Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

por Dietzen, Noah M, Arcario, Mark J, Chen, Lawrence J, Petroff, John T, Moreland, K Trent, Krishnan, Kathiresan, Brannigan, Grace, Covey, Douglas F, Cheng, Wayland WL
Publicado 2022

Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation

por Petroff, John T., Dietzen, Noah M., Santiago-McRae, Ezry, Deng, Brett, Washington, Maya S., Chen, Lawrence J., Trent Moreland, K., Deng, Zengqin, Rau, Michael, Fitzpatrick, James A. J., Yuan, Peng, Joseph, Thomas T., Hénin, Jérôme, Brannigan, Grace, Cheng, Wayland W. L.
Publicado 2022