A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Imidazolopiperazine KAF156 To Assess Its Safety, Tolerability...

por Leong, F. Joel, Zhao, Rong, Zeng, Shuqi, Magnusson, Baldur, Diagana, Thierry T., Pertel, Peter
Publicado 2014

A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel spiroindolone KAE609, to assess the safety, tolerability and...

por Leong, Joel, Li, Ruobing, Jain, Jay Prakash, Lefèvre, Gilbert, Magnusson, Baldur, Diagana, Thierry, Pertel, Peter
Publicado 2014

A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Antimalarial Spiroindolone KAE609 (Cipargamin) To Assess Its...

por Leong, F. Joel, Li, Ruobing, Jain, Jay Prakash, Lefèvre, Gilbert, Magnusson, Baldur, Diagana, Thierry T., Pertel, Peter
Publicado 2014

Na(+) Regulation in the Malaria Parasite Plasmodiumfalciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials

por Spillman, Natalie J., Allen, Richard J.W., McNamara, Case W., Yeung, Bryan K.S., Winzeler, Elizabeth A., Diagana, Thierry T., Kirk, Kiaran
Publicado 2013

Use-case scenarios for an anti-Cryptosporidium therapeutic

por Ashigbie, Paul G., Shepherd, Susan, Steiner, Kevin L., Amadi, Beatrice, Aziz, Natasha, Manjunatha, Ujjini H., Spector, Jonathan M., Diagana, Thierry T., Kelly, Paul
Publicado 2021

Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model

por Lakshminarayana, Suresh B., Freymond, Céline, Fischli, Christoph, Yu, Jing, Weber, Sebastian, Goh, Anne, Yeung, Bryan K. S., Ho, Paul C., Dartois, Véronique, Diagana, Thierry T., Rottmann, Matthias, Blasco, Francesca
Publicado 2015

Imidazolopiperazines Kill both Rings and Dormant Rings in Wild-Type and K13 Artemisinin-Resistant Plasmodium falciparum In Vitro

por Dembele, Laurent, Gupta, Devendra Kumar, Lim, Michelle Yi-Xiu, Ang, Xiaoman, Selva, Jeremy J., Chotivanich, Kesinee, Nguon, Chea, Dondorp, Arjen M., Bonamy, Ghislain M. C., Diagana, Thierry T., Bifani, Pablo
Publicado 2018

Transcriptional profiling of hepatocytes infected with the replicative form of the malaria parasite Plasmodium cynomolgi

por Mitchell, Gabriel, Roma, Guglielmo, Voorberg-van der Wel, Annemarie, Beibel, Martin, Zeeman, Anne-Marie, Schuierer, Sven, Torres, Laura, Flannery, Erika L., Kocken, Clemens H. M., Mikolajczak, Sebastian A., Diagana, Thierry T.
Publicado 2022

Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis

por Rao, Srinivasa P S, Lakshminarayana, Suresh B, Jiricek, Jan, Kaiser, Marcel, Ritchie, Ryan, Myburgh, Elmarie, Supek, Frantisek, Tuntland, Tove, Nagle, Advait, Molteni, Valentina, Mäser, Pascal, Mottram, Jeremy C, Barrett, Michael P, Diagana, Thierry T
Publicado 2020

Opportunities and Challenges in Developing a Cryptosporidium Controlled Human Infection Model for Testing Antiparasitic Agents

por Jumani, Rajiv S., Blais, Johanne, Tillmann, Hanns-Christian, Segal, Florencia, Wetty, Dean, Ostermeier, Christian, Nuber, Natko, Lakshman, Jay, Aziz, Natasha, Chandra, Richa, Chen, Wilbur H., Chappell, Cynthia L., Diagana, Thierry T., Manjunatha, Ujjini H.
Publicado 2021

PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites

por Zeeman, Anne-Marie, Lakshminarayana, Suresh B., van der Werff, Nicole, Klooster, Els J., Voorberg-van der Wel, Annemarie, Kondreddi, Ravinder R., Bodenreider, Christophe, Simon, Oliver, Sauerwein, Robert, Yeung, Bryan K. S., Diagana, Thierry T., Kocken, Clemens H. M.
Publicado 2016

A dual fluorescent Plasmodium cynomolgi reporter line reveals in vitro malaria hypnozoite reactivation

por Voorberg-van der Wel, Annemarie M., Zeeman, Anne-Marie, Nieuwenhuis, Ivonne G., van der Werff, Nicole M., Klooster, Els J., Klop, Onny, Vermaat, Lars C., Kumar Gupta, Devendra, Dembele, Laurent, Diagana, Thierry T., Kocken, Clemens H. M.
Publicado 2020

The Plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development

por Gupta, Devendra Kumar, Dembele, Laurent, Voorberg-van der Wel, Annemarie, Roma, Guglielmo, Yip, Andy, Chuenchob, Vorada, Kangwanrangsan, Niwat, Ishino, Tomoko, Vaughan, Ashley M, Kappe, Stefan H, Flannery, Erika L, Sattabongkot, Jetsumon, Mikolajczak, Sebastian, Bifani, Pablo, Kocken, Clemens HM, Diagana, Thierry Tidiane
Publicado 2019

