Synthesis and Disinfection Effect of the Pyridine-4-aldoxime Based Salts

por Marek, Jan, Malinak, David, Dolezal, Rafael, Soukup, Ondrej, Pasdiorova, Marketa, Dolezal, Martin, Kuca, Kamil
Publicado 2015

Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study

por Sepsova, Vendula, Karasova, Jana Zdarova, Korabecny, Jan, Dolezal, Rafael, Zemek, Filip, Bennion, Brian J., Kuca, Kamil
Publicado 2013

Classification of Ataxic Gait

por Vyšata, Oldřich, Ťupa, Ondřej, Procházka, Aleš, Doležal, Rafael, Cejnar, Pavel, Bhorkar, Aprajita Milind, Dostál, Ondřej, Vališ, Martin
Publicado 2021

Raman Spectroscopy as a Novel Method for the Characterization of Polydioxanone Medical Stents Biodegradation

por Loskot, Jan, Jezbera, Daniel, Bezrouk, Aleš, Doležal, Rafael, Andrýs, Rudolf, Francová, Vendula, Miškář, Dominik, Myslivcová Fučíková, Alena
Publicado 2021

Concentration of Donepezil in the Cerebrospinal Fluid of AD Patients: Evaluation of Dosage Sufficiency in Standard Treatment Strategy

por Valis, Martin, Masopust, Jiri, Vysata, Oldrich, Hort, Jakub, Dolezal, Rafael, Tomek, Jiri, Misik, Jan, Kuca, Kamil, Karasova, Jana Zdarova
Publicado 2016

Molecular Modeling Studies on the Interactions of Aflatoxin B1 and Its Metabolites with Human Acetylcholinesterase. Part II: Interactions with the Catalytic Anionic Site (CAS)

por de Almeida, Joyce S. F. D., Dolezal, Rafael, Krejcar, Ondrej, Kuca, Kamil, Musilek, Kamil, Jun, Daniel, França, Tanos C. C.
Publicado 2018

Profiling donepezil template into multipotent hybrids with antioxidant properties

por Mezeiova, Eva, Spilovska, Katarina, Nepovimova, Eugenie, Gorecki, Lukas, Soukup, Ondrej, Dolezal, Rafael, Malinak, David, Janockova, Jana, Jun, Daniel, Kuca, Kamil, Korabecny, Jan
Publicado 2018

Rational Design of a New Class of Toll-Like Receptor 4 (TLR4) Tryptamine Related Agonists by Means of the Structure- and Ligand-Based Virtual Screening for Vaccine Adjuvant Discove...

por Honegr, Jan, Dolezal, Rafael, Malinak, David, Benkova, Marketa, Soukup, Ondrej, de Almeida, Joyce S. F. D., Franca, Tanos C. C., Kuca, Kamil, Prymula, Roman
Publicado 2018

Wide-Antimicrobial Spectrum of Picolinium Salts

por Salajkova, Sarka, Benkova, Marketa, Marek, Jan, Sleha, Radek, Prchal, Lukas, Malinak, David, Dolezal, Rafael, Sepčić, Kristina, Gunde-Cimerman, Nina, Kuca, Kamil, Soukup, Ondrej
Publicado 2020

In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier

por Chlebek, Jakub, Korábečný, Jan, Doležal, Rafael, Štěpánková, Šárka, Pérez, Daniel I., Hošťálková, Anna, Opletal, Lubomír, Cahlíková, Lucie, Macáková, Kateřina, Kučera, Tomáš, Hrabinová, Martina, Jun, Daniel
Publicado 2019

Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods

por Janockova, Jana, Dolezal, Rafael, Nepovimova, Eugenie, Kobrlova, Tereza, Benkova, Marketa, Kuca, Kamil, Konecny, Jan, Mezeiova, Eva, Melikova, Michaela, Hepnarova, Vendula, Ring, Avi, Soukup, Ondrej, Korabecny, Jan
Publicado 2018

