Canagliflozin mediated dual inhibition of mitochondrial glutamate dehydrogenase and complex I: an off-target adverse effect

por Secker, Philipp F., Beneke, Sascha, Schlichenmaier, Nadja, Delp, Johannes, Gutbier, Simon, Leist, Marcel, Dietrich, Daniel R.
Publicado 2018

Pharmacological LRH-1/Nr5a2 inhibition limits pro-inflammatory cytokine production in macrophages and associated experimental hepatitis

por Schwaderer, Juliane, Phan, Truong San, Glöckner, Astrid, Delp, Johannes, Leist, Marcel, Brunner, Thomas, Delgado, M. Eugenia
Publicado 2020

Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E.coli

por Gerding, Hanne R., Karreman, Christiaan, Daiber, Andreas, Delp, Johannes, Hammler, Daniel, Mex, Martin, Schildknecht, Stefan, Leist, Marcel
Publicado 2019

Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress

por Gutbier, Simon, Spreng, Anna-Sophie, Delp, Johannes, Schildknecht, Stefan, Karreman, Christiaan, Suciu, Ilinca, Brunner, Thomas, Groettrup, Marcus, Leist, Marcel
Publicado 2018

Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift

por Gutbier, Simon, May, Patrick, Berthelot, Sylvie, Krishna, Abhimanyu, Trefzer, Timo, Behbehani, Mehri, Efremova, Liudmila, Delp, Johannes, Gstraunthaler, Gerhard, Waldmann, Tanja, Leist, Marcel
Publicado 2018

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

por Suciu, Ilinca, Delp, Johannes, Gutbier, Simon, Ückert, Anna-Katharina, Spreng, Anna-Sophie, Eberhard, Philipp, Karreman, Christiaan, Schreiber, Falk, Madjar, Katrin, Rahnenführer, Jörg, Celardo, Ivana, Amelio, Ivano, Leist, Marcel
Publicado 2023

A High-Throughput Approach to Identify Specific Neurotoxicants / Developmental Toxicants in Human Neuronal Cell Function Assays

por Delp, Johannes, Gutbier, Simon, Klima, Stefanie, Hoelting, Lisa, Pinto-Gil, Kevin, Hsieh, Jui-Hua, Aichem, Michael, Klein, Karsten, Schreiber, Falk, Tice, Raymond R., Pastor, Manuel, Behl, Mamta, Leist, Marcel
Publicado 2018

Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells

por Carta, Giada, van der Stel, Wanda, Scuric, Emma W. J., Capinha, Liliana, Delp, Johannes, Bennekou, Susanne Hougaard, Forsby, Anna, Walker, Paul, Leist, Marcel, van de Water, Bob, Jennings, Paul
Publicado 2023

Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals

por van der Stel, Wanda, Carta, Giada, Eakins, Julie, Darici, Salihanur, Delp, Johannes, Forsby, Anna, Bennekou, Susanne Hougaard, Gardner, Iain, Leist, Marcel, Danen, Erik H. J., Walker, Paul, van de Water, Bob, Jennings, Paul
Publicado 2020

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors

por Delp, Johannes, Cediel-Ulloa, Andrea, Suciu, Ilinca, Kranaster, Petra, van Vugt-Lussenburg, Barbara MA, Munic Kos, Vesna, van der Stel, Wanda, Carta, Giada, Bennekou, Susanne Hougaard, Jennings, Paul, van de Water, Bob, Forsby, Anna, Leist, Marcel
Publicado 2021

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

por van der Stel, Wanda, Yang, Huan, Vrijenhoek, Nanette G., Schimming, Johannes P., Callegaro, Giulia, Carta, Giada, Darici, Salihanur, Delp, Johannes, Forsby, Anna, White, Andrew, le Dévédec, Sylvia, Leist, Marcel, Jennings, Paul, Beltman, Joost B., van de Water, Bob, Danen, Erik H. J.
Publicado 2021