Diverse antimalarials from whole-cell phenotypic screens disrupt malaria parasite ion and volume homeostasis

por Dennis, Adelaide S. M., Rosling, James E. O., Lehane, Adele M., Kirk, Kiaran
Publicado 2018

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens

por Hapuarachchi, Sanduni V., Cobbold, Simon A., Shafik, Sarah H., Dennis, Adelaide S. M., McConville, Malcolm J., Martin, Rowena E., Kirk, Kiaran, Lehane, Adele M.
Publicado 2017

A G358S mutation in the Plasmodium falciparum Na(+) pump PfATP4 confers clinically-relevant resistance to cipargamin

por Qiu, Deyun, Pei, Jinxin V., Rosling, James E. O., Thathy, Vandana, Li, Dongdi, Xue, Yi, Tanner, John D., Penington, Jocelyn Sietsma, Aw, Yi Tong Vincent, Aw, Jessica Yi Han, Xu, Guoyue, Tripathi, Abhai K., Gnadig, Nina F., Yeo, Tomas, Fairhurst, Kate J., Stokes, Barbara H., Murithi, James M., Kümpornsin, Krittikorn, Hasemer, Heath, Dennis, Adelaide S. M., Ridgway, Melanie C., Schmitt, Esther K., Straimer, Judith, Papenfuss, Anthony T., Lee, Marcus C. S., Corry, Ben, Sinnis, Photini, Fidock, David A., van Dooren, Giel G., Kirk, Kiaran, Lehane, Adele M.
Publicado 2022

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

por Williamson, Alice E., Ylioja, Paul M., Robertson, Murray N., Antonova-Koch, Yevgeniya, Avery, Vicky, Baell, Jonathan B., Batchu, Harikrishna, Batra, Sanjay, Burrows, Jeremy N., Bhattacharyya, Soumya, Calderon, Felix, Charman, Susan A., Clark, Julie, Crespo, Benigno, Dean, Matin, Debbert, Stefan L., Delves, Michael, Dennis, Adelaide S. M., Deroose, Frederik, Duffy, Sandra, Fletcher, Sabine, Giaever, Guri, Hallyburton, Irene, Gamo, Francisco-Javier, Gebbia, Marinella, Guy, R. Kiplin, Hungerford, Zoe, Kirk, Kiaran, Lafuente-Monasterio, Maria J., Lee, Anna, Meister, Stephan, Nislow, Corey, Overington, John P., Papadatos, George, Patiny, Luc, Pham, James, Ralph, Stuart A., Ruecker, Andrea, Ryan, Eileen, Southan, Christopher, Srivastava, Kumkum, Swain, Chris, Tarnowski, Matthew J., Thomson, Patrick, Turner, Peter, Wallace, Iain M., Wells, Timothy N. C., White, Karen, White, Laura, Willis, Paul, Winzeler, Elizabeth A., Wittlin, Sergio, Todd, Matthew H.
Publicado 2016