A phase 2, randomized, double‐blind, placebo‐controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in pediatric patients with Dravet syndrome or...

por Hahn, Cecil D., Jiang, Yuwu, Villanueva, Vicente, Zolnowska, Marta, Arkilo, Dimitrios, Hsiao, Samuel, Asgharnejad, Mahnaz, Dlugos, Dennis
Publicado 2022

Proposal for an updated seizure classification framework in clinical trials

por Steriade, Claude, Sperling, Michael R., DiVentura, Bree, Lozano, Meryl, Shellhaas, Renée A., Kessler, Sudha Kilaru, Dlugos, Dennis, French, Jacqueline
Publicado 2022

Use of second doses of Valtoco® (diazepam nasal spray) across 24 hours after the initial dose for out‐of‐hospital seizure clusters: Results from a phase 3, open‐label, repeat‐dose...

por Sperling, Michael R., Wheless, James W., Hogan, R. Edward, Dlugos, Dennis, Cascino, Gregory D., Liow, Kore, Rabinowicz, Adrian L., Carrazana, Enrique
Publicado 2022

Assessing the similarity of surface linguistic features related to epilepsy across pediatric hospitals

por Connolly, Brian, Matykiewicz, Pawel, Bretonnel Cohen, K, Standridge, Shannon M, Glauser, Tracy A, Dlugos, Dennis J, Koh, Susan, Tham, Eric, Pestian, John
Publicado 2014

Capturing seizures in clinical trials of antiseizure medications for KCNQ2‐DEE

por Millichap, John J., Harden, Cynthia L., Dlugos, Dennis J., French, Jacqueline A., Butterfield, Noam N., Grayson, Celene, Aycardi, Ernesto, Pimstone, Simon N.
Publicado 2021

Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects

por Traynelis, Stephen F., Dlugos, Dennis, Henshall, David, Mefford, Heather C., Rogawski, Michael A., Staley, Kevin J., Dacks, Penny A., Whittemore, Vicky, Poduri, Annapurna
Publicado 2020

Pharmacokinetics and Tolerability of Multiple Doses of Pharmaceutical-Grade Synthetic Cannabidiol in Pediatric Patients with Treatment-Resistant Epilepsy

por Wheless, James W., Dlugos, Dennis, Miller, Ian, Oh, D. Alexander, Parikh, Neha, Phillips, Steven, Renfroe, J. Ben, Roberts, Colin M., Saeed, Isra, Sparagana, Steven P., Yu, Jin, Cilio, Maria Roberta
Publicado 2019

Considerations for determining the efficacy of new antiseizure medications in children age 1 month to younger than 2 years

por French, Jacqueline A., Cleary, Elena, Dlugos, Dennis, Farfel, Gail, Farrell, Kathleen, Gidal, Barry, Grzeskowiak, Caitlin L., Gurrell, Rachel, Harden, Cynthia, Stalvey, Tracy J., Tsai, Julia, Wirrell, Elaine C., Blum, David, Fountain, Nathan
Publicado 2022

Everolimus for treatment-refractory seizures in TSC: Extension of a randomized controlled trial

por Franz, David N., Lawson, John A., Yapici, Zuhal, Ikeda, Hiroko, Polster, Tilman, Nabbout, Rima, Curatolo, Paolo, de Vries, Petrus J., Dlugos, Dennis J., Voi, Maurizio, Fan, Jenna, Vaury, Alexandra, Pelov, Diana, French, Jacqueline A.
Publicado 2018

Consistent safety and tolerability of Valtoco(®) (diazepam nasal spray) in relationship to usage frequency in patients with seizure clusters: Interim results from a phase 3, long‐t...

por Miller, Ian, Wheless, James W., Hogan, Robert E., Dlugos, Dennis, Biton, Victor, Cascino, Gregory D., Sperling, Michael R., Liow, Kore, Vazquez, Blanca, Segal, Eric B., Tarquinio, Daniel, Mauney, Weldon, Desai, Jay, Rabinowicz, Adrian L., Carrazana, Enrique
Publicado 2021

Final results from a Phase 3, long‐term, open‐label, repeat‐dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy

por Wheless, James W., Miller, Ian, Hogan, R. Edward, Dlugos, Dennis, Biton, Victor, Cascino, Gregory D., Sperling, Michael R., Liow, Kore, Vazquez, Blanca, Segal, Eric B., Tarquinio, Daniel, Mauney, Weldon, Desai, Jay, Rabinowicz, Adrian L., Carrazana, Enrique
Publicado 2021

Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long‐term, open‐label saf...

por Segal, Eric B., Tarquinio, Daniel, Miller, Ian, Wheless, James W., Dlugos, Dennis, Biton, Victor, Cascino, Gregory D., Desai, Jay, Hogan, R. Edward, Liow, Kore, Sperling, Michael R., Vazquez, Blanca, Cook, David F., Rabinowicz, Adrian L., Carrazana, Enrique
Publicado 2021

Genetic Variation in PADI6-PADI4 on 1p36.13 Is Associated with Common Forms of Human Generalized Epilepsy

por Buono, Russell J., Bradfield, Jonathan P., Wei, Zhi, Sperling, Michael R., Dlugos, Dennis J., Privitera, Michael D., French, Jacqueline A., Lo, Warren, Cossette, Patrick, Schachter, Steven C., Basehore, Heather, Lohoff, Falk W., Grant, Struan F. A., Ferraro, Thomas N., Hakonarson, Hakon
Publicado 2021

Focal epilepsy features in a child with Congenital Zika Syndrome

por Jayatilake, Piumi, Oyegunle, Vivian, Waechter, Randall, Landon, Barbara, Fernandes, Michelle, Cudjoe, Nikita, Evans, Roberta, Noël, Trevor, Macpherson, Calum, Donald, Tyhiesia, Abdelbaki, Samah G., Mandalaneni, Kesava, Dlugos, Dennis, Chari, Geetha, Patel, Archana A., Grossi-Soyster, Elysse N., Desiree LaBeaud, A., Blackmon, Karen
Publicado 2020

Epilepsy surveillance in normocephalic children with and without prenatal Zika virus exposure

por Blackmon, Karen, Waechter, Randall, Landon, Barbara, Noël, Trevor, Macpherson, Calum, Donald, Tyhiesia, Cudjoe, Nikita, Evans, Roberta, Burgen, Kemi S., Jayatilake, Piumi, Oyegunle, Vivian, Pedraza, Otto, Abdel Baki, Samah, Thesen, Thomas, Dlugos, Dennis, Chari, Geetha, Patel, Archana A., Grossi-Soyster, Elysse N., Krystosik, Amy R., LaBeaud, A. Desiree
Publicado 2020

Detection of generalized tonic–clonic seizures using surface electromyographic monitoring

por Halford, Jonathan J., Sperling, Michael R., Nair, Dileep R., Dlugos, Dennis J., Tatum, William O., Harvey, Jay, French, Jacqueline A., Pollard, John R., Faught, Edward, Noe, Katherine H., Henry, Thomas R., Jetter, Gina M., Lie, Octavian V., Morgan, Lola C., Girouard, Michael R., Cardenas, Damon P., Whitmire, Luke E., Cavazos, Jose E.
Publicado 2017

Management of Infantile Spasms During the COVID-19 Pandemic

por Grinspan, Zachary M., Mytinger, John R., Baumer, Fiona M., Ciliberto, Michael A., Cohen, Bruce H., Dlugos, Dennis J., Harini, Chellamani, Hussain, Shaun A., Joshi, Sucheta M., Keator, Cynthia G., Knupp, Kelly G., McGoldrick, Patricia E., Nickels, Katherine C., Park, Jun T., Pasupuleti, Archana, Patel, Anup D., Shahid, Asim M., Shellhaas, Renee A., Shrey, Daniel W., Singh, Rani K., Wolf, Steven M., Yozawitz, Elissa G., Yuskaitis, Christopher J., Waugh, Jeff L., Pearl, Phillip L.
Publicado 2020

DNM1 encephalopathy: A new disease of vesicle fission

por von Spiczak, Sarah, Helbig, Katherine L., Shinde, Deepali N., Huether, Robert, Pendziwiat, Manuela, Lourenço, Charles, Nunes, Mark E., Sarco, Dean P., Kaplan, Richard A., Dlugos, Dennis J., Kirsch, Heidi, Slavotinek, Anne, Cilio, Maria R., Cervenka, Mackenzie C., Cohen, Julie S., McClellan, Rebecca, Fatemi, Ali, Yuen, Amy, Sagawa, Yoshimi, Littlejohn, Rebecca, McLean, Scott D., Hernandez-Hernandez, Laura, Maher, Bridget, Møller, Rikke S., Palmer, Elizabeth, Lawson, John A., Campbell, Colleen A., Joshi, Charuta N., Kolbe, Diana L., Hollingsworth, Georgie, Neubauer, Bernd A., Muhle, Hiltrud, Stephani, Ulrich, Scheffer, Ingrid E., Pena, Sérgio D.J., Sisodiya, Sanjay M., Helbig, Ingo
Publicado 2017

