Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1

por Manolaridis, Ioannis, Kulkarni, Kiran, Dodd, Roger B., Ogasawara, Satoshi, Zhang, Ziguo, Bineva, Ganka, Reilly, Nicola O’, Hanrahan, Sarah J., Thompson, Andrew J., Cronin, Nora, Iwata, So, Barford, David
Publicado 2013

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions

por Burr, Stephen P., Costa, Ana S.H., Grice, Guinevere L., Timms, Richard T., Lobb, Ian T., Freisinger, Peter, Dodd, Roger B., Dougan, Gordon, Lehner, Paul J., Frezza, Christian, Nathan, James A.
Publicado 2016

A simeprevir-inducible molecular switch for the control of cell and gene therapies

por Chin, Stacey E., Schindler, Christina, Vinall, Lisa, Dodd, Roger B., Bamber, Lisa, Legg, Sandrine, Sigurdardottir, Anna, Rees, D. Gareth, Malcolm, Tim I. M., Spratley, Samantha J., Granéli, Cecilia, Sumner, Jonathan, Tigue, Natalie J.
Publicado 2023

TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant

por Thornton, Peter, Sevalle, Jean, Deery, Michael J, Fraser, Graham, Zhou, Ye, Ståhl, Sara, Franssen, Elske H, Dodd, Roger B, Qamar, Seema, Gomez Perez‐Nievas, Beatriz, Nicol, Louise SC, Eketjäll, Susanna, Revell, Jefferson, Jones, Clare, Billinton, Andrew, St George‐Hyslop, Peter H, Chessell, Iain, Crowther, Damian C
Publicado 2017

Structural Interactions between Inhibitor and Substrate Docking Sites Give Insight into Mechanisms of Human PS1 Complexes

por Li, Yi, Lu, Stephen Hsueh-Jeng, Tsai, Ching-Ju, Bohm, Christopher, Qamar, Seema, Dodd, Roger B., Meadows, William, Jeon, Amy, McLeod, Adam, Chen, Fusheng, Arimon, Muriel, Berezovska, Oksana, Hyman, Bradley T., Tomita, Taisuke, Iwatsubo, Takeshi, Johnson, Christopher M., Farrer, Lindsay A., Schmitt-Ulms, Gerold, Fraser, Paul E., St George-Hyslop, Peter H.
Publicado 2014

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation

por Vilalta, Anna, Zhou, Ye, Sevalle, Jean, Griffin, Jennifer K., Satoh, Kanayo, Allendorf, David H., De, Suman, Puigdellívol, Mar, Bruzas, Arturas, Burguillos, Miguel A., Dodd, Roger B., Chen, Fusheng, Zhang, Yalun, Flagmeier, Patrick, Needham, Lisa-Maria, Enomoto, Masahiro, Qamar, Seema, Henderson, James, Walter, Jochen, Fraser, Paul E., Klenerman, David, Lee, Steven F., St George-Hyslop, Peter, Brown, Guy C.
Publicado 2021

Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex

por Strickson, Sam, Houslay, Kirsty F., Negri, Victor A., Ohne, Yoichiro, Ottosson, Tomas, Dodd, Roger B., Huntington, Catherine Chaillan, Baker, Tina, Li, Jingjing, Stephenson, Katherine E., O'Connor, Andy J., Sagawe, J. Sophie, Killick, Helen, Moore, Tom, Rees, D. Gareth, Koch, Sofia, Sanden, Caroline, Wang, Yixin, Gubbins, Elise, Ghaedi, Mahboobe, Kolbeck, Roland, Saumyaa, Saumyaa, Erjefält, Jonas S., Sims, Gary P., Humbles, Alison A., Scott, Ian C., Romero Ros, Xavier, Cohen, E. Suzanne
Publicado 2023

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

por Murakami, Tetsuro, Qamar, Seema, Lin, Julie Qiaojin, Schierle, Gabriele S. Kaminski, Rees, Eric, Miyashita, Akinori, Costa, Ana R., Dodd, Roger B., Chan, Fiona T.S., Michel, Claire H., Kronenberg-Versteeg, Deborah, Li, Yi, Yang, Seung-Pil, Wakutani, Yosuke, Meadows, William, Ferry, Rodylyn Rose, Dong, Liang, Tartaglia, Gian Gaetano, Favrin, Giorgio, Lin, Wen-Lang, Dickson, Dennis W., Zhen, Mei, Ron, David, Schmitt-Ulms, Gerold, Fraser, Paul E., Shneider, Neil A., Holt, Christine, Vendruscolo, Michele, Kaminski, Clemens F., St George-Hyslop, Peter
Publicado 2015