Exome sequencing and complex disease: practical aspects of rare variant association studies

por Do, Ron, Kathiresan, Sekar, Abecasis, Gonçalo R.
Publicado 2012

HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases

por Jordan, Daniel M., Verbanck, Marie, Do, Ron
Publicado 2019

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

por Verbanck, Marie, Chen, Chia-Yen, Neale, Benjamin, Do, Ron
Publicado 2018

Probing the aggregated effects of purifying selection per individual on 1,380 medical phenotypes in the UK Biobank

por Vy, Ha My T., Jordan, Daniel M., Balick, Daniel J., Do, Ron
Publicado 2021

No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans

por Do, Ron, Balick, Daniel, Li, Heng, Adzhubei, Ivan, Sunyaev, Shamil, Reich, David
Publicado 2015

Machine Learning Enables Single-Score Assessment of MASLD Presence and Severity

por Chen, Robert, Petrazzini, Ben Omega, Nadkarni, Girish, Rocheleau, Ghislain, Bansal, Meena, Do, Ron
Publicado 2023

Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck

por Balick, Daniel J., Do, Ron, Cassa, Christopher A., Reich, David, Sunyaev, Shamil R.
Publicado 2015

Non-invasive ventilation versus mechanical ventilation in hypoxemic patients with COVID-19

por Forrest, Iain S., Jaladanki, Suraj K., Paranjpe, Ishan, Glicksberg, Benjamin S., Nadkarni, Girish N., Do, Ron
Publicado 2021

An atlas of associations between 14 micronutrients and 22 cancer outcomes: Mendelian randomization analyses

por Kim, Jong Yeob, Song, Minku, Kim, Min Seo, Natarajan, Pradeep, Do, Ron, Myung, Woojae, Won, Hong-Hee
Publicado 2023

Prioritization of therapeutic targets for dyslipidemia using integrative multi-omics and multi-trait analysis

por Kim, Min Seo, Song, Minku, Kim, Beomsu, Shim, Injeong, Kim, Dan Say, Natarajan, Pradeep, Do, Ron, Won, Hong-Hee
Publicado 2023

Disproportionate Contributions of Select Genomic Compartments and Cell Types to Genetic Risk for Coronary Artery Disease

por Won, Hong-Hee, Natarajan, Pradeep, Dobbyn, Amanda, Jordan, Daniel M., Roussos, Panos, Lage, Kasper, Raychaudhuri, Soumya, Stahl, Eli, Do, Ron
Publicado 2015

No causal effects of serum urate levels on the risk of chronic kidney disease: A Mendelian randomization study

por Jordan, Daniel M., Choi, Hyon K., Verbanck, Marie, Topless, Ruth, Won, Hong-Hee, Nadkarni, Girish, Merriman, Tony R., Do, Ron
Publicado 2019

A tissue-level phenome-wide network map of colocalized genes and phenotypes in the UK Biobank

por Rocheleau, Ghislain, Forrest, Iain S., Duffy, Áine, Bafna, Shantanu, Dobbyn, Amanda, Verbanck, Marie, Won, Hong-Hee, Jordan, Daniel M., Do, Ron
Publicado 2022

Intraocular Pressure, Glaucoma, and Dietary Caffeine Consumption: A Gene—Diet Interaction Study from the UK Biobank

por Kim, Jihye, Aschard, Hugues, Kang, Jae H., Lentjes, Marleen A.H., Do, Ron, Wiggs, Janey L., Khawaja, Anthony P., Pasquale, Louis R.
Publicado 2020

Machine Learning Identifies Plasma Metabolites Associated With Heart Failure in Underrepresented Populations With the TTR V122I Variant

por Park, Joshua K., Petrazzini, Ben O., Saha, Aparna, Vaid, Akhil, Vy, Ha My T., Márquez‐Luna, Carla, Chan, Lili, Nadkarni, Girish N., Do, Ron
Publicado 2023

Statin Use in Relation to Intraocular Pressure, Glaucoma, and Ocular Coherence Tomography Parameters in the UK Biobank

por Kim, Jihye, Kennedy Neary, Marianne T., Aschard, Hugues, Palakkamanil, Mathew M., Do, Ron, Wiggs, Janey L., Khawaja, Anthony P., Pasquale, Louis R., Kang, Jae H.
Publicado 2022

Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study

por Bailey, Swneke D., Xie, Changchun, Do, Ron, Montpetit, Alexandre, Diaz, Rafael, Mohan, Viswanathan, Keavney, Bernard, Yusuf, Salim, Gerstein, Hertzel C., Engert, James C., Anand, Sonia
Publicado 2010

A Genotype-First Approach to Exploring Mendelian Cardiovascular Traits with Clear External Manifestations

por Wenger, Brittany M., Patel, Nihir, Lui, Madeline, Moscati, Arden, Do, Ron, Stewart, Douglas R., Tartaglia, Marco, Muiño-Mosquera, Laura, De Backer, Julie, Kontorovich, Amy R., Gelb, Bruce D.
Publicado 2020

Cannabis Use and CKD: Epidemiological Associations and Mendelian Randomization

por Dellepiane, Sergio, Paranjpe, Ishan, Rajagopal, Madhumitha, Kamat, Samir, O’Hagan, Ross, Gulamali, Faris, Rein, Joshua L., Charney, Alexander W., Do, Ron, Coca, Steven, Glicksberg, Benjamin S., Nadkarni, Girish N.
Publicado 2022

A machine learning model identifies patients in need of autoimmune disease testing using electronic health records

por Forrest, Iain S., Petrazzini, Ben O., Duffy, Áine, Park, Joshua K., O’Neal, Anya J., Jordan, Daniel M., Rocheleau, Ghislain, Nadkarni, Girish N., Cho, Judy H., Blazer, Ashira D., Do, Ron
Publicado 2023