Evaluating the Incidence of Opioid-Induced Respiratory Depression Associated with Oliceridine and Morphine as Measured by the Frequency and Average Cumulative Duration of Dosing In...

por Ayad, Sabry, Demitrack, Mark A., Burt, David A., Michalsky, Cathy, Wase, Linda, Fossler, Michael J., Khanna, Ashish K.
Publicado 2020

APOLLO‐2: A Randomized, Placebo and Active‐Controlled Phase III Study Investigating Oliceridine (TRV130), a G Protein–Biased Ligand at the μ‐Opioid Receptor, for Management of Mode...

por Singla, Neil K., Skobieranda, Franck, Soergel, David G., Salamea, Monica, Burt, David A., Demitrack, Mark A., Viscusi, Eugene R.
Publicado 2019

A Phase I, Randomized, Single‑Blind, Placebo‑Controlled, Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of Subcutaneous and Oral TRV250, a G Protein-...

por Fossler, Michael J., Schmith, Virginia, Greene, Stephen A., Lohmer, Lauren, Kramer, Michael S., Arscott, Kelly, James, Ian E., Demitrack, Mark A.
Publicado 2020

Oliceridine Exhibits Improved Tolerability Compared to Morphine at Equianalgesic Conditions: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Controlled Trials

por Hammer, Gregory B., Khanna, Ashish K., Michalsky, Cathy, Wase, Linda, Demitrack, Mark A., Little, Roderick, Fossler, Michael J., Ayad, Sabry
Publicado 2021

Neurostructural Differences in Adolescents With Treatment-Resistant Depression and Treatment Effects of Transcranial Magnetic Stimulation

por Seewoo, Bhedita J, Rodger, Jennifer, Demitrack, Mark A, Heart, Karen L, Port, John D, Strawn, Jeffrey R, Croarkin, Paul E
Publicado 2022

Low Incidence of Postoperative Respiratory Depression with Oliceridine Compared to Morphine: A Retrospective Chart Analysis

por Bergese, Sergio, Berkowitz, Richard, Rider, Paul, Ladouceur, Martin, Griffith, Suzanne, Segura Vasi, Alvaro, Cochrane, Kristina, Wase, Linda, Demitrack, Mark A., Habib, Ashraf S.
Publicado 2020

Oliceridine is Associated with Reduced Risk of Vomiting and Need for Rescue Antiemetics Compared to Morphine: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Co...

por Beard, Timothy L., Michalsky, Cathy, Candiotti, Keith A., Rider, Paul, Wase, Linda, Habib, Ashraf S., Demitrack, Mark A., Fossler, Michael J., Viscusi, Eugene R.
Publicado 2020

Low Incidence of Opioid-Induced Respiratory Depression Observed with Oliceridine Regardless of Age or Body Mass Index: Exploratory Analysis from a Phase 3 Open-Label Trial in Posts...

por Brzezinski, Marek, Hammer, Gregory B., Candiotti, Keith A., Bergese, Sergio D., Pan, Peter H., Bourne, Michael H., Michalsky, Cathy, Wase, Linda, Demitrack, Mark A., Habib, Ashraf S.
Publicado 2021