Role of Phospholipases in Fungal Fitness, Pathogenicity, and Drug Development – Lessons from Cryptococcus Neoformans

por Djordjevic, Julianne Teresa
Publicado 2010

Why is a functional PHO pathway required by fungal pathogens to disseminate within a phosphate-rich host: A paradox explained by alkaline pH-simulated nutrient deprivation and expa...

por Lev, Sophie, Djordjevic, Julianne Teresa
Publicado 2018

Inositol polyphosphate–protein interactions: Implications for microbial pathogenicity

por Lev, Sophie, Bowring, Bethany, Desmarini, Desmarini, Djordjevic, Julianne Teresa
Publicado 2021

The Crz1/Sp1 Transcription Factor of Cryptococcus neoformans Is Activated by Calcineurin and Regulates Cell Wall Integrity

por Lev, Sophie, Desmarini, Desmarini, Chayakulkeeree, Methee, Sorrell, Tania C., Djordjevic, Julianne T.
Publicado 2012

Identification of a major IP(5) kinase in Cryptococcus neoformans confirms that PP-IP(5)/IP(7), not IP(6), is essential for virulence

por Li, Cecilia, Lev, Sophie, Saiardi, Adolfo, Desmarini, Desmarini, Sorrell, Tania C., Djordjevic, Julianne T.
Publicado 2016

Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery

por Li, Cecilia, Lev, Sophie, Saiardi, Adolfo, Desmarini, Desmarini, Sorrell, Tania C., Djordjevic, Julianne T.
Publicado 2016

Fungal Kinases With a Sweet Tooth: Pleiotropic Roles of Their Phosphorylated Inositol Sugar Products in the Pathogenicity of Cryptococcus neoformans Present Novel Drug Targeting Op...

por Lev, Sophie, Li, Cecilia, Desmarini, Desmarini, Sorrell, Tania C., Saiardi, Adolfo, Djordjevic, Julianne T.
Publicado 2019

Cryptococcal Phospholipase B1 Is Required for Intracellular Proliferation and Control of Titan Cell Morphology during Macrophage Infection

por Evans, Robert J., Li, Zhongming, Hughes, William S., Djordjevic, Julianne T., Nielsen, Kirsten, May, Robin C.
Publicado 2015

Monitoring Glycolysis and Respiration Highlights Metabolic Inflexibility of Cryptococcus neoformans

por Lev, Sophie, Li, Cecilia, Desmarini, Desmarini, Liuwantara, David, Sorrell, Tania C., Hawthorne, Wayne J., Djordjevic, Julianne T.
Publicado 2020

Rapid Microscopy and Use of Vital Dyes: Potential to Determine Viability of Cryptococcus neoformans in the Clinical Laboratory

por McMullan, Brendan J., Desmarini, Desmarini, Djordjevic, Julianne T., Chen, Sharon C-A., Roper, Michael, Sorrell, Tania C.
Publicado 2015

The PHO signaling pathway directs lipid remodeling in Cryptococcus neoformans via DGTS synthase to recycle phosphate during phosphate deficiency

por Lev, Sophie, Rupasinghe, Thusitha, Desmarini, Desmarini, Kaufman-Francis, Keren, Sorrell, Tania Christine, Roessner, Ute, Djordjevic, Julianne Teresa
Publicado 2019

Fungal Inositol Pyrophosphate IP(7) Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity

por Lev, Sophie, Li, Cecilia, Desmarini, Desmarini, Saiardi, Adolfo, Fewings, Nicole L., Schibeci, Stephen D., Sharma, Raghwa, Sorrell, Tania C., Djordjevic, Julianne T.
Publicado 2015

Koala cathelicidin PhciCath5 has antimicrobial activity, including against Chlamydia pecorum

por Peel, Emma, Cheng, Yuanyuan, Djordjevic, Julianne T., O’Meally, Denis, Thomas, Mark, Kuhn, Michael, Sorrell, Tania C., Huston, Wilhelmina M., Belov, Katherine
Publicado 2021

Identification of Aph1, a Phosphate-Regulated, Secreted, and Vacuolar Acid Phosphatase in Cryptococcus neoformans

por Lev, Sophie, Crossett, Ben, Cha, So Young, Desmarini, Desmarini, Li, Cecilia, Chayakulkeeree, Methee, Wilson, Christabel F., Williamson, P. R., Sorrell, Tania C., Djordjevic, Julianne T.
Publicado 2014

RTA1 Is Involved in Resistance to 7-Aminocholesterol and Secretion of Fungal Proteins in Cryptococcus neoformans

por Smith-Peavler, Emily S., Patel, Ronakkumar, Onumajuru, Adejumoke Mary, Bowring, Bethany G., Miller, Joyce L., Brunel, Jean Michel, Djordjevic, Julianne T., Prabu, Moses M., McClelland, Erin E.
Publicado 2022

Dysregulating PHO Signaling via the CDK Machinery Differentially Impacts Energy Metabolism, Calcineurin Signaling, and Virulence in Cryptococcus neoformans

por Bowring, Bethany Grace, Sethiya, Pooja, Desmarini, Desmarini, Lev, Sophie, Tran Le, Lisa, Bahn, Yong-Sun, Lee, Seung-Heon, Toh-e, Akio, Proschogo, Nicholas, Savage, Tom, Djordjevic, Julianne Teresa
Publicado 2023

Calcium Binding Protein Ncs1 Is Calcineurin Regulated in Cryptococcus neoformans and Essential for Cell Division and Virulence

por Squizani, Eamim Daidrê, Reuwsaat, Júlia Catarina Vieira, Lev, Sophie, Motta, Heryk, Sperotto, Julia, Kaufman-Francis, Keren, Desmarini, Desmarini, Vainstein, Marilene Henning, Staats, Charley Christian, Djordjevic, Julianne T., Kmetzsch, Lívia
Publicado 2020

IP(7)-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery

por Desmarini, Desmarini, Lev, Sophie, Furkert, David, Crossett, Ben, Saiardi, Adolfo, Kaufman-Francis, Keren, Li, Cecilia, Sorrell, Tania C., Wilkinson-White, Lorna, Matthews, Jacqueline, Fiedler, Dorothea, Djordjevic, Julianne Teresa
Publicado 2020

TNP Analogues Inhibit the Virulence Promoting IP(3-4) Kinase Arg1 in the Fungal Pathogen Cryptococcus neoformans

por Desmarini, Desmarini, Truong, Daniel, Wilkinson-White, Lorna, Desphande, Chandrika, Torrado, Mario, Mackay, Joel P., Matthews, Jacqueline M., Sorrell, Tania C., Lev, Sophie, Thompson, Philip E., Djordjevic, Julianne Teresa
Publicado 2022

Pho4 Is Essential for Dissemination of Cryptococcus neoformans to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH

por Lev, Sophie, Kaufman-Francis, Keren, Desmarini, Desmarini, Juillard, Pierre G., Li, Cecilia, Stifter, Sebastian A., Feng, Carl G., Sorrell, Tania C., Grau, Georges E. R., Bahn, Yong-Sun, Djordjevic, Julianne T.
Publicado 2017