CD3-immunotoxin mediated depletion of T cells in lymphoid tissues of rhesus macaques

por Wang, Lan, Suryawanshi, Gajendra W., Kim, Shihyoung, Guan, Xin, Bonifacino, Aylin C., Metzger, Mark E., Donahue, Robert E., Kim, Sanggu, Chen, Irvin S.Y.
Publicado 2023

CD4+ levels control the odds of induction of humoral immune responses to tracer doses of therapeutic antibodies

por Srinivasula, Sharat, Gabriel, Erin, Kim, Insook, DeGrange, Paula, St Claire, Alexis, Mallow, Candace, Donahue, Robert E., Paik, Chang, Lane, H. C., Di Mascio, Michele
Publicado 2017

Total body irradiation must be delivered at high dose for efficient engraftment and tolerance in a rhesus stem cell gene therapy model

por Uchida, Naoya, Weitzel, R Patrick, Shvygin, Anna, Skala, Luke P, Raines, Lydia, Bonifacino, Aylin C, Krouse, Allen E, Metzger, Mark E, Donahue, Robert E, Tisdale, John F
Publicado 2016

Geographic clonal tracking in macaques provides insights into HSPC migration and differentiation

por Wu, Chuanfeng, Espinoza, Diego A., Koelle, Samson J., Potter, E. Lake, Lu, Rong, Li, Brian, Yang, Di, Fan, Xing, Donahue, Robert E., Roederer, Mario, Dunbar, Cynthia E.
Publicado 2018

Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders

por Uchida, Naoya, Hsieh, Matthew M., Raines, Lydia, Haro-Mora, Juan J., Demirci, Selami, Bonifacino, Aylin C., Krouse, Allen E., Metzger, Mark E., Donahue, Robert E., Tisdale, John F.
Publicado 2019

Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number

por Uchida, Naoya, Evans, Molly E, Hsieh, Matthew M, Bonifacino, Aylin C, Krouse, Allen E, Metzger, Mark E, Sellers, Stephanie E, Dunbar, Cynthia E, Donahue, Robert E, Tisdale, John F
Publicado 2013

Clonal tracking of erythropoiesis in rhesus macaques

por Fan, Xing, Wu, Chuanfeng, Truitt, Lauren L., Espinoza, Diego A., Sellers, Stephanie, Bonifacino, Aylin, Zhou, Yifan, Cordes, Stefan F., Krouse, Allen, Metzger, Mark, Donahue, Robert E., Lu, Rong, Dunbar, Cynthia E.
Publicado 2020

Pharmacological Modulation of Humoral Immunity in a Nonhuman Primate Model of AAV Gene Transfer for Hemophilia B

por Mingozzi, Federico, Chen, Yifeng, Murphy, Samuel L, Edmonson, Shyrie C, Tai, Alex, Price, Sandra D, Metzger, Mark E, Zhou, Shangzhen, Wright, J Fraser, Donahue, Robert E, Dunbar, Cynthia E, High, Katherine A
Publicado 2012

Impact of CMV Infection on Natural Killer Cell Clonal Repertoire in CMV-Naïve Rhesus Macaques

por Truitt, Lauren L., Yang, Di, Espinoza, Diego A., Fan, Xing, Ram, Daniel R., Moström, Matilda J., Tran, Dollnovan, Sprehe, Lesli M., Reeves, R. Keith, Donahue, Robert E., Kaur, Amitinder, Dunbar, Cynthia E., Wu, Chuanfeng
Publicado 2019

Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity

por Yabe, Idalia M., Truitt, Lauren L., Espinoza, Diego A., Wu, Chuanfeng, Koelle, Samson, Panch, Sandhya, Corat, Marcus A.F., Winkler, Thomas, Yu, Kyung-Rok, Hong, So Gun, Bonifacino, Aylin, Krouse, Allen, Metzger, Mark, Donahue, Robert E., Dunbar, Cynthia E.
Publicado 2018

Comparative engraftment and clonality of macaque HSPCs expanded on human umbilical vein endothelial cells versus non-expanded cells

por Srivastava, Sandeep K., Truitt, Lauren L., Wu, Chuanfeng, Glaser, Adam, Nolan, Daniel J., Ginsberg, Michael, Espinoza, Diego A., Koelle, Samson, Yabe, Idalia M., Yu, Kyung-Rok, Hong, Sogun, Sellers, Stephanie, Krouse, Allen, Bonifacino, Aylin, Metzger, Mark, Dagur, Pradeep K., Donahue, Robert E., Dunbar, Cynthia E., Panch, Sandhya R.
Publicado 2021

Preclinical evaluation for engraftment of CD34(+) cells gene-edited at the sickle cell disease locus in xenograft mouse and non-human primate models

por Uchida, Naoya, Li, Linhong, Nassehi, Tina, Drysdale, Claire M., Yapundich, Morgan, Gamer, Jackson, Haro-Mora, Juan J., Demirci, Selami, Leonard, Alexis, Bonifacino, Aylin C., Krouse, Allen E., Linde, N. Seth, Allen, Cornell, Peshwa, Madhusudan V., De Ravin, Suk See, Donahue, Robert E., Malech, Harry L., Tisdale, John F.
Publicado 2021

Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation

por Essawi, Khaled, Hakami, Waleed, Naeem Khan, Muhammad Behroz, Martin, Reid, Zeng, Jing, Chu, Rebecca, Uchida, Naoya, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel S., Donahue, Robert E., Blobel, Gerd A., Gerdemann, Ulrike, Kean, Leslie S., Maitland, Stacy A., Wolfe, Scot A., Metais, Jean-Yves, Gottschalk, Stephen, Bauer, Daniel E., Tisdale, John F., Demirci, Selami
Publicado 2023

Fertility-preserving myeloablative conditioning using single-dose CD117 antibody-drug conjugate in a rhesus gene therapy model

por Uchida, Naoya, Stasula, Ulana, Demirci, Selami, Germino-Watnick, Paula, Hinds, Malikiya, Le, Anh, Chu, Rebecca, Berg, Alexander, Liu, Xiong, Su, Ling, Wu, Xiaolin, Krouse, Allen E., Linde, N. Seth, Bonifacino, Aylin, Hong, So Gun, Dunbar, Cynthia E., Lanieri, Leanne, Bhat, Anjali, Palchaudhuri, Rahul, Bennet, Bindu, Hoban, Megan, Bertelsen, Kirk, Olson, Lisa M., Donahue, Robert E., Tisdale, John F.
Publicado 2023

Forced enhancer-promoter rewiring to alter gene expression in animal models

por Peslak, Scott A., Demirci, Selami, Chandra, Vemika, Ryu, Byoung, Bhardwaj, Saurabh K., Jiang, Jing, Rupon, Jeremy W., Throm, Robert E., Uchida, Naoya, Leonard, Alexis, Essawi, Khaled, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel S., Donahue, Robert E., Ferrara, Francesca, Wielgosz, Matthew, Abdulmalik, Osheiza, Hamagami, Nicole, Germino-Watnick, Paula, Le, Anh, Chu, Rebecca, Hinds, Malikiya, Weiss, Mitchell J., Tong, Wei, Tisdale, John F., Blobel, Gerd A.
Publicado 2023