The pharmacokinetic parameters and the effect of a single and repeated doses of memantine on gastric myoelectric activity in experimental pigs

por Bures, Jan, Kvetina, Jaroslav, Radochova, Vera, Tacheci, Ilja, Peterova, Eva, Herman, David, Dolezal, Rafael, Kopacova, Marcela, Rejchrt, Stanislav, Douda, Tomas, Sestak, Vit, Douda, Ladislav, Karasova, Jana Zdarova
Publicado 2020

Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities

por Chrienova, Zofia, Nepovimova, Eugenie, Andrys, Rudolf, Dolezal, Rafael, Janockova, Jana, Muckova, Lubica, Fabova, Lenka, Soukup, Ondrej, Oleksak, Patrik, Valis, Martin, Korabecny, Jan, Marco-Contelles, José, Kuca, Kamil
Publicado 2022

Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer’s Agents: Design, Synthesis and Biological Evaluation

por Spilovska, Katarina, Korabecny, Jan, Sepsova, Vendula, Jun, Daniel, Hrabinova, Martina, Jost, Petr, Muckova, Lubica, Soukup, Ondrej, Janockova, Jana, Kucera, Tomas, Dolezal, Rafael, Mezeiova, Eva, Kaping, Daniel, Kuca, Kamil
Publicado 2017

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment

por Korabecny, Jan, Andrs, Martin, Nepovimova, Eugenie, Dolezal, Rafael, Babkova, Katerina, Horova, Anna, Malinak, David, Mezeiova, Eva, Gorecki, Lukas, Sepsova, Vendula, Hrabinova, Martina, Soukup, Ondrej, Jun, Daniel, Kuca, Kamil
Publicado 2015

Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

por Malinak, David, Dolezal, Rafael, Hepnarova, Vendula, Hozova, Miroslava, Andrys, Rudolf, Bzonek, Petr, Racakova, Veronika, Korabecny, Jan, Gorecki, Lukas, Mezeiova, Eva, Psotka, Miroslav, Jun, Daniel, Kuca, Kamil, Musilek, Kamil
Publicado 2020

The Effect of Chemical Structure of OEG Ligand Shells with Quaternary Ammonium Moiety on the Colloidal Stabilization, Cellular Uptake and Photothermal Stability of Gold Nanorods

por Salajkova, Sarka, Havel, Filip, Sramek, Michal, Novotny, Filip, Malinak, David, Dolezal, Rafael, Prchal, Lukas, Benkova, Marketa, Soukup, Ondrej, Musilek, Kamil, Kuca, Kamil, Bartek, Jiri, Proska, Jan, Zarska, Monika, Hodny, Zdenek
Publicado 2021

The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric My...

por Bures, Jan, Tacheci, Ilja, Kvetina, Jaroslav, Radochova, Vera, Prchal, Lukas, Kohoutova, Darina, Valis, Martin, Novak, Martin, Dolezal, Rafael, Kopacova, Marcela, Rejchrt, Stanislav, Sestak, Vit, Knoblochova, Veronika, Peterova, Eva, Zdarova Karasova, Jana
Publicado 2021

Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer’s Disease Treatment

por Schmidt, Monika, Benek, Ondrej, Vinklarova, Lucie, Hrabinova, Martina, Zemanova, Lucie, Chribek, Matej, Kralova, Vendula, Hroch, Lukas, Dolezal, Rafael, Lycka, Antonin, Prchal, Lukas, Jun, Daniel, Aitken, Laura, Gunn-Moore, Frank, Kuca, Kamil, Musilek, Kamil
Publicado 2020

Development of 2-Methoxyhuprine as Novel Lead for Alzheimer’s Disease Therapy

por Mezeiova, Eva, Korabecny, Jan, Sepsova, Vendula, Hrabinova, Martina, Jost, Petr, Muckova, Lubica, Kucera, Tomas, Dolezal, Rafael, Misik, Jan, Spilovska, Katarina, Pham, Ngoc Lam, Pokrievkova, Lucia, Roh, Jaroslav, Jun, Daniel, Soukup, Ondrej, Kaping, Daniel, Kuca, Kamil
Publicado 2017