dekker, Frank J., Olinga, Peter
Publicado 2019

Identification of a Bromodomain‐like Region in 15‐Lipoxygenase‐1 Explains Its Nuclear Localization

por Chen, Deng, Xiao, Zhangping, Guo, Hao, Gogishvili, Dea, Setroikromo, Rita, van der Wouden, Petra E., Dekker, Frank J.
Publicado 2021

Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans

por Raj, Hans, Puthan Veetil, Vinod, Szymanski, Wiktor, Dekker, Frank J., Quax, Wim J., Feringa, Ben L., Janssen, Dick B., Poelarends, Gerrit J.
Publicado 2011

Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing

por Liu, Bin, Chen, Siwei, Rose, Anouk La, Chen, Deng, Cao, Fangyuan, Zwinderman, Martijn, Kiemel, Dominik, Aïssi, Manon, Dekker, Frank J, Haisma, Hidde J
Publicado 2020

Adsorptive Microtiter Plates As Solid Supports in Affinity Purification Workflows

por Klont, Frank, Kwiatkowski, Marcel, Faiz, Alen, van den Bosch, Thea, Pouwels, Simon D., Dekker, Frank J., ten Hacken, Nick H.T., Horvatovich, Péter, Bischoff, Rainer
Publicado 2021

4‐Iodopyrimidine Labeling Reveals Nuclear Translocation and Nuclease Activity for Both MIF and MIF2

por Xiao, Zhangping, Chen, Deng, Mulder, Fabian, Song, Shanshan, van der Wouden, Petra E., Cool, Robbert H., Melgert, Barbro N., Poelarends, Gerrit J., Dekker, Frank J.
Publicado 2021

Aqueous Oxidative Heck Reaction as a Protein-Labeling Strategy

por Ourailidou, Maria Eleni, van der Meer, Jan-Ytzen, Baas, Bert-Jan, Jeronimus-Stratingh, Margot, Gottumukkala, Aditya L, Poelarends, Gerrit J, Minnaard, Adriaan J, Dekker, Frank J
Publicado 2014

Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti‐Proliferative Activity in Lung Cancer Cells

por Xiao, Zhangping, Song, Shanshan, Chen, Deng, van Merkerk, Ronald, van der Wouden, Petra E., Cool, Robbert H., Quax, Wim J., Poelarends, Gerrit J., Melgert, Barbro N., Dekker, Frank J.
Publicado 2021

Deposition Bias of Chromatin Proteins Inverts under DNA Replication Stress Conditions

por Zwinderman, Martijn R. H., Lobo, Thamar Jessurun, van der Wouden, Petra E., Spierings, Diana C. J., van Vugt, Marcel A. T. M., Lansdorp, Peter M., Guryev, Victor, Dekker, Frank J.
Publicado 2021

Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos

por Chen, Deng, Osipyan, Angelina, Adriana, Jeaunice, Kader, Mohammed, Gureev, Maxim, Knol, Catharina W. J., Sigmund, Marie-Cathérine, Xiao, Zhangping, van der Wouden, Petra E., Cool, Robbert H., Poelarends, Gerrit J., Dekker, Frank J.
Publicado 2023

Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity

por Guo, Hao, Verhoek, Iris C., Prins, Gerian G. H., van der Vlag, Ramon, van der Wouden, Petra E., van Merkerk, Ronald, Quax, Wim J., Olinga, Peter, Hirsch, Anna K. H., Dekker, Frank J.
Publicado 2019

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional a...

por Leus, Niek G.J., van der Wouden, Petra E., van den Bosch, Thea, Hooghiemstra, Wouter T.R., Ourailidou, Maria E., Kistemaker, Loes E.M., Bischoff, Rainer, Gosens, Reinoud, Haisma, Hidde J., Dekker, Frank J.
Publicado 2016