ClpXP protease targets long-lived DNA translocation states of a helicase-like motor to cause restriction alleviation

por Simons, Michelle, Diffin, Fiona M., Szczelkun, Mark D.
Publicado 2014

The Type ISP Restriction–Modification enzymes LlaBIII and LlaGI use a translocation–collision mechanism to cleave non-specific DNA distant from their recognition sites

por Šišáková, Eva, van Aelst, Kara, Diffin, Fiona M., Szczelkun, Mark D.
Publicado 2013

DNA cleavage and methylation specificity of the single polypeptide restriction–modification enzyme LlaGI

por Smith, Rachel M., Diffin, Fiona M., Savery, Nigel J., Josephsen, Jytte, Szczelkun, Mark D.
Publicado 2009

CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage

por Naqvi, Mohsin M., Lee, Laura, Montaguth, Oscar E. Torres, Diffin, Fiona M., Szczelkun, Mark D.
Publicado 2022

ENDO-Pore: high-throughput linked-end mapping of single DNA cleavage events using nanopore sequencing

por Torres Montaguth, Oscar E, Cross, Stephen J, Ingram, Kincaid W A, Lee, Laura, Diffin, Fiona M, Szczelkun, Mark D
Publicado 2021

Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes

por Chand, Mahesh Kumar, Nirwan, Neha, Diffin, Fiona M., van Aelst, Kara, Kulkarni, Manasi, Pernstich, Christian, Szczelkun, Mark D., Saikrishnan, Kayarat
Publicado 2015

5′ modifications to CRISPR–Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage

por Mullally, Grace, van Aelst, Kara, Naqvi, Mohsin M, Diffin, Fiona M, Karvelis, Tautvydas, Gasiunas, Giedrius, Siksnys, Virginijus, Szczelkun, Mark D
Publicado 2020