Electrophysiological characterization of the modified hERG(T) potassium channel used to obtain the first cryo‐EM hERG structure

por Zhang, Yihong, Dempsey, Christopher E., Hancox, Jules C.
Publicado 2020

The Basis for Low-affinity hERG Potassium Channel Block by Sotalol

por Zhang, Yi Hong, Dempsey, Christopher E., Hancox, Jules C.
Publicado 2017

Thermodynamics of RTA3 peptide binding to membranes and consequences for antimicrobial activity()

por Hawrani, Ayman, Howe, Robin A., Walsh, Timothy R., Dempsey, Christopher E.
Publicado 2010

Analysis of α-Dystroglycan/LG Domain Binding Modes: Investigating Protein Motifs That Regulate the Affinity of Isolated LG Domains

por Dempsey, Christopher E., Bigotti, Maria Giulia, Adams, Josephine C., Brancaccio, Andrea
Publicado 2019

Arginine side chain interactions and the role of arginine as a gating charge carrier in voltage sensitive ion channels

por Armstrong, Craig T., Mason, Philip E., Anderson, J. L. Ross, Dempsey, Christopher E.
Publicado 2016

Identification of a proton sensor that regulates conductance and open time of single hERG channels

por Wilson, Stacey L., Dempsey, Christopher E., Hancox, Jules C., Marrion, Neil V.
Publicado 2019

Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants

por Du, Chunyun, Zhang, Yihong, El Harchi, Aziza, Dempsey, Christopher E., Hancox, Jules C.
Publicado 2014

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

por Melgari, Dario, Zhang, Yihong, El Harchi, Aziza, Dempsey, Christopher E., Hancox, Jules C.
Publicado 2015

Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome

por Butler, Andrew, Zhang, Yihong, Stuart, Alan G., Dempsey, Christopher E., Hancox, Jules C.
Publicado 2018

Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome

por Butler, Andrew, Zhang, Yihong, Stuart, A. Graham, Dempsey, Christopher E., Hancox, Jules C.
Publicado 2019

An Update on the Structure of hERG

por Butler, Andrew, Helliwell, Matthew V., Zhang, Yihong, Hancox, Jules C., Dempsey, Christopher E.
Publicado 2020

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine

por El Harchi, Aziza, Butler, Andrew S., Zhang, Yihong, Dempsey, Christopher E., Hancox, Jules C.
Publicado 2020

Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue

por Helliwell, Matthew V., Zhang, Yihong, El Harchi, Aziza, Dempsey, Christopher E., Hancox, Jules C.
Publicado 2023

Assessing hERG Pore Models As Templates for Drug Docking Using Published Experimental Constraints: The Inactivated State in the Context of Drug Block

por Dempsey, Christopher E., Wright, Dominic, Colenso, Charlotte K., Sessions, Richard B., Hancox, Jules C.
Publicado 2014

Voltage Sensor Gating Charge Transfer in a hERG Potassium Channel Model

por Colenso, Charlotte K., Cao, Yang, Sessions, Richard B., Hancox, Jules C., Dempsey, Christopher E.
Publicado 2014

Evolutionary coupling analysis guides identification of mistrafficking-sensitive variants in cardiac K(+) channels: Validation with hERG

por Zhang, Yihong, Grimwood, Amy L., Hancox, Jules C., Harmer, Stephen C., Dempsey, Christopher E.
Publicado 2022

The hERG K(+) channel S4 domain L532P mutation: Characterization at 37 °C

por Zhang, Yi H., Colenso, Charlotte K., Sessions, Richard B., Dempsey, Christopher E., Hancox, Jules C.
Publicado 2011

Structural implications of hERG K(+) channel block by a high-affinity minimally structured blocker

por Helliwell, Matthew V., Zhang, Yihong, El Harchi, Aziza, Du, Chunyun, Hancox, Jules C., Dempsey, Christopher E.
Publicado 2018

Serine mutation of a conserved threonine in the hERG K(+) channel S6-pore region leads to loss-of-function through trafficking impairment

por Al-Moubarak, Ehab, Zhang, Yihong, Dempsey, Christopher E., Zhang, Henggui, Harmer, Stephen C., Hancox, Jules C.
Publicado 2020

Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome

por Cheng, Hongwei, Du, Chunyun, Zhang, Yihong, James, Andrew F., Dempsey, Christopher E., Abdala, Ana P., Hancox, Jules C.
Publicado 2019