Protein Prenylation: Enzymes, Therapeutics, and Biotechnology Applications

por Palsuledesai, Charuta C., Distefano, Mark D.
Publicado 2014

Site-Specific PEGylation of Therapeutic Proteins

por Dozier, Jonathan K., Distefano, Mark D.
Publicado 2015

Rapid Analysis of Protein Farnesyltransferase Substrate Specificity Using Peptide Libraries and Isoprenoid Diphosphate Analogues

por Wang, Yen-Chih, Dozier, Jonathan K., Beese, Lorena S., Distefano, Mark D.
Publicado 2014

Effect of Currently Approved Carriers and Adjuvants on the Pre-Clinical Efficacy of a Conjugate Vaccine against Oxycodone in Mice and Rats

por Pravetoni, Marco, Vervacke, Jeffrey S., Distefano, Mark D., Tucker, Ashli M., Laudenbach, Megan, Pentel, Paul R.
Publicado 2014

Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue

por Suazo, Kiall F., Schaber, Chad, Palsuledesai, Charuta C., Odom John, Audrey R., Distefano, Mark D.
Publicado 2016

Diazirine-Containing Photoactivatable Isoprenoid: Synthesis and Application in Studies with Isoprenylcysteine Carboxyl Methyltransferase

por Vervacke, Jeffrey S., Funk, Amy L., Wang, Yen-Chih, Strom, Mark, Hrycyna, Christine A., Distefano, Mark D.
Publicado 2014

Metabolic labeling with an alkyne probe reveals similarities and differences in the prenylomes of several brain-derived cell lines and primary cells

por Suazo, Kiall F., Jeong, Angela, Ahmadi, Mina, Brown, Caroline, Qu, Wenhui, Li, Ling, Distefano, Mark D.
Publicado 2021

Engineering Protein Farnesyltransferase for Enzymatic Protein Labeling Applications

por Dozier, Jonathan K., Khatwani, Santoshkumar L., Wollack, James W., Wang, Yen-Chih, Schmidt-Dannert, Claudia, Distefano, Mark D.
Publicado 2014

Synthesis of Site-Specific DNA–Protein Conjugates and Their Effects on DNA Replication

por Yeo, Jung Eun, Wickramaratne, Susith, Khatwani, Santoshkumar, Wang, Yen-Chih, Vervacke, Jeffrey, Distefano, Mark D., Tretyakova, Natalia Y.
Publicado 2014

Engineering reversible cell–cell interactions using enzymatically lipidated chemically self-assembled nanorings

por Wang, Yiao, Kilic, Ozgun, Csizmar, Clifford M., Ashok, Sudhat, Hougland, James L., Distefano, Mark D., Wagner, Carston R.
Publicado 2020

Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy

por Zhang, Yi, Wang, Yiao, Uslu, Safak, Venkatachalapathy, Sneha, Rashidian, Mohammad, Schaefer, Jonas V., Plückthun, Andreas, Distefano, Mark D.
Publicado 2022

a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity

por Diaz-Rodriguez, Veronica, Hsu, Erh-Ting, Ganusova, Elena, Werst, Elena R., Becker, Jeffrey M., Hrycyna, Christine A., Distefano, Mark D.
Publicado 2017

Nitrodibenzofuran: A One- and Two-Photon Sensitive Protecting Group That Is Superior to Brominated Hydroxycoumarin for Thiol Caging in Peptides

por Mahmoodi, M. Mohsen, Abate-Pella, Daniel, Pundsack, Tom J., Palsuledesai, Charuta C., Goff, Philip C., Blank, David A., Distefano, Mark D.
Publicado 2016

MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase

por Schey, Garrett L., Buttery, Peter H., Hildebrandt, Emily R., Novak, Sadie X., Schmidt, Walter K., Hougland, James L., Distefano, Mark D.
Publicado 2021

Thinking outside the CaaX-box: an unusual reversible prenylation on ALDH9A1

por Suazo, Kiall F., Bělíček, Jakub, Schey, Garrett L., Auger, Shelby A., Petre, Alexandru M., Li, Ling, Błażewska, Katarzyna M., Kopečný, David, Distefano, Mark D.
Publicado 2023

GTPase splice variants RAC1 and RAC1B display isoform-specific differences in localization, prenylation, and interaction with the chaperone protein SmgGDS

por Koehn, Olivia J., Lorimer, Ellen, Unger, Bethany, Harris, Ra’Mal, Das, Akansha S., Suazo, Kiall F., Auger, Shelby A., Distefano, Mark D., Prokop, Jeremy W., Williams, Carol L.
Publicado 2023

Metabolic Labeling with an Alkyne-modified Isoprenoid Analog Facilitates Imaging and Quantification of the Prenylome in Cells

por Palsuledesai, Charuta C., Ochocki, Joshua D., Kuhns, Michelle M., Wang, Yen-Chih, Warmka, Janel K., Chernick, Dustin S., Wattenberg, Elizabeth V., Li, Ling, Arriaga, Edgar A., Distefano, Mark D.
Publicado 2016

Orthogonal Enzyme–Substrate Design Strategy for Discovery of Human Protein Palmitoyltransferase Substrates

por Puthenveetil, Robbins, Auger, Shelby A., Gómez-Navarro, Natalia, Rana, Mitra Shumsher, Das, Riki, Healy, Liam Brendan, Suazo, Kiall F., Shi, Zhen-Dan, Swenson, Rolf E., Distefano, Mark D., Banerjee, Anirban
Publicado 2023

Prenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities

por Petenkova, Anastasiia, Auger, Shelby A., Lamb, Jeffrey, Quellier, Daisy, Carter, Cody, To, On Tak, Milosevic, Jelena, Barghout, Rana, Kugadas, Abirami, Lu, Xiaoxiao, Geddes-McAlister, Jennifer, Fichorova, Raina, Sykes, David B., Distefano, Mark D., Gadjeva, Mihaela
Publicado 2023

Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting

por Wang, Qiang-Qiang, Sun, Ming, Tang, Tao, Lai, De-Hua, Liu, Jing, Maity, Sanjay, He, Kai, Wu, Xi-Ting, Yang, Jiong, Li, Yue-Bao, Tang, Xiao-Yan, Ding, Hui-Yong, Hide, Geoff, Distefano, Mark, Lun, Zhao-Rong, Zhu, Xing-Quan, Long, Shaojun
Publicado 2023