DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells

por Dolman, M. Emmy M., van der Ploeg, Ida, Koster, Jan, Bate-Eya, Laurel Tabe, Versteeg, Rogier, Caron, Huib N., Molenaar, Jan J.
Publicado 2015

Decitabine mildly attenuates MLL‐rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo‐sensitizer

por Schneider, Pauline, Castro, Patricia Garrido, Pinhanços, Sandra M., Kerstjens, Mark, van Roon, Eddy H., Essing, Anke H.W., Dolman, M. Emmy M., Molenaar, Jan J., Pieters, Rob, Stam, Ronald W.
Publicado 2020

High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition

por Bate-Eya, Laurel T., den Hartog, Ilona J.M., van der Ploeg, Ida, Schild, Linda, Koster, Jan, Santo, Evan E., Westerhout, Ellen M., Versteeg, Rogier, Caron, Huib N., Molenaar, Jan J., Dolman, M. Emmy M.
Publicado 2016

High-Throughput Drug Library Screening in Primary KMT2A-Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling

por Wander, Priscilla, Arentsen-Peters, Susan T. C. J. M., Vrenken, Kirsten S., Pinhanҫos, Sandra Mimoso, Koopmans, Bianca, Dolman, M. Emmy M., Jones, Luke, Garrido Castro, Patricia, Schneider, Pauline, Kerstjens, Mark, Molenaar, Jan J., Pieters, Rob, Zwaan, Christian Michel, Stam, Ronald W.
Publicado 2022

The clinical and biological characteristics of NUP98-KDM5A pediatric acute myeloid leukemia

por Noort, Sanne, Wander, Priscilla, Alonzo, Todd A., Smith, Jenny, Ries, Rhonda E., Gerbing, Robert B., Dolman, M. Emmy M., Locatelli, Franco, Reinhardt, Dirk, Baruchel, Andre, Stary, Jan, Molenaar, Jan J., Stam, Ronald W., van den Heuvel-Eibrink, Marry M., Zwaan, C. Michel, Meshinchi, Soheil
Publicado 2020

Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma

por Keller, Kaylee M., Eleveld, Thomas F., Schild, Linda, van den Handel, Kim, van den Boogaard, Marlinde, Amo-Addae, Vicky, Eising, Selma, Ober, Kimberley, Koopmans, Bianca, Looijenga, Leendert, Tytgat, Godelieve A.M., Ylstra, Bauke, Molenaar, Jan J., Dolman, M. Emmy M., van Hooff, Sander R.
Publicado 2022

MEK inhibition causes BIM stabilization and increased sensitivity to BCL-2 family member inhibitors in RAS-MAPK-mutated neuroblastoma

por Eleveld, Thomas F., Vernooij, Lindy, Schild, Linda, Koopmans, Bianca, Alles, Lindy K., Ebus, Marli E., Dandis, Rana, van Tinteren, Harm, Caron, Huib N., Koster, Jan, van Noesel, Max M., Tytgat, Godelieve A. M., Eising, Selma, Versteeg, Rogier, Dolman, M. Emmy M., Molenaar, Jan J.
Publicado 2023

The potential of PARP as a therapeutic target across pediatric solid malignancies

por Keller, Kaylee M., Koetsier, Joost, Schild, Linda, Amo-Addae, Vicky, Eising, Selma, van den Handel, Kim, Ober, Kimberley, Koopmans, Bianca, Essing, Anke, van den Boogaard, Marlinde L., Langenberg, Karin P. S., Jäger, Natalie, Kool, Marcel, Pfister, Stefan, Dolman, M. Emmy M., Molenaar, Jan J., van Hooff, Sander R.
Publicado 2023

Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma

por George, Sally L, Lorenzi, Federica, King, David, Hartlieb, Sabine, Campbell, James, Pemberton, Helen, Toprak, Umut H, Barker, Karen, Tall, Jennifer, da Costa, Barbara Martins, van den Boogaard, Marlinde L, Dolman, M Emmy M, Molenaar, Jan J, Bryant, Helen E, Westermann, Frank, Lord, Christopher J, Chesler, Louis
Publicado 2020

High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia

por Wander, Priscilla, Arentsen-Peters, Susan T.C.J.M., Pinhanҫos, Sandra S., Koopmans, Bianca, Dolman, M.Emmy M., Ariese, Rijndert, Bos, Frank L., Castro, Patricia Garrido, Jones, Luke, Schneider, Pauline, Navarro, Miriam Guillen, Molenaar, Jan J., Rios, Anne C., Zwaan, C. Michel, Stam, Ronald W.
Publicado 2021

Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma

por van den Boogaard, Marlinde L., Oka, Rurika, Hakkert, Anne, Schild, Linda, Ebus, Marli E., van Gerven, Michael R., Zwijnenburg, Danny A., Molenaar, Piet, Hoyng, Lieke L., Dolman, M. Emmy M., Essing, Anke H. W., Koopmans, Bianca, Helleday, Thomas, Drost, Jarno, van Boxtel, Ruben, Versteeg, Rogier, Koster, Jan, Molenaar, Jan J.
Publicado 2021

High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer

por Mayoh, Chelsea, Mao, Jie, Xie, Jinhan, Tax, Gabor, Chow, Shu-Oi, Cadiz, Roxanne, Pazaky, Karina, Barahona, Paulette, Ajuyah, Pamela, Trebilcock, Peter, Malquori, Angela, Gunther, Kate, Avila, Anica, Yun, Doo Young, Alfred, Stephanie, Gopalakrishnan, Anjana, Kamili, Alvin, Wong, Marie, Cowley, Mark J., Jessop, Sophie, Lau, Loretta M.S., Trahair, Toby N., Ziegler, David S., Fletcher, Jamie I., Gifford, Andrew J., Tsoli, Maria, Marshall, Glenn M., Haber, Michelle, Tyrrell, Vanessa, Failes, Timothy W., Arndt, Greg M., Lock, Richard B., Ekert, Paul G., Dolman, M. Emmy M.
Publicado 2023

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

por Meister, Michael T, Groot Koerkamp, Marian J A, de Souza, Terezinha, Breunis, Willemijn B, Frazer‐Mendelewska, Ewa, Brok, Mariël, DeMartino, Jeff, Manders, Freek, Calandrini, Camilla, Kerstens, Hinri H D, Janse, Alex, Dolman, M Emmy M, Eising, Selma, Langenberg, Karin P S, van Tuil, Marc, Knops, Rutger R G, van Scheltinga, Sheila Terwisscha, Hiemcke‐Jiwa, Laura S, Flucke, Uta, Merks, Johannes H M, van Noesel, Max M, Tops, Bastiaan B J, Hehir‐Kwa, Jayne Y, Kemmeren, Patrick, Molenaar, Jan J, van de Wetering, Marc, van Boxtel, Ruben, Drost, Jarno, Holstege, Frank C P
Publicado 2022