A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi

por Voorberg-van der Wel, Annemarie, Roma, Guglielmo, Gupta, Devendra Kumar, Schuierer, Sven, Nigsch, Florian, Carbone, Walter, Zeeman, Anne-Marie, Lee, Boon Heng, Hofman, Sam O, Faber, Bart W, Knehr, Judith, Pasini, Erica, Kinzel, Bernd, Bifani, Pablo, Bonamy, Ghislain M C, Bouwmeester, Tewis, Kocken, Clemens H M, Diagana, Thierry Tidiane
Publicado 2017

UDP-galactose and Acetyl-CoA transporters as Plasmodium multidrug resistance genes

por Lim, Michelle Yi-Xiu, LaMonte, Gregory, Lee, Marcus C.S., Reimer, Christin, Tan, Bee Huat, Corey, Victoria, Tjahjadi, Bianca F., Chua, Adeline, Nachon, Marie, Wintjens, René, Gedeck, Peter, Malleret, Benoit, Renia, Laurent, Bonamy, Ghislain M.C., Ho, Paul Chi-Lui, Yeung, Bryan K. S., Chow, Eric D., Lim, Liting, Fidock, David A., Diagana, Thierry T., Winzeler, Elizabeth A., Bifani, Pablo
Publicado 2016

Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria

por Yeung, Bryan K. S., Zou, Bin, Rottmann, Matthias, Lakshminarayana, Suresh B., Ang, Shi Hua, Leong, Seh Yong, Tan, Jocelyn, Wong, Josephine, Keller-Maerki, Sonja, Fischli, Christoph, Goh, Anne, Schmitt, Esther K., Krastel, Philipp, Francotte, Eric, Kuhen, Kelli, Plouffe, David, Henson, Kerstin, Wagner, Trixie, Winzeler, Elizabeth A., Petersen, Frank, Brun, Reto, Dartois, Veronique, Diagana, Thierry T., Keller, Thomas H.
Publicado 2010

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

por Saldivia, Manuel, Fang, Eric, Ma, Xiaolei, Myburgh, Elmarie, Carnielli, Juliana B. T., Bower-Lepts, Christopher, Brown, Elaine, Ritchie, Ryan, Lakshminarayana, Suresh B., Chen, Yen-Liang, Patra, Debjani, Ornelas, Elizabeth, Koh, Hazel X. Y., Williams, Sarah, Supek, Frantisek, Paape, Daniel, McCulloch, Richard, Kaiser, Marcel, Barrett, Michael P., Jiricek, Jan, Diagana, Thierry T., Mottram, Jeremy C., Rao, Srinivasa P.S.
Publicado 2020

Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin

por Hoepfner, Dominic, McNamara, Case W., Lim, Chek Shik, Studer, Christian, Riedl, Ralph, Aust, Thomas, McCormack, Susan L., Plouffe, David M., Meister, Stephan, Schuierer, Sven, Plikat, Uwe, Hartmann, Nicole, Staedtler, Frank, Cotesta, Simona, Schmitt, Esther K., Petersen, Frank, Supek, Frantisek, Glynne, Richard J., Tallarico, John A., Porter, Jeffrey A., Fishman, Mark C., Bodenreider, Christophe, Diagana, Thierry T., Movva, N. Rao, Winzeler, Elizabeth A.
Publicado 2012

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis

por Manjunatha, Ujjini H., Vinayak, Sumiti, Zambriski, Jennifer A., Chao, Alexander T., Sy, Tracy, Noble, Christian G., Bonamy, Ghislain M. C., Kondreddi, Ravinder R., Zou, Bin, Gedeck, Peter, Brooks, Carrie F., Herbert, Gillian T., Sateriale, Adam, Tandel, Jayesh, Noh, Susan, Lakshminarayana, Suresh B., Lim, Siau H., Goodman, Laura B., Bodenreider, Christophe, Feng, Gu, Zhang, Lijun, Blasco, Francesca, Wagner, Juergen, Leong, F. Joel, Striepen, Boris, Diagana, Thierry T.
Publicado 2017

Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy

por Bertschi, Nicole L, Voorberg-van der Wel, Annemarie, Zeeman, Anne-Marie, Schuierer, Sven, Nigsch, Florian, Carbone, Walter, Knehr, Judith, Gupta, Devendra K, Hofman, Sam O, van der Werff, Nicole, Nieuwenhuis, Ivonne, Klooster, Els, Faber, Bart W, Flannery, Erika L, Mikolajczak, Sebastian A, Chuenchob, Vorada, Shrestha, Binesh, Beibel, Martin, Bouwmeester, Tewis, Kangwanrangsan, Niwat, Sattabongkot, Jetsumon, Diagana, Thierry T, Kocken, Clemens HM, Roma, Guglielmo
Publicado 2018