Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases

por Hausdorff, Marcel, Delpal, Adrien, Barelier, Sarah, Nicollet, Laura, Canard, Bruno, Touret, Franck, Colmant, Agathe, Coutard, Bruno, Vasseur, Jean-Jacques, Decroly, Etienne, Debart, Françoise
Publicado 2023

A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro

por De Castro, Sonia, Stevaert, Annelies, Maldonado, Miguel, Delpal, Adrien, Vandeput, Julie, Van Loy, Benjamin, Eydoux, Cecilia, Guillemot, Jean-Claude, Decroly, Etienne, Gago, Federico, Canard, Bruno, Camarasa, Maria-Jose, Velázquez, Sonsoles, Naesens, Lieve
Publicado 2022

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

por Essalmani, Rachid, Jain, Jaspreet, Susan-Resiga, Delia, Andréo, Ursula, Evagelidis, Alexandra, Derbali, Rabeb Mouna, Huynh, David N., Dallaire, Frédéric, Laporte, Mélanie, Delpal, Adrien, Sutto-Ortiz, Priscila, Coutard, Bruno, Mapa, Claudine, Wilcoxen, Keith, Decroly, Etienne, NQ Pham, Tram, Cohen, Éric A., Seidah, Nabil G.
Publicado 2022

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

por Shannon, Ashleigh, Fattorini, Véronique, Sama, Bhawna, Selisko, Barbara, Feracci, Mikael, Falcou, Camille, Gauffre, Pierre, El Kazzi, Priscila, Delpal, Adrien, Decroly, Etienne, Alvarez, Karine, Eydoux, Cécilia, Guillemot, Jean-Claude, Moussa, Adel, Good, Steven S., La Colla, Paolo, Lin, Kai, Sommadossi, Jean-Pierre, Zhu, Yingxiao, Yan, Xiaodong, Shi, Hui, Ferron, François, Canard, Bruno
Publicado 2022

Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

por Bardiot, Dorothée, Vangeel, Laura, Koukni, Mohamed, Arzel, Philippe, Zwaagstra, Marleen, Lyoo, Heyrhyoung, Wanningen, Patrick, Ahmad, Shamshad, Zhang, Linlin, Sun, Xinyuanyuan, Delpal, Adrien, Eydoux, Cecilia, Guillemot, Jean-Claude, Lescrinier, Eveline, Klaassen, Hugo, Leyssen, Pieter, Jochmans, Dirk, Castermans, Karolien, Hilgenfeld, Rolf, Robinson, Colin, Decroly, Etienne, Canard, Bruno, Snijder, Eric J., van Hemert, Martijn J., van Kuppeveld, Frank, Chaltin, Patrick, Neyts, Johan, De Jonghe, Steven, Marchand, Arnaud
Publicado 2022