Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras

por Vranckx, Lenard S., Demeulemeester, Jonas, Debyser, Zeger, Gijsbers, Rik
Publicado 2016

Transcriptional Profiling of STAT1 Gain-of-Function Reveals Common and Mutation-Specific Fingerprints

por Giovannozzi, Simone, Demeulemeester, Jonas, Schrijvers, Rik, Gijsbers, Rik
Publicado 2021

Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection

por Demeulemeester, Jonas, De Rijck, Jan, Gijsbers, Rik, Debyser, Zeger
Publicado 2015

Biallelic mutations in cancer genomes reveal local mutational determinants

por Demeulemeester, Jonas, Dentro, Stefan C., Gerstung, Moritz, Van Loo, Peter
Publicado 2022

Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug Discovery

por Taltynov, Oliver, Desimmie, Belete A., Demeulemeester, Jonas, Christ, Frauke, Debyser, Zeger
Publicado 2012

A pan-cancer landscape of somatic mutations in non-unique regions of the human genome

por Tarabichi, Maxime, Demeulemeester, Jonas, Verfaillie, Annelien, Flanagan, Adrienne M., Van Loo, Peter, Konopka, Tomasz
Publicado 2021

A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication

por Serrao, Erik, Thys, Wannes, Demeulemeester, Jonas, Al-Mawsawi, Laith Q., Christ, Frauke, Debyser, Zeger, Neamati, Nouri
Publicado 2012

HIV Virions as Nanoscopic Test Tubes for Probing Oligomerization of the Integrase Enzyme

por Borrenberghs, Doortje, Thys, Wannes, Rocha, Susana, Demeulemeester, Jonas, Weydert, Caroline, Dedecker, Peter, Hofkens, Johan, Debyser, Zeger, Hendrix, Jelle
Publicado 2014

BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements

por El Ashkar, Sara, De Rijck, Jan, Demeulemeester, Jonas, Vets, Sofie, Madlala, Paradise, Cermakova, Katerina, Debyser, Zeger, Gijsbers, Rik
Publicado 2014

Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import

por Demeulemeester, Jonas, Blokken, Jolien, De Houwer, Stéphanie, Dirix, Lieve, Klaassen, Hugo, Marchand, Arnaud, Chaltin, Patrick, Christ, Frauke, Debyser, Zeger
Publicado 2018

2-Hydroxyisoquinoline-1,3(2H, 4H)diones (HQDs), novel inhibitors of the HIV integrase catalytic activity with a high barrier to resistance

por Christ, Frauke, Demeulemeester, Jonas, Desimmie, Belete, Suchaud, Virginie, Taltynov, Oliver, Lion, Cedric, Bailly, Fabrice, Strelkov, Sergei, Cotelle, Philipe, Debyser, Zeger
Publicado 2013

Analysis of long and short enhancers in melanoma cell states

por Mauduit, David, Taskiran, Ibrahim Ihsan, Minnoye, Liesbeth, de Waegeneer, Maxime, Christiaens, Valerie, Hulselmans, Gert, Demeulemeester, Jonas, Wouters, Jasper, Aerts, Stein
Publicado 2021

Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy

por El Ashkar, Sara, Van Looveren, Dominique, Schenk, Franziska, Vranckx, Lenard S., Demeulemeester, Jonas, De Rijck, Jan, Debyser, Zeger, Modlich, Ute, Gijsbers, Rik
Publicado 2017

Interplay between HIV Entry and Transportin-SR2 Dependency

por Thys, Wannes, De Houwer, Stéphanie, Demeulemeester, Jonas, Taltynov, Oliver, Vancraenenbroeck, Renée, Gérard, Melanie, De Rijck, Jan, Gijsbers, Rik, Christ, Frauke, Debyser, Zeger
Publicado 2011

LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs

por Schrijvers, Rik, De Rijck, Jan, Demeulemeester, Jonas, Adachi, Noritaka, Vets, Sofie, Ronen, Keshet, Christ, Frauke, Bushman, Frederic D., Debyser, Zeger, Gijsbers, Rik
Publicado 2012

Correction: LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs

por Schrijvers, Rik, Rijck, Jan De, Demeulemeester, Jonas, Adachi, Noritaka, Vets, Sofie, Ronen, Keshet, Christ, Frauke, Bushman, Frederic D., Debyser, Zeger, Gijsbers, Rik
Publicado 2020

Bromodomain and extra-terminal (BET) proteins target Moloney murine leukemia virus integration to transcription start sites

por De Riick, Jan, de Kogel, Christine, Demeulemeester, Jonas, Vets, Sofie, Malani, Nirav, Bushman, Frederic D, Busschots, Katrien, Husson, Steven, Gijsbers, Rik, Debyser, Zeger
Publicado 2013

Interpretation of allele-specific chromatin accessibility using cell state–aware deep learning

por Atak, Zeynep Kalender, Taskiran, Ibrahim Ihsan, Demeulemeester, Jonas, Flerin, Christopher, Mauduit, David, Minnoye, Liesbeth, Hulselmans, Gert, Christiaens, Valerie, Ghanem, Ghanem-Elias, Wouters, Jasper, Aerts, Stein
Publicado 2021

LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV

por Vranckx, Lenard S., Demeulemeester, Jonas, Saleh, Suha, Boll, Annegret, Vansant, Gerlinde, Schrijvers, Rik, Weydert, Caroline, Battivelli, Emilie, Verdin, Eric, Cereseto, Anna, Christ, Frauke, Gijsbers, Rik, Debyser, Zeger
Publicado 2016

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles

por Desimmie, Belete Ayele, Weydert, Caroline, Schrijvers, Rik, Vets, Sofie, Demeulemeester, Jonas, Proost, Paul, Paron, Igor, De Rijck, Jan, Mast, Jan, Bannert, Norbert, Gijsbers, Rik, Christ, Frauke, Debyser, Zeger
Publicado 2015