Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics

por Denzel, Martin S., Lapierre, Louis R., Mack, Hildegard I.D.
Publicado 2018

Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation

por Derisbourg, Maxime J., Wester, Laura E., Baddi, Ruth, Denzel, Martin S.
Publicado 2021

Hexosamine pathway activation improves memory but does not extend lifespan in mice

por Allmeroth, Kira, Hartman, Matías D., Purrio, Martin, Mesaros, Andrea, Denzel, Martin S.
Publicado 2022

Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis

por Ruegenberg, Sabine, Horn, Moritz, Pichlo, Christian, Allmeroth, Kira, Baumann, Ulrich, Denzel, Martin S.
Publicado 2020

Bortezomib resistance mutations in PSMB5 determine response to second-generation proteasome inhibitors in multiple myeloma

por Allmeroth, Kira, Horn, Moritz, Kroef, Virginia, Miethe, Stephan, Müller, Roman-Ulrich, Denzel, Martin S.
Publicado 2020

Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1

por Ruegenberg, Sabine, Mayr, Felix A. M. C., Atanassov, Ilian, Baumann, Ulrich, Denzel, Martin S.
Publicado 2021

Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells

por Horn, Moritz, Kroef, Virginia, Allmeroth, Kira, Schuller, Nicole, Miethe, Stephan, Peifer, Martin, Penninger, Josef M., Elling, Ulrich, Denzel, Martin S.
Publicado 2018

Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response

por Horn, Moritz, Denzel, Sarah I., Srinivasan, Balaji, Allmeroth, Kira, Schiffer, Isabelle, Karthikaisamy, Vignesh, Miethe, Stephan, Breuer, Peter, Antebi, Adam, Denzel, Martin S.
Publicado 2020

GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway

por Kroef, Virginia, Ruegenberg, Sabine, Horn, Moritz, Allmeroth, Kira, Ebert, Lena, Bozkus, Seyma, Miethe, Stephan, Elling, Ulrich, Schermer, Bernhard, Baumann, Ulrich, Denzel, Martin Sebastian
Publicado 2022

miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging

por Schiffer, Isabelle, Gerisch, Birgit, Kawamura, Kazuto, Laboy, Raymond, Hewitt, Jennifer, Denzel, Martin Sebastian, Mori, Marcelo A, Vanapalli, Siva, Shen, Yidong, Symmons, Orsolya, Antebi, Adam
Publicado 2021

Dual inhibition of HSF1 and DYRK2 impedes cancer progression

por Tandon, Vasudha, Moreno, Rita, Allmeroth, Kira, Quinn, Jean, Wiley, Sandra E., Nicely, Lynden G., Denzel, Martin S., Edwards, Joanne, de la Vega, Laureano, Banerjee, Sourav
Publicado 2023

Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage

por Johnsen, Marc, Späth, Martin Richard, Denzel, Martin S., Göbel, Heike, Kubacki, Torsten, Hoyer, Karla Johanna Ruth, Hinze, Yvonne, Benzing, Thomas, Schermer, Bernhard, Antebi, Adam, Burst, Volker, Müller, Roman-Ulrich
Publicado 2016

N1-acetylspermidine is a determinant of hair follicle stem cell fate

por Allmeroth, Kira, Kim, Christine S., Annibal, Andrea, Pouikli, Andromachi, Koester, Janis, Derisbourg, Maxime J., Andrés Chacón-Martínez, Carlos, Latza, Christian, Antebi, Adam, Tessarz, Peter, Wickström, Sara A., Denzel, Martin S.
Publicado 2021

hESC Differentiation toward an Autonomic Neuronal Cell Fate Depends on Distinct Cues from the Co-Patterning Vasculature

por Acevedo, Lisette M., Lindquist, Jeffrey N., Walsh, Breda M., Sia, Peik, Cimadamore, Flavio, Chen, Connie, Denzel, Martin, Pernia, Cameron D., Ranscht, Barbara, Terskikh, Alexey, Snyder, Evan Y., Cheresh, David A.
Publicado 2015

NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants

por Guerrero, Gabriel A, Derisbourg, Maxime J, Mayr, Felix AMC, Wester, Laura E, Giorda, Marco, Dinort, J Eike, Hartman, Matías D, Schilling, Klara, Alonso-De Gennaro, María José, Lu, Ryan J, Benayoun, Bérénice A, Denzel, Martin S
Publicado 2021

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer

por Strong, Randy, Miller, Richard A., Antebi, Adam, Astle, Clinton M., Bogue, Molly, Denzel, Martin S., Fernandez, Elizabeth, Flurkey, Kevin, Hamilton, Karyn L., Lamming, Dudley W., Javors, Martin A., de Magalhães, João Pedro, Martinez, Paul Anthony, McCord, Joe M., Miller, Benjamin F., Müller, Michael, Nelson, James F., Ndukum, Juliet, Rainger, G. Ed., Richardson, Arlan, Sabatini, David M., Salmon, Adam B., Simpkins, James W., Steegenga, Wilma T., Nadon, Nancy L., Harrison, David E.
Publicado 2016