CDK4 inhibition diminishes p53 activation by MDM2 antagonists

por Sriraman, Anusha, Dickmanns, Antje, Najafova, Zeynab, Johnsen, Steven A., Dobbelstein, Matthias
Publicado 2018

CDK4/6 inhibition confers protection of normal gut epithelia against gemcitabine and the active metabolite of irinotecan

por Blume, Joshua, Claus, Luisa, Isermann, Tamara, Dickmanns, Antje, Conradi, Lena-Christin, Schulz-Heddergott, Ramona, Dobbelstein, Matthias
Publicado 2023

N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody

por Zibat, Arne, Zhang, Xiaoxiao, Dickmanns, Antje, Stegmann, Kim M., Dobbelstein, Adrian W., Alachram, Halima, Soliwoda, Rebecca, Salinas, Gabriela, Groß, Uwe, Görlich, Dirk, Kschischo, Maik, Wollnik, Bernd, Dobbelstein, Matthias
Publicado 2023

The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models

por Stegmann, Kim M., Dickmanns, Antje, Gerber, Sabrina, Nikolova, Vella, Klemke, Luisa, Manzini, Valentina, Schlösser, Denise, Bierwirth, Cathrin, Freund, Julia, Sitte, Maren, Lugert, Raimond, Salinas, Gabriela, Meister, Toni Luise, Pfaender, Stephanie, Görlich, Dirk, Wollnik, Bernd, Groß, Uwe, Dobbelstein, Matthias
Publicado 2021

Neutralization of SARS‐CoV‐2 by highly potent, hyperthermostable, and mutation‐tolerant nanobodies

por Güttler, Thomas, Aksu, Metin, Dickmanns, Antje, Stegmann, Kim M., Gregor, Kathrin, Rees, Renate, Taxer, Waltraud, Rymarenko, Oleh, Schünemann, Jürgen, Dienemann, Christian, Gunkel, Philip, Mussil, Bianka, Krull, Jens, Teichmann, Ulrike, Groß, Uwe, Cordes, Volker C, Dobbelstein, Matthias, Görlich, Dirk
Publicado 2021

Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication

por Stegmann, Kim M., Dickmanns, Antje, Heinen, Natalie, Blaurock, Claudia, Karrasch, Tim, Breithaupt, Angele, Klopfleisch, Robert, Uhlig, Nadja, Eberlein, Valentina, Issmail, Leila, Herrmann, Simon T., Schreieck, Amelie, Peelen, Evelyn, Kohlhof, Hella, Sadeghi, Balal, Riek, Alexander, Speakman, John R., Groß, Uwe, Görlich, Dirk, Vitt, Daniel, Müller, Thorsten, Grunwald, Thomas, Pfaender, Stephanie, Balkema-Buschmann, Anne, Dobbelstein, Matthias
Publicado 2022