Gut-on-a-Chip Research for Drug Development: Implications of Chip Design on Preclinical Oral Bioavailability or Intestinal Disease Studies

por Donkers, Joanne M., van der Vaart, Jamie I., van de Steeg, Evita
Publicado 2023

Mechanistic insights into the inhibition of NTCP by myrcludex B

por Donkers, Joanne M., Appelman, Monique D., van de Graaf, Stan F.J.
Publicado 2019

The Progress of Intestinal Epithelial Models from Cell Lines to Gut-On-Chip

por Rahman, Shafaque, Ghiboub, Mohammed, Donkers, Joanne M., van de Steeg, Evita, van Tol, Eric A. F., Hakvoort, Theodorus B. M., de Jonge, Wouter J.
Publicado 2021

A practice-changing culture method relying on shaking substantially increases mitochondrial energy metabolism and functionality of human liver cell lines

por Adam, Aziza A. A., van der Mark, Vincent A., Donkers, Joanne M., Wildenberg, Manon E., Oude Elferink, Ronald P. J., Chamuleau, Robert A. F. M., Hoekstra, Ruurdtje
Publicado 2018

Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP

por Donkers, Joanne M., Zehnder, Benno, van Westen, Gerard J. P., Kwakkenbos, Mark J., IJzerman, Adriaan P., Oude Elferink, Ronald P. J., Beuers, Ulrich, Urban, Stephan, van de Graaf, Stan F. J.
Publicado 2017

Inhibition of Hepatic Bile Acid Uptake by Myrcludex B Promotes Glucagon-Like Peptide-1 Release and Reduces Obesity

por Donkers, Joanne M., Roscam Abbing, Reinout L.P., van Weeghel, Michel, Levels, Johannes H.M., Boelen, Anita, Schinkel, Alfred H., Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Publicado 2020

Blocking Sodium‐Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice

por Roscam Abbing, Reinout L.P., Slijepcevic, Davor, Donkers, Joanne M., Havinga, Rick, Duijst, Suzanne, Paulusma, Coen C., Kuiper, Johan, Kuipers, Folkert, Groen, Albert K., Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Publicado 2019

NTCP deficiency in mice protects against obesity and hepatosteatosis

por Donkers, Joanne M., Kooijman, Sander, Slijepcevic, Davor, Kunst, Roni F., Roscam Abbing, Reinout L.P., Haazen, Lizette, de Waart, Dirk R., Levels, Johannes H.M., Schoonjans, Kristina, Rensen, Patrick C.N., Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Publicado 2019

Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal s...

por Slijepcevic, Davor, Roscam Abbing, Reinout L.P., Katafuchi, Takeshi, Blank, Antje, Donkers, Joanne M., van Hoppe, Stéphanie, de Waart, Dirk. R., Tolenaars, Dagmar, van der Meer, Jonathan H.M., Wildenberg, Manon, Beuers, Ulrich, Oude Elferink, Ronald P.J., Schinkel, Alfred H., van de Graaf, Stan F.J.
Publicado 2017