Hedgehog Signaling and Truncated GLI1 in Cancer

por Doheny, Daniel, Manore, Sara G., Wong, Grace L., Lo, Hui-Wen
Publicado 2020

IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment

por Manore, Sara G., Doheny, Daniel L., Wong, Grace L., Lo, Hui-Wen
Publicado 2022

Editor’s Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis

por Foley, Briana, Doheny, Daniel L., Black, Michael B., Pendse, Salil N., Wetmore, Barbara A., Clewell, Rebecca A., Andersen, Melvin E., Deisenroth, Chad
Publicado 2017

54. tGLI1 IS AN ACTIONABLE THERAPEUTIC TARGET IN BREAST CANCER BRAIN METASTASES

por Doheny, Daniel, Sirkisoon, Sherona, Rimkus, Tadas, Zhu, Dongqin, Aguayo, Noah, Anguelov, Marlyn, Manore, Sara, Regua, Angelina, Thomas, Alexandra, Henson-Masters, Adrianna, Strowd, Roy, Lo, Hui-Wen
Publicado 2020

BSCI-13. TUMOR-SPECIFIC tGLI1 TRANSCRIPTION FACTOR MEDIATES BREAST CANCER BRAIN METASTASIS VIA ACTIVATING METASTASIS-INITIATING CANCER STEM CELLS AND ASTROCYTES IN THE TUMOR MICROE...

por Sirkisoon, Sherona, Carpenter, Richard, Rimkus, Tadas, Doheny, Daniel, Zhu, Dongqin, Aguayo, Noah, Anguelov, Marlyn, Arrigo, Austin, Regua, Angelina, Xing, Fei, Chan, Michael, Metheny-Barlow, Linda, Watabe, Kounosuke, Lo, Hui-Wen
Publicado 2019

BSCI-02. tGLI1 IS A NOVEL, ACTIONABLE TARGET FOR THE TREATMENT OF BREAST CANCER BRAIN METASTASES

por Doheny, Daniel, Sirkisoon, Sherona, Rimkus, Tadas, Zhu, Dongqin, Aguayo, Noah, Harrison, Alexandria, Anguelov, Marlyn, Xing, Fei, Metheny-Barlow, Linda, Watabe, Kounosuke, Thomas, Alexandra, Masters, Adrianna Henson, Strowd, Roy, Lo, Hui-Wen
Publicado 2019

Editor’s Highlight: Development of an In vitro Assay Measuring Uterine-Specific Estrogenic Responses for Use in Chemical Safety Assessment

por Miller, Michelle M., Alyea, Rebecca A., LeSommer, Caroline, Doheny, Daniel L., Rowley, Sean M., Childs, Kristin M., Balbuena, Pergentino, Ross, Susan M., Dong, Jian, Sun, Bin, Andersen, Melvin A., Clewell, Rebecca A.
Publicado 2016

BSCI-14. tGLI1 is an actionable therapeutic target in breast cancer brain metastases

por Doheny, Daniel, Manore, Sara, Wong, Grace, Zhu, Dongqin, Sirkisoon, Sherona, Rimkus, Tadas, Anguelov, Marlyn, Aguayo, Noah, Regua, Angelina, Cox, Anderson O’Brian, Furdui, Cristina, Thomas, Alexandra, Masters, Adrianna Henson, Strowd, Roy, Lo, Hui-Wen
Publicado 2021

An FDA-Approved Antifungal, Ketoconazole, and Its Novel Derivative Suppress tGLI1-Mediated Breast Cancer Brain Metastasis by Inhibiting the DNA-Binding Activity of Brain Metastasis...

por Doheny, Daniel, Manore, Sara, Sirkisoon, Sherona R., Zhu, Dongqin, Aguayo, Noah R., Harrison, Alexandria, Najjar, Mariana, Anguelov, Marlyn, Cox, Anderson O’Brien, Furdui, Cristina M., Watabe, Kounosuke, Hollis, Thomas, Thomas, Alexandra, Strowd, Roy, Lo, Hui-Wen
Publicado 2022

TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment

por Sirkisoon, Sherona R., Carpenter, Richard L., Rimkus, Tadas, Doheny, Daniel, Zhu, Dongqin, Aguayo, Noah R., Xing, Fei, Chan, Michael, Ruiz, Jimmy, Metheny-Barlow, Linda J., Strowd, Roy, Lin, Jiayuh, Pasche, Boris, Debinski, Waldemar, Watabe, Kounosuke, Lo, Hui-Wen
Publicado 2019

Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis

por Doheny, Daniel, Sirkisoon, Sherona, Carpenter, Richard L., Aguayo, Noah Reeve, Regua, Angelina T., Anguelov, Marlyn, Manore, Sara G., Arrigo, Austin, Jalboush, Sara Abu, Wong, Grace L., Yu, Yang, Wagner, Calvin J., Chan, Michael, Ruiz, Jimmy, Thomas, Alexandra, Strowd, Roy, Lin, Jiayuh, Lo, Hui-Wen
Publicado 2020

TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers

por Regua, Angelina T., Aguayo, Noah R., Jalboush, Sara Abu, Doheny, Daniel L., Manore, Sara G., Zhu, Dongqin, Wong, Grace L., Arrigo, Austin, Wagner, Calvin J., Yu, Yang, Thomas, Alexandra, Chan, Michael D., Ruiz, Jimmy, Jin, Guangxu, Strowd, Roy, Sun, Peiqing, Lin, Jiayuh, Lo, Hui-Wen
Publicado 2021