Mechanistic insight into ligand binding to G-quadruplex DNA

por Di Leva, Francesco Saverio, Novellino, Ettore, Cavalli, Andrea, Parrinello, Michele, Limongelli, Vittorio
Publicado 2014

Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities

por Cannalire, Rolando, Cerchia, Carmen, Beccari, Andrea R., Di Leva, Francesco Saverio, Summa, Vincenzo
Publicado 2020

Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We?

por D’Annessa, Ilda, Di Leva, Francesco Saverio, La Teana, Anna, Novellino, Ettore, Limongelli, Vittorio, Di Marino, Daniele
Publicado 2020

Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism

por Di Leva, Francesco Saverio, Festa, Carmen, Renga, Barbara, Sepe, Valentina, Novellino, Ettore, Fiorucci, Stefano, Zampella, Angela, Limongelli, Vittorio
Publicado 2015

Click‐Chemistry (CuAAC) Trimerization of an α(v)β(6) Integrin Targeting Ga‐68‐Peptide: Enhanced Contrast for in‐Vivo PET Imaging of Human Lung Adenocarcinoma Xenografts

por Quigley, Neil Gerard, Tomassi, Stefano, di Leva, Francesco Saverio, Di Maro, Salvatore, Richter, Frauke, Steiger, Katja, Kossatz, Susanne, Marinelli, Luciana, Notni, Johannes
Publicado 2020

Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties

por Finamore, Claudia, Baronissi, Giuliana, Marchianò, Silvia, Di Leva, Francesco Saverio, Carino, Adriana, Monti, Maria Chiara, Limongelli, Vittorio, Zampella, Angela, Fiorucci, Stefano, Sepe, Valentina
Publicado 2019

Molecular View on the iRGD Peptide Binding Mechanism: Implications for Integrin Activity and Selectivity Profiles

por D’Amore, Vincenzo Maria, Donati, Greta, Lenci, Elena, Ludwig, Beatrice Stefanie, Kossatz, Susanne, Baiula, Monica, Trabocchi, Andrea, Kessler, Horst, Di Leva, Francesco Saverio, Marinelli, Luciana
Publicado 2023

Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists

por De Marino, Simona, Carino, Adriana, Masullo, Dario, Finamore, Claudia, Marchianò, Silvia, Cipriani, Sabrina, Di Leva, Francesco Saverio, Catalanotti, Bruno, Novellino, Ettore, Limongelli, Vittorio, Fiorucci, Stefano, Zampella, Angela
Publicado 2017

Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1

por Di Leva, Francesco Saverio, Festa, Carmen, Carino, Adriana, De Marino, Simona, Marchianò, Silvia, Di Marino, Daniele, Finamore, Claudia, Monti, Maria Chiara, Zampella, Angela, Fiorucci, Stefano, Limongelli, Vittorio
Publicado 2019

Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases

por Festa, Carmen, De Marino, Simona, Carino, Adriana, Sepe, Valentina, Marchianò, Silvia, Cipriani, Sabrina, Di Leva, Francesco S., Limongelli, Vittorio, Monti, Maria C., Capolupo, Angela, Distrutti, Eleonora, Fiorucci, Stefano, Zampella, Angela
Publicado 2017

Marine and Semi-Synthetic Hydroxysteroids as New Scaffolds for Pregnane X Receptor Modulation

por Sepe, Valentina, Di Leva, Francesco Saverio, D’Amore, Claudio, Festa, Carmen, De Marino, Simona, Renga, Barbara, D’Auria, Maria Valeria, Novellino, Ettore, Limongelli, Vittorio, D’Souza, Lisette, Majik, Mahesh, Zampella, Angela, Fiorucci, Stefano
Publicado 2014

The Inhibition of DNA Viruses by the Amphibian Antimicrobial Peptide Temporin G: A Virological Study Addressing HSV-1 and JPCyV

por Marcocci, Maria Elena, Jackowska, Bianka Gabriela, Prezioso, Carla, Protto, Virginia, De Angelis, Marta, Di Leva, Francesco Saverio, Casciaro, Bruno, Carotenuto, Alfonso, Mangoni, Maria Luisa, Palamara, Anna Teresa, Pietropaolo, Valeria, De Chiara, Giovanna, Nencioni, Lucia
Publicado 2022

Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structu...

por Stefanelli, Irina, Corona, Angela, Cerchia, Carmen, Cassese, Emilia, Improta, Salvatore, Costanzi, Elisa, Pelliccia, Sveva, Morasso, Stefano, Esposito, Francesca, Paulis, Annalaura, Scognamiglio, Sante, Di Leva, Francesco Saverio, Storici, Paola, Brindisi, Margherita, Tramontano, Enzo, Cannalire, Rolando, Summa, Vincenzo
Publicado 2023

Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand

por Tomassi, Stefano, D’Amore, Vincenzo Maria, Di Leva, Francesco Saverio, Vannini, Andrea, Quilici, Giacomo, Weinmüller, Michael, Reichart, Florian, Amato, Jussara, Romano, Barbara, Izzo, Angelo Antonio, Di Maro, Salvatore, Novellino, Ettore, Musco, Giovanna, Gianni, Tatiana, Kessler, Horst, Marinelli, Luciana
Publicado 2021

Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design

por Donati, Greta, D’Amore, Vincenzo Maria, Russomanno, Pasquale, Cerofolini, Linda, Amato, Jussara, Marzano, Simona, Salobehaj, Maria, Rizzo, Domenico, Assoni, Giulia, Carotenuto, Alfonso, La Pietra, Valeria, Arosio, Daniela, Seneci, Pierfausto, Fragai, Marco, Brancaccio, Diego, Di Leva, Francesco Saverio, Marinelli, Luciana
Publicado 2023

Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase

por Costi, Roberta, Métifiot, Mathieu, Chung, Suhman, Cuzzucoli Crucitti, Giuliana, Maddali, Kasthuraiah, Pescatori, Luca, Messore, Antonella, Madia, Valentina Noemi, Pupo, Giovanni, Scipione, Luigi, Tortorella, Silvano, Di Leva, Francesco Saverio, Cosconati, Sandro, Marinelli, Luciana, Novellino, Ettore, Le Grice, Stuart F. J., Corona, Angela, Pommier, Yves, Marchand, Christophe, Di Santo, Roberto
Publicado 2014