Genome-wide nucleosome mapping of Plasmodium falciparum reveals histone-rich coding and histone-poor intergenic regions and chromatin remodeling of core and subtelomeric genes

por Westenberger, Scott J, Cui, Long, Dharia, Neekesh, Winzeler, Elizabeth, Cui, Liwang
Publicado 2009

Esterase mutation is a mechanism of resistance to antimalarial compounds

por Istvan, Eva S., Mallari, Jeremy P., Corey, Victoria C., Dharia, Neekesh V., Marshall, Garland R., Winzeler, Elizabeth A., Goldberg, Daniel E.
Publicado 2017

A Systems-Based Analysis of Plasmodium vivax Lifecycle Transcription from Human to Mosquito

por Westenberger, Scott J., McClean, Colleen M., Chattopadhyay, Rana, Dharia, Neekesh V., Carlton, Jane M., Barnwell, John W., Collins, William E., Hoffman, Stephen L., Zhou, Yingyao, Vinetz, Joseph M., Winzeler, Elizabeth A.
Publicado 2010

Transcriptional Plasticity Drives Leukemia Immune Escape

por Eagle, Kenneth, Harada, Taku, Kalfon, Jérémie, Perez, Monika W., Heshmati, Yaser, Ewers, Jazmin, Koren, Jošt Vrabič, Dempster, Joshua M., Kugener, Guillaume, Paralkar, Vikram R., Lin, Charles Y., Dharia, Neekesh V., Stegmaier, Kimberly, Orkin, Stuart H., Pimkin, Maxim
Publicado 2022

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

por Dharia, Neekesh V, Sidhu, Amar Bir Singh, Cassera, María Belén, Westenberger, Scott J, Bopp, Selina ER, Eastman, Rich T, Plouffe, David, Batalov, Serge, Park, Daniel J, Volkman, Sarah K, Wirth, Dyann F, Zhou, Yingyao, Fidock, David A, Winzeler, Elizabeth A
Publicado 2009

A Chemical Genomic Analysis of Decoquinate, a Plasmodium falciparum Cytochrome b Inhibitor

por Nam, Tae-gyu, McNamara, Case W., Bopp, Selina, Dharia, Neekesh V., Meister, Stephan, Bonamy, Ghislain M. C., Plouffe, David M., Kato, Nobutaka, McCormack, Susan, Bursulaya, Badry, Ke, Hangjun, Vaidya, Akhil B., Schultz, Peter G., Winzeler, Elizabeth A.
Publicado 2011

Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma

por Stolte, Björn, Iniguez, Amanda Balboni, Dharia, Neekesh V., Robichaud, Amanda L., Conway, Amy Saur, Morgan, Ann M., Alexe, Gabriela, Schauer, Nathan J., Liu, Xiaoxi, Bird, Gregory H., Tsherniak, Aviad, Vazquez, Francisca, Buhrlage, Sara J., Walensky, Loren D., Stegmaier, Kimberly
Publicado 2018

Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families

por Bopp, Selina E. R., Manary, Micah J., Bright, A. Taylor, Johnston, Geoffrey L., Dharia, Neekesh V., Luna, Fabio L., McCormack, Susan, Plouffe, David, McNamara, Case W., Walker, John R., Fidock, David A., Denchi, Eros Lazzerini, Winzeler, Elizabeth A.
Publicado 2013

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

por Durbin, Adam D., Zimmerman, Mark W., Dharia, Neekesh V., Abraham, Brian J., Iniguez, Amanda Balboni, Weichert-Leahey, Nina, He, Shuning, Krill-Burger, John M., Root, David E., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Golub, Todd R., Young, Richard A., Look, A. Thomas, Stegmaier, Kimberly
Publicado 2018

Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops

por Harada, Taku, Kalfon, Jérémie, Perez, Monika W., Eagle, Kenneth, Braes, Flora Dievenich, Batley, Rashad, Heshmati, Yaser, Ferrucio, Juliana Xavier, Ewers, Jazmin, Mehta, Stuti, Kossenkov, Andrew, Ellegast, Jana M., Bowker, Allyson, Wickramasinghe, Jayamanna, Nabet, Behnam, Paralkar, Vikram R., Dharia, Neekesh V., Stegmaier, Kimberly, Orkin, Stuart H., Pimkin, Maxim
Publicado 2023

TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma

por Seong, Bo Kyung A., Dharia, Neekesh V., Lin, Shan, Donovan, Katherine A., Chong, Shasha, Robichaud, Amanda, Conway, Amy, Hamze, Amanda, Ross, Linda, Alexe, Gabriela, Adane, Biniam, Nabet, Behnam, Ferguson, Fleur M., Stolte, Björn, Wang, Emily Jue, Sun, Jialin, Darzacq, Xavier, Piccioni, Federica, Gray, Nathanael S., Fischer, Eric S., Stegmaier, Kimberly
Publicado 2021

The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma

por Lu, Diana Y., Ellegast, Jana M., Ross, Kenneth N., Malone, Clare F., Lin, Shan, Mabe, Nathaniel W., Dharia, Neekesh V., Meyer, Ashleigh, Conway, Amy, Su, Angela H., Selich-Anderson, Julia, Taslim, Cenny, Byrum, Andrea K., Seong, Bo Kyung A., Adane, Biniam, Gray, Nathanael S., Rivera, Miguel N., Lessnick, Stephen L., Stegmaier, Kimberly
Publicado 2023

An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML

por Lin, Shan, Larrue, Clément, Scheidegger, Nastassja K., Seong, Bo Kyung A., Dharia, Neekesh V., Kuljanin, Miljan, Wechsler, Caroline S., Kugener, Guillaume, Robichaud, Amanda L., Conway, Amy Saur, Mashaka, Thelma, Mouche, Sarah, Adane, Biniam, Ryan, Jeremy A., Mancias, Joseph D., Younger, Scott T., Piccioni, Federica, Lee, Lynn H., Wunderlich, Mark, Letai, Anthony, Tamburini, Jérôme, Stegmaier, Kimberly
Publicado 2022

Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival

por Gillani, Riaz, Seong, Bo Kyung A., Crowdis, Jett, Conway, Jake R., Dharia, Neekesh V., Alimohamed, Saif, Haas, Brian J., Han, Kyuho, Park, Jihye, Dietlein, Felix, He, Meng Xiao, Imamovic, Alma, Ma, Clement, Bassik, Michael C., Boehm, Jesse S., Vazquez, Francisca, Gusev, Alexander, Liu, David, Janeway, Katherine A., McFarland, James M., Stegmaier, Kimberly, Van Allen, Eliezer M.
Publicado 2021

A First-Generation Pediatric Cancer Dependency Map

por Dharia, Neekesh V., Kugener, Guillaume, Guenther, Lillian M., Malone, Clare F., Durbin, Adam D., Hong, Andrew L., Howard, Thomas P., Bandopadhayay, Pratiti, Wechsler, Caroline S., Fung, Iris, Warren, Allison C., Dempster, Joshua M., Krill-Burger, John M., Paolella, Brenton R., Moh, Phoebe, Jha, Nishant, Tang, Andrew, Montgomery, Philip, Boehm, Jesse S., Hahn, William C., Roberts, Charles W. M., McFarland, James M., Tsherniak, Aviad, Golub, Todd R., Vazquez, Francisca, Stegmaier, Kimberly
Publicado 2021

A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

por Harada, Taku, Heshmati, Yaser, Kalfon, Jérémie, Perez, Monika W., Xavier Ferrucio, Juliana, Ewers, Jazmin, Hubbell Engler, Benjamin, Kossenkov, Andrew, Ellegast, Jana M., Yi, Joanna S., Bowker, Allyson, Zhu, Qian, Eagle, Kenneth, Liu, Tianxin, Kai, Yan, Dempster, Joshua M., Kugener, Guillaume, Wickramasinghe, Jayamanna, Herbert, Zachary T., Li, Charles H., Vrabič Koren, Jošt, Weinstock, David M., Paralkar, Vikram R., Nabet, Behnam, Lin, Charles Y., Dharia, Neekesh V., Stegmaier, Kimberly, Orkin, Stuart H., Pimkin, Maxim
Publicado 2022

Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells

por Meyers, Robin M., Bryan, Jordan G., McFarland, James M., Weir, Barbara A., Sizemore, Ann E., Xu, Han, Dharia, Neekesh V., Montgomery, Phillip G., Cowley, Glenn S., Pantel, Sasha, Goodale, Amy, Lee, Yenarae, Ali, Levi D., Jiang, Guozhi, Lubonja, Rakela, Harrington, William F., Strickland, Matthew, Wu, Ting, Hawes, Derek C., Zhivich, Victor A., Wyatt, Meghan R., Kalani, Zohra, Chang, Jaime J., Okamoto, Michael, Stegmaier, Kimberly, Golub, Todd R., Boehm, Jesse S., Vazquez, Francisca, Root, David E., Hahn, William C., Tsherniak, Aviad
Publicado 2017

EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

por Durbin, Adam D., Wang, Tingjian, Wimalasena, Virangika K., Zimmerman, Mark W., Li, Deyao, Dharia, Neekesh V., Mariani, Luca, Shendy, Noha A.M., Nance, Stephanie, Patel, Anand G., Shao, Ying, Mundada, Maya, Maxham, Lily, Park, Paul M.C., Sigua, Logan H., Morita, Ken, Conway, Amy Saur, Robichaud, Amanda L., Perez-Atayde, Antonio R., Bikowitz, Melissa J., Quinn, Taylor R., Wiest, Olaf, Easton, John, Schönbrunn, Ernst, Bulyk, Martha L., Abraham, Brian J., Stegmaier, Kimberly, Look, A. Thomas, Qi, Jun
Publicado 2022

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

por Neggers, Jasper E., Paolella, Brenton R., Asfaw, Adhana, Rothberg, Michael V., Skipper, Thomas A., Yang, Annan, Kalekar, Radha L., Krill-Burger, John M., Dharia, Neekesh V., Kugener, Guillaume, Kalfon, Jérémie, Yuan, Chen, Dumont, Nancy, Gonzalez, Alfredo, Abdusamad, Mai, Li, Yvonne Y., Spurr, Liam F., Wu, Westley W., Durbin, Adam D., Wolpin, Brian M., Piccioni, Federica, Root, David E., Boehm, Jesse S., Cherniack, Andrew D., Tsherniak, Aviad, Hong, Andrew L., Hahn, William C., Stegmaier, Kimberly, Golub, Todd R., Vazquez, Francisca, Aguirre, Andrew J.
Publicado 2020

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

por Neggers, Jasper E., Paolella, Brenton R., Asfaw, Adhana, Rothberg, Michael V., Skipper, Thomas A., Yang, Annan, Kalekar, Radha L., Krill-Burger, John M., Dharia, Neekesh V., Kugener, Guillaume, Kalfon, Jérémie, Yuan, Chen, Dumont, Nancy, Gonzalez, Alfredo, Abdusamad, Mai, Li, Yvonne Y., Spurr, Liam F., Wu, Westley W., Durbin, Adam D., Wolpin, Brain M., Piccioni, Federica, Root, David E., Boehm, Jesse S., Cherniack, Andrew D., Tsherniak, Aviad, Hong, Andrew L., Hahn, William C., Stegmaier, Kimberly, Golub, Todd R., Vazquez, Francisca, Aguirre, Andrew J.
Publicado 2021