Potentiation of Thrombin Generation in Hemophilia A Plasma by Coagulation Factor VIII and Characterization of Antibody-Specific Inhibition

por Doshi, Bhavya S., Gangadharan, Bagirath, Doering, Christopher B., Meeks, Shannon L.
Publicado 2012

Generation of an Optimized Lentiviral Vector Encoding a High-Expression Factor VIII Transgene for Gene Therapy of Hemophilia A

por Johnston, Jennifer M., Denning, Gabriela, Doering, Christopher B., Spencer, H. Trent
Publicado 2012

The Immune Response to the fVIII Gene Therapy in Preclinical Models

por Patel, Seema R., Lundgren, Taran S., Spencer, H. Trent, Doering, Christopher B.
Publicado 2020

Pharmacokinetic analysis identifies a factor VIII immunogenicity threshold after AAV gene therapy in hemophilia A mice

por Lundgren, Taran S., Denning, Gabriela, Stowell, Sean R., Spencer, H. Trent, Doering, Christopher B.
Publicado 2022

Regulatory Framework for Academic Investigator-Sponsored Investigational New Drug Development of Cell and Gene Therapies in the USA

por Dasgupta, Anindya, Herzegh, Kristen, Spencer, H. Trent, Doering, Christopher, Day, Eric, Swaney, William P.
Publicado 2021

A functional selection reveals previously undetected anti-phage defence systems in the E. coli pangenome

por Vassallo, Christopher N., Doering, Christopher R., Littlehale, Megan L., Teodoro, Gabriella I. C., Laub, Michael T.
Publicado 2022

Development and Characterization of Recombinant Ovine Coagulation Factor VIII

por Zakas, Philip M., Gangadharan, Bagirath, Almeida-Porada, Graca, Porada, Christopher D., Spencer, H. Trent, Doering, Christopher B.
Publicado 2012

Target-Cell-Directed Bioengineering Approaches for Gene Therapy of Hemophilia A

por Brown, Harrison C., Zakas, Philip M., George, Stephan N., Parker, Ernest T., Spencer, H. Trent, Doering, Christopher B.
Publicado 2018

Non-signaling Chimeric Antigen Receptors Enhance Antigen-Directed Killing by γδ T Cells in Contrast to αβ T Cells

por Fleischer, Lauren C., Becker, Scott A., Ryan, Rebecca E., Fedanov, Andrew, Doering, Christopher B., Spencer, H. Trent
Publicado 2020

SAXS analysis of the intrinsic tenase complex bound to a lipid nanodisc highlights intermolecular contacts between factors VIIIa/IXa

por Childers, Kenneth C., Peters, Shaun C., Lollar, Pete, Spencer, Harold Trent, Doering, Christopher B., Spiegel, Paul C.
Publicado 2022

Genetic engineering of chimeric antigen receptors using lamprey derived variable lymphocyte receptors

por Moot, Robert, Raikar, Sunil S, Fleischer, Lauren, Querrey, Melissa, Tylawsky, Daniel E, Nakahara, Hirotomo, Doering, Christopher B, Spencer, H Trent
Publicado 2016

Ex vivo expanded patient-derived γδ T-cell immunotherapy enhances neuroblastoma tumor regression in a murine model

por Zoine, Jaquelyn T., Knight, Kristopher A., Fleischer, Lauren C., Sutton, Kathryn S., Goldsmith, Kelly C., Doering, Christopher B., Spencer, H. Trent
Publicado 2019

Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery

por Brown, Harrison C, Wright, J Fraser, Zhou, Shangzhen, Lytle, Allison M, Shields, Jordan E, Spencer, H Trent, Doering, Christopher B
Publicado 2014

Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction

por Zakas, Philip M., Brown, Harrison C., Knight, Kristopher, Meeks, Shannon L., Spencer, H. Trent, Gaucher, Eric A., Doering, Christopher B.
Publicado 2016

Effects of FVIII immunity on hepatocyte and hematopoietic stem cell–directed gene therapy of murine hemophilia A

por Lytle, Allison M, Brown, Harrison C, Paik, Na Yoon, Knight, Kristopher A, Wright, J Fraser, Spencer, H Trent, Doering, Christopher B
Publicado 2016

Enhancing the effectiveness of γδ T cells by mRNA transfection of chimeric antigen receptors or bispecific T cell engagers

por Becker, Scott A., Petrich, Brian G., Yu, Bing, Knight, Kristopher A., Brown, Harrison C., Raikar, Sunil S., Doering, Christopher B., Spencer, H. Trent
Publicado 2023

Dissecting the cellular components of ex vivo γδ T cell expansions to optimize selection of potent cell therapy donors for neuroblastoma immunotherapy trials

por Jonus, Hunter C., Burnham, Rebecca E., Ho, Andrew, Pilgrim, Adeiye A., Shim, Jenny, Doering, Christopher B., Spencer, H. Trent, Goldsmith, Kelly C.
Publicado 2022

Non-genotoxic conditioning facilitates hematopoietic stem cell gene therapy for hemophilia A using bioengineered factor VIII

por Russell, Athena L., Prince, Chengyu, Lundgren, Taran S., Knight, Kristopher A., Denning, Gabriela, Alexander, Jordan S., Zoine, Jaquelyn T., Spencer, H. Trent, Chandrakasan, Shanmuganathan, Doering, Christopher B.
Publicado 2021

Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor

por Ronayne, Estelle K., Peters, Shaun C., Gish, Joseph S., Wilson, Celena, Spencer, H. Trent, Doering, Christopher B., Lollar, Pete, Spiegel, P. Clint, Childers, Kenneth C.
Publicado 2021

Structure of coagulation factor VIII bound to a patient-derived anti–C1 domain antibody inhibitor

por Childers, Kenneth C., Avery, Nathan G., Estrada Alamo, Kevin A., Davulcu, Omar, Haynes, Rose Marie, Lollar, Pete, Doering, Christopher B., Coxon, Carmen H., Spiegel, P. Clint
Publicado 2023