Neurotoxic Astrocytes Directly Converted from Sporadic and Familial ALS Patient Fibroblasts Reveal Signature Diversities and miR-146a Theragnostic Potential in Specific Subtypes

por Gomes, Cátia, Sequeira, Catarina, Likhite, Shibi, Dennys, Cassandra N., Kolb, Stephen J., Shaw, Pamela J., Vaz, Ana R., Kaspar, Brian K., Meyer, Kathrin, Brites, Dora
Publicado 2022

CuATSM effectively ameliorates ALS patient astrocyte‐mediated motor neuron toxicity in human in vitro models of amyotrophic lateral sclerosis

por Dennys, Cassandra N., Roussel, Florence, Rodrigo, Rochelle, Zhang, Xiaojin, Sierra Delgado, Andrea, Hartlaub, Annalisa, Saelim‐Ector, Asya, Ray, Will, Heintzman, Sarah, Fox, Ashley, Kolb, Stephen J., Beckman, Joseph, Franco, Maria Clara, Meyer, Kathrin
Publicado 2022

Peroxynitrite nitration of Tyr 56 in Hsp90 induces PC12 cell death through P2X7R-dependent PTEN activation

por Jandy, Megan, Noor, Asra, Nelson, Pascal, Dennys, Cassandra N., Karabinas, Isabella M., Pestoni, Jeanine C., Singh, Gautam D., Luc, Lam, Devyldere, Rachel, Perdomo, Nathalie, Mitchell, Catherine E., Adams, Levi, Fuse, Marisa A., Mendoza, Francine A., Marean-Reardon, Carrie L., Mehl, Ryan A., Estevez, Alvaro G., Franco, Maria Clara
Publicado 2022

PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD

por Pilotto, Federica, Schmitz, Alexander, Maharjan, Niran, Diab, Rim, Odriozola, Adolfo, Tripathi, Priyanka, Yamoah, Alfred, Scheidegger, Olivier, Oestmann, Angelina, Dennys, Cassandra N., Sinha Ray, Shrestha, Rodrigo, Rochelle, Kolb, Stephen, Aronica, Eleonora, Di Santo, Stefano, Widmer, Hans Rudolf, Charlet-Berguerand, Nicolas, Selvaraj, Bhuvaneish T, Chandran, Siddharthan, Meyer, Kathrin, Zuber, Benoît, Goswami, Anand, Weis, Joachim, Saxena, Smita
Publicado 2022