Single‐Cell Integration of BMD GWAS Results Prioritize Candidate Genes Influencing Age‐Related Bone Loss

por Doolittle, Madison L., Khosla, Sundeep, Saul, Dominik
Publicado 2023

MicroRNA‐19a‐3p Decreases with Age in Mice and Humans and Inhibits Osteoblast Senescence

por Kaur, Japneet, Saul, Dominik, Doolittle, Madison L., Farr, Joshua N., Khosla, Sundeep, Monroe, David G.
Publicado 2023

Identification of a suitable endogenous control miRNA in bone aging and senescence

por Kaur, Japneet, Saul, Dominik, Doolittle, Madison L., Rowsey, Jennifer L., Vos, Stephanie J., Farr, Joshua N., Khosla, Sundeep, Monroe, David G.
Publicado 2022

Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass

por Doolittle, Madison L., Calabrese, Gina M., Mesner, Larry D., Godfrey, Dana A., Maynard, Robert D., Ackert-Bicknell, Cheryl L., Farber, Charles R.
Publicado 2020

Modulation of fracture healing by the transient accumulation of senescent cells

por Saul, Dominik, Monroe, David G, Rowsey, Jennifer L, Kosinsky, Robyn Laura, Vos, Stephanie J, Doolittle, Madison L, Farr, Joshua N, Khosla, Sundeep
Publicado 2021

Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

por Doolittle, Madison L., Saul, Dominik, Kaur, Japneet, Rowsey, Jennifer L., Vos, Stephanie J., Pavelko, Kevin D., Farr, Joshua N., Monroe, David G., Khosla, Sundeep
Publicado 2023

Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

por Doolittle, Madison L., Saul, Dominik, Kaur, Japneet, Rowsey, Jennifer L., Vos, Stephanie J., Pavelko, Kevin D., Farr, Joshua N., Monroe, David G., Khosla, Sundeep
Publicado 2023

Modest Effects of Osteoclast‐Specific ERα Deletion after Skeletal Maturity

por Doolittle, Madison L., Eckhardt, Brittany A., Vos, Stephanie J., Grain, Sarah, Rowsey, Jennifer L., Ruan, Ming, Saul, Dominik, Farr, Joshua N., Weivoda, Megan M., Khosla, Sundeep, Monroe, David G.
Publicado 2023

Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity

por Chandra, Abhishek, Lagnado, Anthony B., Farr, Joshua N., Doolittle, Madison, Tchkonia, Tamara, Kirkland, James L., LeBrasseur, Nathan K., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Passos, João F., Monroe, David G., Pignolo, Robert J., Khosla, Sundeep
Publicado 2022

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

por Samakkarnthai, Parinya, Saul, Dominik, Zhang, Lei, Aversa, Zaira, Doolittle, Madison L., Sfeir, Jad G., Kaur, Japneet, Atkinson, Elizabeth J., Edwards, James R., Russell, Graham G., Pignolo, Robert J., Kirkland, James L., Tchkonia, Tamar, Niedernhofer, Laura J., Monroe, David G., Lebrasseur, Nathan K., Farr, Joshua N., Robbins, Paul D., Khosla, Sundeep
Publicado 2023

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

por Saul, Dominik, Kosinsky, Robyn Laura, Atkinson, Elizabeth J., Doolittle, Madison L., Zhang, Xu, LeBrasseur, Nathan K., Pignolo, Robert J., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Jurk, Diana, Passos, João F., Hickson, LaTonya J., Xue, Ailing, Monroe, David G., Tchkonia, Tamara, Kirkland, James L., Farr, Joshua N., Khosla, Sundeep
Publicado 2022

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

por Farr, Joshua N., Saul, Dominik, Doolittle, Madison L., Kaur, Japneet, Rowsey, Jennifer L., Vos, Stephanie J., Froemming, Mitchell N., Lagnado, Anthony B., Zhu, Yi, Weivoda, Megan, Ikeno, Yuji, Pignolo, Robert J., Niedernhofer, Laura J., Robbins, Paul D., Jurk, Diana, Passos, João F., LeBrasseur, Nathan K., Tchkonia, Tamara, Kirkland, James L., Monroe, David G., Khosla, Sundeep
Publicado 2023

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

por Lagnado, Anthony, Leslie, Jack, Ruchaud‐Sparagano, Marie‐Helene, Victorelli, Stella, Hirsova, Petra, Ogrodnik, Mikolaj, Collins, Amy L, Vizioli, Maria Grazia, Habiballa, Leena, Saretzki, Gabriele, Evans, Shane A, Salmonowicz, Hanna, Hruby, Adam, Geh, Daniel, Pavelko, Kevin D, Dolan, David, Reeves, Helen L, Grellscheid, Sushma, Wilson, Colin H, Pandanaboyana, Sanjay, Doolittle, Madison, von Zglinicki, Thomas, Oakley, Fiona, Gallage, Suchira, Wilson, Caroline L, Birch, Jodie, Carroll, Bernadette, Chapman, James, Heikenwalder, Mathias, Neretti, Nicola, Khosla, Sundeep, Masuda, Claudio Akio, Tchkonia, Tamar, Kirkland, James L, Jurk, Diana, Mann, Derek A, Passos, João F
Publicado 2021