The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling

por Chakraborty, Atanu, Diefenbacher, Markus E., Mylona, Anastasia, Kassel, Olivier, Behrens, Axel
Publicado 2015

USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell Carcinoma

por Prieto-Garcia, Cristian, Tomašković, Ines, Shah, Varun Jayeshkumar, Dikic, Ivan, Diefenbacher, Markus
Publicado 2021

The LIM Domain Protein nTRIP6 Recruits the Mediator Complex to AP-1-Regulated Promoters

por Diefenbacher, Markus E., Reich, Daniela, Dahley, Oliver, Kemler, Denise, Litfin, Margarethe, Herrlich, Peter, Kassel, Olivier
Publicado 2014

RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

por Fritsch, Ralph, de Krijger, Inge, Fritsch, Kornelia, George, Roger, Reason, Beth, Kumar, Madhu S., Diefenbacher, Markus, Stamp, Gordon, Downward, Julian
Publicado 2013

Autophagy Blockage Reduces the Incidence of Pancreatic Ductal Adenocarcinoma in the Context of Mutant Trp53

por Mainz, Laura, Sarhan, Mohamed A. F. E., Roth, Sabine, Sauer, Ursula, Maurus, Katja, Hartmann, Elena M., Seibert, Helen-Desiree, Rosenwald, Andreas, Diefenbacher, Markus E., Rosenfeldt, Mathias T.
Publicado 2022

Intestinal Epithelial Barrier Maturation by Enteric Glial Cells Is GDNF-Dependent

por Meir, Michael, Kannapin, Felix, Diefenbacher, Markus, Ghoreishi, Yalda, Kollmann, Catherine, Flemming, Sven, Germer, Christoph-Thomas, Waschke, Jens, Leven, Patrick, Schneider, Reiner, Wehner, Sven, Burkard, Natalie, Schlegel, Nicolas
Publicado 2021

Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway

por Prieto-Garcia, Cristian, Hartmann, Oliver, Reissland, Michaela, Fischer, Thomas, Maier, Carina R., Rosenfeldt, Mathias, Schülein-Völk, Christina, Klann, Kevin, Kalb, Reinhard, Dikic, Ivan, Münch, Christian, Diefenbacher, Markus E.
Publicado 2021

RsfA (YbeB) Proteins Are Conserved Ribosomal Silencing Factors

por Häuser, Roman, Pech, Markus, Kijek, Jaroslaw, Yamamoto, Hiroshi, Titz, Björn, Naeve, Florian, Tovchigrechko, Andrey, Yamamoto, Kaori, Szaflarski, Witold, Takeuchi, Nono, Stellberger, Thorsten, Diefenbacher, Markus E., Nierhaus, Knud H., Uetz, Peter
Publicado 2012

Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance

por Castellano, Esther, Sheridan, Clare, Thin, May Zaw, Nye, Emma, Spencer-Dene, Bradley, Diefenbacher, Markus E., Moore, Christopher, Kumar, Madhu S., Murillo, Miguel M., Grönroos, Eva, Lassailly, Francois, Stamp, Gordon, Downward, Julian
Publicado 2013

RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival

por Novak, Rostislav, Ahmad, Yamen Abu, Timaner, Michael, Bitman-Lotan, Eliya, Oknin-Vaisman, Avital, Horwitz, Roi, Hartmann, Oliver, Reissland, Michaela, Buck, Viktoria, Rosenfeldt, Mathias, Nikomarov, David, Diefenbacher, Markus Elmar, Shaked, Yuval, Orian, Amir
Publicado 2022

JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer

por Ruiz, E. Josue, Lan, Linxiang, Diefenbacher, Markus Elmar, Riising, Eva Madi, Da Costa, Clive, Chakraborty, Atanu, Hoeck, Joerg D., Spencer-Dene, Bradley, Kelly, Gavin, David, Jean-Pierre, Nye, Emma, Downward, Julian, Behrens, Axel
Publicado 2021

DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma

por Strubel, Alexander, Münick, Philipp, Hartmann, Oliver, Chaikuad, Apirat, Dreier, Birgit, Schaefer, Jonas V., Gebel, Jakob, Osterburg, Christian, Tuppi, Marcel, Schäfer, Birgit, Buck, Viktoria, Rosenfeldt, Mathias, Knapp, Stefan, Plückthun, Andreas, Diefenbacher, Markus E., Dötsch, Volker
Publicado 2023

USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K

por Prieto‐Garcia, Cristian, Hartmann, Oliver, Reissland, Michaela, Braun, Fabian, Bozkurt, Süleyman, Pahor, Nikolett, Fuss, Carmina, Schirbel, Andreas, Schülein‐Völk, Christina, Buchberger, Alexander, Calzado Canale, Marco A., Rosenfeldt, Mathias, Dikic, Ivan, Münch, Christian, Diefenbacher, Markus E.
Publicado 2022

RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells

por Otto, Christoph, Kastner, Carolin, Schmidt, Stefanie, Uttinger, Konstantin, Baluapuri, Apoorva, Denk, Sarah, Rosenfeldt, Mathias T., Rosenwald, Andreas, Roehrig, Florian, Ade, Carsten P., Schuelein‐Voelk, Christina, Diefenbacher, Markus E., Germer, Christoph‐Thomas, Wolf, Elmar, Eilers, Martin, Wiegering, Armin
Publicado 2022

LUBAC determines chemotherapy resistance in squamous cell lung cancer

por Ruiz, E. Josue, Diefenbacher, Markus E., Nelson, Jessica K., Sancho, Rocio, Pucci, Fabio, Chakraborty, Atanu, Moreno, Paula, Annibaldi, Alessandro, Liccardi, Gianmaria, Encheva, Vesela, Mitter, Richard, Rosenfeldt, Mathias, Snijders, Ambrosius P., Meier, Pascal, Calzado, Marco A., Behrens, Axel
Publicado 2019

Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells

por Prieto‐Garcia, Cristian, Hartmann, Oliver, Reissland, Michaela, Braun, Fabian, Fischer, Thomas, Walz, Susanne, Schülein‐Völk, Christina, Eilers, Ursula, Ade, Carsten P, Calzado, Marco A, Orian, Amir, Maric, Hans M, Münch, Christian, Rosenfeldt, Mathias, Eilers, Martin, Diefenbacher, Markus E
Publicado 2020

PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy

por Fischer, Thomas, Hartmann, Oliver, Reissland, Michaela, Prieto-Garcia, Cristian, Klann, Kevin, Pahor, Nikolett, Schülein-Völk, Christina, Baluapuri, Apoorva, Polat, Bülent, Abazari, Arya, Gerhard-Hartmann, Elena, Kopp, Hans-Georg, Essmann, Frank, Rosenfeldt, Mathias, Münch, Christian, Flentje, Michael, Diefenbacher, Markus E.
Publicado 2022

Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease

por Hartmann, Oliver, Reissland, Michaela, Maier, Carina R., Fischer, Thomas, Prieto-Garcia, Cristian, Baluapuri, Apoorva, Schwarz, Jessica, Schmitz, Werner, Garrido-Rodriguez, Martin, Pahor, Nikolett, Davies, Clare C., Bassermann, Florian, Orian, Amir, Wolf, Elmar, Schulze, Almut, Calzado, Marco A., Rosenfeldt, Mathias T., Diefenbacher, Markus E.
Publicado 2021

USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer

por Maier, Carina R., Hartmann, Oliver, Prieto-Garcia, Cristian, Al-Shami, Kamal M., Schlicker, Lisa, Vogel, Felix C. E., Haid, Silke, Klann, Kevin, Buck, Viktoria, Münch, Christian, Schmitz, Werner, Einig, Elias, Krenz, Bastian, Calzado, Marco A., Eilers, Martin, Popov, Nikita, Rosenfeldt, Mathias T., Diefenbacher, Markus E., Schulze, Almut
Publicado 2023

A MYC/GCN2/eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer

por Schmidt, Stefanie, Gay, David, Uthe, Friedrich Wilhelm, Denk, Sarah, Paauwe, Madelon, Matthes, Niels, Diefenbacher, Markus Elmar, Bryson, Sheila, Warrander, Fiona Clare, Erhard, Florian, Ade, Carsten Patrick, Baluapuri, Apoorva, Walz, Susanne, Jackstadt, Rene, Ford, Catriona, Vlachogiannis, Georgios, Valeri, Nicola, Otto, Christoph, Schülein-Völk, Christina, Maurus, Katja, Schmitz, Werner, Knight, John Raymond Philip, Wolf, Elmar, Strathdee, Douglas, Schulze, Almut, Germer, Christoph-Thomas, Rosenwald, Andreas, Sansom, Owen James, Eilers, Martin, Wiegering, Armin
Publicado 2019