Bioisosteric Replacement as a Tool in Anti-HIV Drug Design

por Dick, Alexej, Cocklin, Simon
Publicado 2020

Recent Advances in HIV-1 Gag Inhibitor Design and Development

por Dick, Alexej, Cocklin, Simon
Publicado 2020

Subtype Differences in the Interaction of HIV-1 Matrix with Calmodulin: Implications for Biological Functions

por Dick, Alexej, Cocklin, Simon
Publicado 2021

Clade-Specific Alterations within the HIV-1 Capsid Protein with Implications for Nuclear Translocation

por Dick, Alexej, Meuser, Megan E., Cocklin, Simon
Publicado 2022

New RAD51 Inhibitors to Target Homologous Recombination in Human Cells

por Shkundina, Irina S., Gall, Alexander A., Dick, Alexej, Cocklin, Simon, Mazin, Alexander V.
Publicado 2021

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor

por Meuser, Megan E., Rashad, Adel A., Ozorowski, Gabriel, Dick, Alexej, Ward, Andrew B., Cocklin, Simon
Publicado 2019

Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein

por Olal, Daniel, Dick, Alexej, Woods, Virgil L., Liu, Tong, Li, Sheng, Devignot, Stephanie, Weber, Friedemann, Saphire, Erica Ollmann, Daumke, Oliver
Publicado 2014

Copper Modulates the Catalytic Activity of Protein Kinase CK2

por Chojnowski, John E., Li, Rongrong, Tsang, Tiffany, Alfaran, Fatimah H., Dick, Alexej, Cocklin, Simon, Brady, Donita C., Strochlic, Todd I.
Publicado 2022

Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

por Zhang, Shiyu, Holmes, Andrew P., Dick, Alexej, Rashad, Adel A., Enríquez Rodríguez, Lucía, Canziani, Gabriela A., Root, Michael J., Chaiken, Irwin M.
Publicado 2021

Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators

por Zhang, Xujie, Sun, Lin, Xu, Shujing, Shao, Xiaoyu, Li, Ziyi, Ding, Dang, Jiang, Xiangyi, Zhao, Shujie, Cocklin, Simon, Clercq, Erik De, Pannecouque, Christophe, Dick, Alexej, Liu, Xinyong, Zhan, Peng
Publicado 2022

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors

por Jiang, Xiangyi, Wu, Gaochan, Zalloum, Waleed A., Meuser, Megan E., Dick, Alexej, Sun, Lin, Chen, Chin-Ho, Kang, Dongwei, Jing, Lanlan, Jia, Ruifang, Cocklin, Simon, Lee, Kuo-Hsiung, Liu, Xinyong, Zhan, Peng
Publicado 2019

Design, Synthesis and Structure—Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction

por Ji, Xiangkai, Li, Jing, Sharma, Prem Prakash, Jiang, Xiangyi, Rathi, Brijesh, Gao, Zhen, Hu, Lide, Kang, Dongwei, De Clercq, Erik, Cocklin, Simon, Liu, Chuanfeng, Pannecouque, Christophe, Dick, Alexej, Liu, Xinyong, Zhan, Peng
Publicado 2022

Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators

por Xu, Shujing, Sun, Lin, Zalloum, Waleed A., Huang, Tianguang, Zhang, Xujie, Ding, Dang, Shao, Xiaoyu, Jiang, Xiangyi, Zhao, Fabao, Cocklin, Simon, De Clercq, Erik, Pannecouque, Christophe, Dick, Alexej, Liu, Xinyong, Zhan, Peng
Publicado 2022