In vivo profiling of metastatic double knockouts through CRISPR-Cpf1 screens

por Chow, Ryan D., Wang, Guangchuan, Ye, Lupeng, Codina, Adan, Kim, Hyunu Ray, Shen, Li, Dong, Matthew B., Errami, Youssef, Chen, Sidi
Publicado 2019

Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System

por Zhang, Li, Park, Jonathan J, Dong, Matthew B, Arsala, Deanna, Xia, Shengqian, Chen, Jianhai, Sosa, Dylan, Atlas, Jared E, Long, Manyuan, Chen, Sidi
Publicado 2023

Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening

por Wang, Guangchuan, Chow, Ryan D., Ye, Lupeng, Guzman, Christopher D., Dai, Xiaoyun, Dong, Matthew B., Zhang, Feng, Sharp, Phillip A., Platt, Randall J., Chen, Sidi
Publicado 2018

Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9

por Lee, Linda M., Ji, Ming, Sinha, Meenal, Dong, Matthew B., Ren, Xin, Wang, Yanli, Lowell, Clifford A., Ghosh, Sankar, Locksley, Richard M., DeFranco, Anthony L.
Publicado 2016

Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA

por Yuan, Shuai, Peng, Lei, Park, Jonathan J., Hu, Yingxia, Devarkar, Swapnil C., Dong, Matthew B., Shen, Qi, Wu, Shenping, Chen, Sidi, Lomakin, Ivan B., Xiong, Yong
Publicado 2020

In vivo CRISPR screening in CD8 T cells with AAV-Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma

por Ye, Lupeng, Park, Jonathan J., Dong, Matthew B., Yang, Quanjun, Chow, Ryan D., Peng, Lei, Du, Yaying, Guo, Jianjian, Dai, Xiaoyun, Wang, Guangchuan, Errami, Youssef, Chen, Sidi
Publicado 2019

Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species

por Peng, Lei, Fang, Zhenhao, Renauer, Paul A., McNamara, Andrew, Park, Jonathan J., Lin, Qianqian, Zhou, Xiaoyu, Dong, Matthew B., Zhu, Biqing, Zhao, Hongyu, Wilen, Craig B., Chen, Sidi
Publicado 2022

Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2

por Peng, Lei, Renauer, Paul A., Ökten, Arya, Fang, Zhenhao, Park, Jonathan J., Zhou, Xiaoyu, Lin, Qianqian, Dong, Matthew B., Filler, Renata, Xiong, Qiancheng, Clark, Paul, Lin, Chenxiang, Wilen, Craig B., Chen, Sidi
Publicado 2022

Multiplexed activation of endogenous genes by CRISPRa elicits potent anti-tumor immunity

por Wang, Guangchuan, Chow, Ryan D., Bai, Zhigang, Zhu, Lvyun, Errami, Youssef, Dai, Xiaoyun, Dong, Matthew B., Ye, Lupeng, Zhang, Xiaoya, Renauer, Paul A., Park, Jonathan J., Shen, Li, Ye, Hanghui, Fuchs, Charles S., Chen, Sidi
Publicado 2019

AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

por Chow, Ryan D., Guzman, Christopher D., Wang, Guangchuan, Schmidt, Florian, Youngblood, Mark W., Ye, Lupeng, Errami, Youssef, Dong, Matthew B., Martinez, Michael A., Zhang, Sensen, Renauer, Paul, Bilguvar, Kaya, Gunel, Murat, Sharp, Phillip A., Zhang, Feng, Platt, Randall J., Chen, Sidi
Publicado 2017

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617

por Peng, Lei, Hu, Yingxia, Mankowski, Madeleine C., Ren, Ping, Chen, Rita E., Wei, Jin, Zhao, Min, Li, Tongqing, Tripler, Therese, Ye, Lupeng, Chow, Ryan D., Fang, Zhenhao, Wu, Chunxiang, Dong, Matthew B., Cook, Matthew, Wang, Guilin, Clark, Paul, Nelson, Bryce, Klein, Daryl, Sutton, Richard, Diamond, Michael S., Wilen, Craig B., Xiong, Yong, Chen, Sidi
Publicado 2021

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617

por Peng, Lei, Hu, Yingxia, Mankowski, Madeleine C., Ren, Ping, Chen, Rita E., Wei, Jin, Zhao, Min, Li, Tongqing, Tripler, Therese, Ye, Lupeng, Chow, Ryan D., Fang, Zhenhao, Wu, Chunxiang, Dong, Matthew B., Cook, Matthew, Wang, Guilin, Clark, Paul, Nelson, Bryce, Klein, Daryl, Sutton, Richard, Diamond, Michael S., Wilen, Craig B., Xiong, Yong, Chen, Sidi
Publicado 2022