Are SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?

por Ford, Rebecca J., Desjardins, Eric M., Steinberg, Gregory R.
Publicado 2017

Myostatin inhibition therapy for insulin-deficient type 1 diabetes

por Coleman, Samantha K., Rebalka, Irena A., D’Souza, Donna M., Deodhare, Namita, Desjardins, Eric M., Hawke, Thomas J.
Publicado 2016

FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasi...

por Mottillo, Emilio P., Desjardins, Eric M., Fritzen, Andreas M., Zou, Vito Z., Crane, Justin D., Yabut, Julian M., Kiens, Bente, Erion, Derek M., Lanba, Adhiraj, Granneman, James G., Talukdar, Saswata, Steinberg, Gregory R.
Publicado 2017

Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance

por Yabut, Julian M., Desjardins, Eric M., Chan, Eric J., Day, Emily A., Leroux, Julie M., Wang, Bo, Crane, Elizabeth D., Wong, Wesley, Morrison, Katherine M., Crane, Justin D., Khan, Waliul I., Steinberg, Gregory R.
Publicado 2020

The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

por Desjardins, Eric M., Smith, Brennan K., Day, Emily A., Ducommun, Serge, Sanders, Matthew J., Nederveen, Joshua P., Ford, Rebecca J., Pinkosky, Stephen L., Townsend, Logan K., Gutgesell, Robert M., Lu, Rachel, Sakamoto, Kei, Steinberg, Gregory R.
Publicado 2022

Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice

por Day, Emily A., Townsend, Logan K., Rehal, Sonia, Batchuluun, Battsetseg, Wang, Dongdong, Morrow, Marisa R., Lu, Rachel, Lundenberg, Lucie, Lu, Jessie H., Desjardins, Eric M., Smith, Tyler K.T., Raphenya, Amogelang R., McArthur, Andrew G., Fullerton, Morgan D., Steinberg, Gregory R.
Publicado 2023

Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice

por Desjardins, Eric M., Wu, Jianhan, Lavoie, Declan C.T., Ahmadi, Elham, Townsend, Logan K., Morrow, Marisa R., Wang, Dongdong, Tsakiridis, Evangelia E., Batchuluun, Battsetseg, Fayyazi, Russta, Kwiecien, Jacek M., Tsakiridis, Theodoros, Lally, James S.V., Paré, Guillaume, Pinkosky, Stephen L., Steinberg, Gregory R.
Publicado 2023

The Pesticide Chlorpyrifos Promotes Obesity by Inhibiting Diet-Induced Thermogenesis

por Wang, Bo, Zhang, Shuman, Llanos, Andrea, Tsakiridis, Evangelia E, Desjardins, Eric M, Yabut, Julian M, Green, Alexander E, Day, Emily A, Smith, Brennan K, Lally, James S V, Raphenya, Amogelang R, Srinivasan, Krishna A, McArthur, Andrew G, Kajimura, Shingo, Patel, Jagdish Suresh, Wade, Michael Gordon, Morrison, Katherine Mary, Holloway, Alison, Steinberg, Gregory R
Publicado 2021

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1-isoforms

por Pinkosky, Stephen L., Scott, John W., Desjardins, Eric M., Smith, Brennan K., Day, Emily A., Ford, Rebecca J., Langendorf, Christopher G., Ling, Naomi X. Y., Nero, Tracy L., Loh, Kim, Galic, Sandra, Hoque, Ashfaqul, Smiles, William J., Ngoei, Kevin R.W., Parker, Michael W., Yan, Yan, Melcher, Karsten, Kemp, Bruce E., Oakhill, Jonathan S., Steinberg, Gregory R.
Publicado 2020

Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

por Rhein, Philipp, Desjardins, Eric M., Rong, Ping, Ahwazi, Danial, Bonhoure, Nicolas, Stolte, Jens, Santos, Matthieu D., Ovens, Ashley J., Ehrlich, Amy M., Sanchez Garcia, José L., Ouyang, Qian, Yabut, Julian M., Kjolby, Mads, Membrez, Mathieu, Jessen, Niels, Oakhill, Jonathan S., Treebak, Jonas T., Maire, Pascal, Scott, John W., Sanders, Matthew J., Descombes, Patrick, Chen, Shuai, Steinberg, Gregory R., Sakamoto, Kei
Publicado 2021

The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue

por Wang, Bo, Tsakiridis, Evangelia E., Zhang, Shuman, Llanos, Andrea, Desjardins, Eric M., Yabut, Julian M., Green, Alexander E., Day, Emily A., Smith, Brennan K., Lally, James S. V., Wu, Jianhan, Raphenya, Amogelang R., Srinivasan, Krishna A., McArthur, Andrew G., Kajimura, Shingo, Patel, Jagdish Suresh, Wade, Michael G., Morrison, Katherine M., Holloway, Alison C., Steinberg, Gregory R.
Publicado 2021

Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota

por Ahmed, Basma A., Ong, Frank J., Barra, Nicole G., Blondin, Denis P., Gunn, Elizabeth, Oreskovich, Stephan M., Szamosi, Jake C., Syed, Saad A., Hutchings, Emily K., Konyer, Norman B., Singh, Nina P., Yabut, Julian M., Desjardins, Eric M., Anhê, Fernando F., Foley, Kevin P., Holloway, Alison C., Noseworthy, Michael D., Haman, Francois, Carpentier, Andre C., Surette, Michael G., Schertzer, Jonathan D., Punthakee, Zubin, Steinberg, Gregory R., Morrison, Katherine M.
Publicado 2021

GDF15 promotes weight loss by enhancing energy expenditure in muscle

por Wang, Dongdong, Townsend, Logan K., DesOrmeaux, Geneviève J., Frangos, Sara M., Batchuluun, Battsetseg, Dumont, Lauralyne, Kuhre, Rune Ehrenreich, Ahmadi, Elham, Hu, Sumei, Rebalka, Irena A., Gautam, Jaya, Jabile, Maria Joy Therese, Pileggi, Chantal A., Rehal, Sonia, Desjardins, Eric M., Tsakiridis, Evangelia E., Lally, James S. V., Juracic, Emma Sara, Tupling, A. Russell, Gerstein, Hertzel C., Paré, Guillaume, Tsakiridis, Theodoros, Harper, Mary-Ellen, Hawke, Thomas J., Speakman, John R., Blondin, Denis P., Holloway, Graham P., Jørgensen, Sebastian Beck, Steinberg, Gregory R.
Publicado 2023

Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy

por Drake, Joshua C., Wilson, Rebecca J., Laker, Rhianna C., Guan, Yuntian, Spaulding, Hannah R., Nichenko, Anna S., Shen, Wenqing, Shang, Huayu, Dorn, Maya V., Huang, Kian, Zhang, Mei, Bandara, Aloka B., Brisendine, Matthew H., Kashatus, Jennifer A., Sharma, Poonam R., Young, Alexander, Gautam, Jitendra, Cao, Ruofan, Wallrabe, Horst, Chang, Paul A., Wong, Michael, Desjardins, Eric M., Hawley, Simon A., Christ, George J., Kashatus, David F., Miller, Clint L., Wolf, Matthew J., Periasamy, Ammasi, Steinberg, Gregory R., Hardie, D. Grahame, Yan, Zhen
Publicado 2021