Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR

por Yan, Wupeng, Markegard, Evan, Dharmaiah, Srisathiyanarayanan, Urisman, Anatoly, Drew, Matthew, Esposito, Dominic, Scheffzek, Klaus, Nissley, Dwight V., McCormick, Frank, Simanshu, Dhirendra K.
Publicado 2020

The small molecule BI-2852 induces a nonfunctional dimer of KRAS

por Tran, Timothy H., Alexander, Patrick, Dharmaiah, Srisathiyanarayanan, Agamasu, Constance, Nissley, Dwight V., McCormick, Frank, Esposito, Dominic, Simanshu, Dhirendra K., Stephen, Andrew G., Balius, Trent E.
Publicado 2020

Reduced dynamic complexity allows structure elucidation of an excited state of KRAS(G13D)

por Chao, Fa-An, Chan, Albert H., Dharmaiah, Srisathiyanarayanan, Schwieters, Charles D., Tran, Timothy H., Taylor, Troy, Ramakrishnan, Nitya, Esposito, Dominic, Nissley, Dwight V., McCormick, Frank, Simanshu, Dhirendra K., Cornilescu, Gabriel
Publicado 2023

Structures of N-terminally processed KRAS provide insight into the role of N-acetylation

por Dharmaiah, Srisathiyanarayanan, Tran, Timothy H., Messing, Simon, Agamasu, Constance, Gillette, William K., Yan, Wupeng, Waybright, Timothy, Alexander, Patrick, Esposito, Dominic, Nissley, Dwight V., McCormick, Frank, Stephen, Andrew G., Simanshu, Dhirendra K.
Publicado 2019

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

por Tran, Timothy H., Chan, Albert H., Young, Lucy C., Bindu, Lakshman, Neale, Chris, Messing, Simon, Dharmaiah, Srisathiyanarayanan, Taylor, Troy, Denson, John-Paul, Esposito, Dominic, Nissley, Dwight V., Stephen, Andrew G., McCormick, Frank, Simanshu, Dhirendra K.
Publicado 2021