Copy number variant analysis from exome data in 349 patients with epileptic encephalopathy

por Allen, Andrew S., Berkovic, Samuel F., Coe, Bradley P., Cook, Joseph, Cossette, Patrick, Delanty, Norman, Dlugos, Dennis, Eichler, Evan E., Epstein, Michael P., Glauser, Tracy, Goldstein, David B., Heinzen, Erin L., Johnson, Michael R., Krumm, Nik, Kuzniecky, Ruben, Lowenstein, Daniel H., Marson, Anthony G., Mefford, Heather C., Nelson, Ben, Esmaeeli Nieh, Sahar, O'Brien, Terence J., Ottman, Ruth, Petrou, Stephen, Petrovski, Slavé, Poduri, Annapurna, Raja, Archana, Ruzzo, Elizabeth K., Scheffer, Ingrid E., Sherr, Elliott, Abou‐Khalil, Bassel, Alldredge, Brian K., Andermann, Eva, Andermann, Frederick, Amron, Dina, Bautista, Jocelyn F., Berkovic, Samuel F., Boro, Alex, Cascino, Gregory, Consalvo, Damian, Crumrine, Patricia, Devinsky, Orrin, Dlugos, Dennis, Epstein, Michael P., Fiol, Miguel, Fountain, Nathan B., French, Jacqueline, Friedman, Daniel, Geller, Eric B., Glauser, Tracy, Glynn, Simon, Haut, Sheryl R., Hayward, Jean, Helmers, Sandra L., Joshi, Sucheta, Kanner, Andres, Kirsch, Heidi E., Knowlton, Robert C., Kossoff, Eric H., Kuperman, Rachel, Kuzniecky, Ruben, Lowenstein, Daniel H., McGuire, Shannon M., Motika, Paul V., Novotny, Edward J., Ottman, Ruth, Paolicchi, Juliann M., Parent, Jack, Park, Kristen, Poduri, Annapurna, Scheffer, Ingrid E., Shellhaas, Renée A., Sherr, Elliott, Shih, Jerry J., Singh, Rani, Sirven, Joseph, Smith, Michael C., Sullivan, Joe, Thio, Liu Lin, Venkat, Anu, Vining, Eileen P.G., Von Allmen, Gretchen K., Weisenberg, Judith L., Widdess‐Walsh, Peter, Winawer, Melodie R.
Publicado 2015

Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy

por Lemke, Johannes R., Geider, Kirsten, Helbig, Katherine L., Heyne, Henrike O., Schütz, Hannah, Hentschel, Julia, Courage, Carolina, Depienne, Christel, Nava, Caroline, Heron, Delphine, Møller, Rikke S., Hjalgrim, Helle, Lal, Dennis, Neubauer, Bernd A., Nürnberg, Peter, Thiele, Holger, Kurlemann, Gerhard, Arnold, Georgianne L., Bhambhani, Vikas, Bartholdi, Deborah, Pedurupillay, Christeen Ramane J., Misceo, Doriana, Frengen, Eirik, Strømme, Petter, Dlugos, Dennis J., Doherty, Emily S., Bijlsma, Emilia K., Ruivenkamp, Claudia A., Hoffer, Mariette J.V., Goldstein, Amy, Rajan, Deepa S., Narayanan, Vinodh, Ramsey, Keri, Belnap, Newell, Schrauwen, Isabelle, Richholt, Ryan, Koeleman, Bobby P.C., Sá, Joaquim, Mendonça, Carla, de Kovel, Carolien G.F., Weckhuysen, Sarah, Hardies, Katia, De Jonghe, Peter, De Meirleir, Linda, Milh, Mathieu, Badens, Catherine, Lebrun, Marine, Busa, Tiffany, Francannet, Christine, Piton, Amélie, Riesch, Erik, Biskup, Saskia, Vogt, Heinrich, Dorn, Thomas, Helbig, Ingo, Michaud, Jacques L., Laube, Bodo, Syrbe, Steffen
Publicado 2016