Re-Configuration of Sphingolipid Metabolism by Oncogenic Transformation

por Don, Anthony S., Lim, Xin Y., Couttas, Timothy A.
Publicado 2014

The major TMEM106B dementia risk allele affects TMEM106B protein levels and myelin lipid homeostasis in the ageing human hippocampus

por Lee, Jun Yup, Harney, Dylan, Kwok, John, Larance, Mark, Don, Anthony Simon
Publicado 2023

Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy

por Don, Anthony S, Hsiao, Jen-Hsiang T, Bleasel, Jonathan M, Couttas, Timothy A, Halliday, Glenda M, Kim, Woojin Scott
Publicado 2014

The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

por Lee, Jun Yup, Harney, Dylan J, Teo, Jonathan D, Kwok, John B, Sutherland, Greg T., Larance, Mark, Don, Anthony S
Publicado 2023

Exposure to solar ultraviolet radiation establishes a novel immune suppressive lipidome in skin-draining lymph nodes

por Tse, Benita C. Y., Ferguson, Angela L., Koay, Yen Chin, Grau, Georges E., Don, Anthony S., Byrne, Scott N.
Publicado 2023

Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations

por Marian, Oana C., Teo, Jonathan D., Lee, Jun Yup, Song, Huitong, Kwok, John B., Landin-Romero, Ramon, Halliday, Glenda, Don, Anthony S.
Publicado 2023

Disparate In Vivo Efficacy of FTY720 in Xenograft Models of Philadelphia Positive and Negative B-lineage Acute Lymphoblastic Leukemia

por Wallington-Beddoe, Craig T., Don, Anthony S., Hewson, John, Qiao, Qiao, Papa, Rachael A., Lock, Richard B., Bradstock, Kenneth F., Bendall, Linda J.
Publicado 2012

Correction: Disparate In Vivo Efficacy of FTY720 in Xenograft Models of Philadelphia Positive and Negative B-lineage Acute Lymphoblastic Leukemia

por Wallington-Beddoe, Craig T., Don, Anthony S., Hewson, John, Qiao, Qiao, Papa, Rachael A., Lock, Richard B., Bradstock, Kenneth F., Bendall, Linda J.
Publicado 2012

A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids

por Couttas, Timothy Andrew, Rustam, Yepy Hardi, Song, Huitong, Qi, Yanfei, Teo, Jonathan David, Chen, Jinbiao, Reid, Gavin Edmund, Don, Anthony Simon
Publicado 2020

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis

por Couttas, Timothy A, Kain, Nupur, Daniels, Benjamin, Lim, Xin Ying, Shepherd, Claire, Kril, Jillian, Pickford, Russell, Li, Hongyun, Garner, Brett, Don, Anthony S
Publicado 2014

Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma

por Gendron, David, Lemay, Anne-Marie, Tremblay, Claudine, Lai, Laetitia JA, Langlois, Anick, Bernatchez, Émilie, Flamand, Nicolas, Blanchet, Marie-Renée, Don, Anthony S, Bossé, Ynuk, Bissonnette, Élyse, Marsolais, David
Publicado 2015

Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice

por Chen, Jinbiao, Qi, Yanfei, Zhao, Yang, Kaczorowski, Dominik, Couttas, Timothy A., Coleman, Paul R., Don, Anthony S., Bertolino, Patrick, Gamble, Jennifer R., Vadas, Mathew A., Xia, Pu, McCaughan, Geoffrey W.
Publicado 2018

A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties

por Pitman, Melissa R., Powell, Jason A., Coolen, Carl, Moretti, Paul A.B., Zebol, Julia R., Pham, Duyen H., Finnie, John W., Don, Anthony S., Ebert, Lisa M., Bonder, Claudine S., Gliddon, Briony L., Pitson, Stuart M.
Publicado 2015

A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma

por Gendron, David R., Lecours, Pascale B., Lemay, Anne-Marie, Beaulieu, Marie-Josée, Huppé, Carole-Ann, Lee-Gosselin, Audrey, Flamand, Nicolas, Don, Anthony S., Bissonnette, Élyse, Blanchet, Marie-Renée, Laplante, Mathieu, Bourgoin, Sylvain G., Bossé, Ynuk, Marsolais, David
Publicado 2017

Ceramide Regulates Anti-Tumor Mechanisms of Erianin in Androgen-Sensitive and Castration-Resistant Prostate Cancers

por Trapika, I Gusti Md Gde Surya C., Liu, Xin Tracy, Chung, Long Hoa, Lai, Felcia, Xie, Chanlu, Zhao, Yang, Cui, Shaohui, Chen, Jinbiao, Tran, Collin, Wang, Qian, Zhang, Shubiao, Don, Anthony S., Li, George Qian, Hanrahan, Jane R., Qi, Yanfei
Publicado 2021

TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine

por Li, Yang Emma, Wang, Yichang, Du, Ximing, Zhang, Tizhong, Mak, Hoi Yin, Hancock, Sarah E., McEwen, Holly, Pandzic, Elvis, Whan, Renee M., Aw, Yvette Celine, Lukmantara, Ivan E., Yuan, Yiqiong, Dong, Xiuju, Don, Anthony, Turner, Nigel, Qi, Shiqian, Yang, Hongyuan
Publicado 2021

Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control

por Montgomery, Magdalene K., Bayliss, Jacqueline, Nie, Shuai, De Nardo, William, Keenan, Stacey N., Miotto, Paula M., Karimkhanloo, Hamzeh, Huang, Cheng, Schittenhelm, Ralf B., Don, Anthony S., Ryan, Andrew, Williamson, Nicholas A., Ooi, Geraldine J., Brown, Wendy A., Burton, Paul R., Parker, Benjamin L., Watt, Matthew J.
Publicado 2022

Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle

por Diaz-Vegas, Alexis, Madsen, Soren, Cooke, Kristen C., Carroll, Luke, Khor, Jasmine X. Y., Turner, Nigel, Lim, Xin Ying, Astore, Miro A., Morris, Jonathan, Don, Anthony, Garfield, Amanda, Zarini, Simona, Zemski Berry, Karin A., Ryan, Andrew, Bergman, Bryan C., Brozinick, Joseph T., James, David E., Burchfield, James G.
Publicado 2023

Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein

por Liu, Xin Tracy, Chung, Long Hoa, Liu, Da, Chen, Jinbiao, Huang, Yu, Teo, Jonathan D., Han, Xingxing Daisy, Zhao, Yinan, Guan, Fiona H. X., Tran, Collin, Lee, Jun Yup, Couttas, Timothy A., Liu, Ken, McCaughan, Geoffery W., Gorrell, Mark D., Don, Anthony S., Zhang, Shubiao, Qi, Yanfei
Publicado 2022

Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors

por Smith, Amanda M., Dun, Matthew D., Lee, Erwin M., Harrison, Celeste, Kahl, Richard, Flanagan, Hayley, Panicker, Nikita, Mashkani, Baratali, Don, Anthony S., Morris, Jonathan, Toop, Hamish, Lock, Richard B., Powell, Jason A., Thomas, Daniel, Guthridge, Mark A., Moore, Andrew, Ashman, Leonie K., Skelding, Kathryn A., Enjeti, Anoop, Verrills, Nicole M.
Publicado 2016