Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing

por Nguyen Tran, Minh Thuan, Mohd Khalid, Mohd Khairul Nizam, Wang, Qi, Walker, Jacqueline K. R., Lidgerwood, Grace E., Dilworth, Kimberley L., Lisowski, Leszek, Pébay, Alice, Hewitt, Alex W.
Publicado 2020

Efficient in vivo editing of OTC-deficient patient-derived primary human hepatocytes

por Ginn, Samantha L., Amaya, Anais K., Liao, Sophia H.Y., Zhu, Erhua, Cunningham, Sharon C., Lee, Michael, Hallwirth, Claus V., Logan, Grant J., Tay, Szun S., Cesare, Anthony J., Pickett, Hilda A., Grompe, Markus, Dilworth, Kimberley, Lisowski, Leszek, Alexander, Ian E.
Publicado 2019

Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality

por Cabanes-Creus, Marti, Ginn, Samantha L., Amaya, Anais K., Liao, Sophia H.Y., Westhaus, Adrian, Hallwirth, Claus V., Wilmott, Patrick, Ward, Jason, Dilworth, Kimberley L., Santilli, Giorgia, Rybicki, Arkadiusz, Nakai, Hiroyuki, Thrasher, Adrian J., Filip, Adrian C., Alexander, Ian E., Lisowski, Leszek
Publicado 2018

Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2

por Cabanes-Creus, Marti, Westhaus, Adrian, Navarro, Renina Gale, Baltazar, Grober, Zhu, Erhua, Amaya, Anais K., Liao, Sophia H.Y., Scott, Suzanne, Sallard, Erwan, Dilworth, Kimberley L., Rybicki, Arkadiusz, Drouyer, Matthieu, Hallwirth, Claus V., Bennett, Antonette, Santilli, Giorgia, Thrasher, Adrian J., Agbandje-McKenna, Mavis, Alexander, Ian E., Lisowski, Leszek
Publicado 2020

Assessment of Pre-Clinical Liver Models Based on Their Ability to Predict the Liver-Tropism of Adeno-Associated Virus Vectors

por Westhaus, Adrian, Cabanes-Creus, Marti, Dilworth, Kimberley L., Zhu, Erhua, Salas Gómez, David, Navarro, Renina G., Amaya, Anais K., Scott, Suzanne, Kwiatek, Magdalena, McCorkindale, Alexandra L., Hayman, Tara E., Frahm, Silke, Perocheau, Dany P., Tran, Bang Manh, Vincan, Elizabeth, Wong, Sharon L., Waters, Shafagh A., Riddiough, Georgina E., Perini, Marcos V., Wilson, Laurence O.W., Baruteau, Julien, Diecke, Sebastian, González-Aseguinolaza, Gloria, Santilli, Giorgia, Thrasher, Adrian J., Alexander, Ian E., Lisowski, Leszek
Publicado 2023