Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding

por Dixon-Clarke, Sarah E., Elkins, Jonathan M., Cheng, S.-W. Grace, Morin, Gregg B., Bullock, Alex N.
Publicado 2015

Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16

por Dixon-Clarke, Sarah E., Shehata, Saifeldin N., Krojer, Tobias, Sharpe, Timothy D., vonDelft, Frank, Sakamoto, Kei, Bullock, Alex N.
Publicado 2017

Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family

por Nonga, Olivier E., Lavogina, Darja, Enkvist, Erki, Kestav, Katrin, Chaikuad, Apirat, Dixon-Clarke, Sarah E., Bullock, Alex N., Kopanchuk, Sergei, Ivan, Taavi, Ekambaram, Ramesh, Viht, Kaido, Knapp, Stefan, Uri, Asko
Publicado 2021

DIPG-20. DELINEATING MEDIATORS OF ONCOGENESIS IN FOXR2-EXPRESSING DIFFUSE MIDLINE GLIOMAS

por Tsai, Jessica, Cejas, Paloma, Coppola, Marissa, Wang, Dayle, Patel, Smruti, Wu, David, Arounleut, Phonepasong, Wei, Xin, Zhou, Ningxuan, Syamala, Sudeepa, Dubois, Frank, Pelton, Kristine, Vogelzang, Jayne, Sousa, Cecilia, Baguette, Audrey, Chen, Xiaolong, Condurat, Alexandra, Dixon-Clarke, Sarah, Zhou, Kevin, Lu, Sophie, Gonzalez, Elizabeth, Chacon, Madison, Digiacomo, Jeromy, Kumbhani, Rushil, Novikov, Dana, Tsoli, Maria, Ziegler, David, Dirksen, Uta, Jager, Natalie, Balsubramanian, Gnana Prakash, Kramm, Christof, Nathrath, Michaela, Bielack, Stefan, Baker, Suzanne, Zhang, Jinghui, McFarland, James, Getz, Gad, Aguet, Francois, Jabado, Nada, Witt, Olaf, Pfister, Stefan, Ligon, Keith, Hovestadt, Volker, Kleinman, Claudia, Long, Henry, Jones, David, Bandopadhayay, Pratiti, Phoenix, Timothy
Publicado 2023

DIPG-19. FOXR2 is an oncogenic driver across pediatric and adult cancers

por Tsai, Jessica W, Cejas, Paloma, Wang, Dayle K, Patel, Smruti, Wu, David W, Arounleut, Phonepasong, Wei, Xin, Zhou, Ningxuan, Syamala, Sudeepa, Dubois, Frank P B, Crane, Alexander, Pelton, Kristine, Vogelzang, Jayne, Sousa, Cecilia, Baguette, Audrey, Chen, Xiaolong, Condurat, Alexandra L, Dixon-Clarke, Sarah E, Zhou, Kevin N, Lu, Sophie D, Gonzalez, Elizabeth M, Chacon, Madison S, Digiacomo, Jeromy J, Kumbhani, Rushil, Novikov, Dana, Hunter, J'Ya, Tsoli, Maria, Ziegler, David S, Dirksen, Uta, Jager, Natalie, Balasubramanian, Gnana Prakash, Kramm, Christof M, Nathrath, Michaela, Bielack, Stefan, Baker, Suzanne J, Zhang, Jinghui, McFarland, James M, Getz, Gad, Aguet, Francois, Jabado, Nada, Witt, Olaf, Pfister, Stefan M, Ligon, Keith L, Kleinman, Claudia L, Long, Henry, Jones, David T W, Bandopadhayay, Pratiti, Phoenix, Timothy N
Publicado 2022

FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits

por Tsai, Jessica W., Cejas, Paloma, Wang, Dayle K., Patel, Smruti, Wu, David W., Arounleut, Phonepasong, Wei, Xin, Zhou, Ningxuan, Syamala, Sudeepa, Dubois, Frank P.B., Crane, Alexander, Pelton, Kristine, Vogelzang, Jayne, Sousa, Cecilia, Baguette, Audrey, Chen, Xiaolong, Condurat, Alexandra L., Dixon-Clarke, Sarah E., Zhou, Kevin N., Lu, Sophie D., Gonzalez, Elizabeth M., Chacon, Madison S., Digiacomo, Jeromy J., Kumbhani, Rushil, Novikov, Dana, Hunter, J'Ya, Tsoli, Maria, Ziegler, David S., Dirksen, Uta, Jager, Natalie, Balasubramanian, Gnana Prakash, Kramm, Christof M., Nathrath, Michaela, Bielack, Stefan, Baker, Suzanne J., Zhang, Jinghui, McFarland, James M., Getz, Gad, Aguet, François, Jabado, Nada, Witt, Olaf, Pfister, Stefan M., Ligon, Keith L., Hovestadt, Volker, Kleinman, Claudia L., Long, Henry, Jones, David T.W., Bandopadhayay, Pratiti, Phoenix, Timothy N.
Publicado 2022