Immunological considerations for SARS-CoV-2 human challenge studies

por Douglas, Alexander D., Hill, Adrian V. S.
Publicado 2020

Challenges of assessing the clinical efficacy of asexual blood-stage Plasmodium falciparum malaria vaccines

por Sheehy, Susanne H, Douglas, Alexander D, Draper, Simon J
Publicado 2013

Lyophilization to enable distribution of ChAdOx1 and ChAdOx2 adenovirus-vectored vaccines without refrigeration

por Zhang, Cheng, Berg, Adam, Joe, Carina C. D., Dalby, Paul A., Douglas, Alexander D.
Publicado 2023

STING-pathway modulation to enhance the immunogenicity of adenoviral-vectored vaccines

por Padron-Regalado, Eriko, Ulaszewska, Marta, Douglas, Alexander D., Hill, Adrian V. S., Spencer, Alexandra J.
Publicado 2022

Tailoring subunit vaccine immunogenicity: Maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium fa...

por Douglas, Alexander D., de Cassan, Simone C., Dicks, Matthew D.J., Gilbert, Sarah C., Hill, Adrian V.S., Draper, Simon J.
Publicado 2010

Stability of Chimpanzee Adenovirus Vectored Vaccines (ChAdOx1 and ChAdOx2) in Liquid and Lyophilised Formulations

por Berg, Adam, Wright, Daniel, Dulal, Pawan, Stedman, Anna, Fedosyuk, Sofiya, Francis, Michael J., Charleston, Bryan, Warimwe, George M., Douglas, Alexander D.
Publicado 2021

Germinal Center B Cell and T Follicular Helper Cell Responses to Viral Vector and Protein-in-Adjuvant Vaccines

por Wang, Chuan, Hart, Matthew, Chui, Cecilia, Ajuogu, Augustine, Brian, Iona J., de Cassan, Simone C., Borrow, Persephone, Draper, Simon J., Douglas, Alexander D.
Publicado 2016

Structure of trimeric pre-fusion rabies virus glycoprotein in complex with two protective antibodies

por Ng, Weng M., Fedosyuk, Sofiya, English, Solomon, Augusto, Gilles, Berg, Adam, Thorley, Luke, Haselon, Anna-Sophie, Segireddy, Rameswara R., Bowden, Thomas A., Douglas, Alexander D.
Publicado 2022

Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome

por Llewellyn, David, de Cassan, Simone C., Williams, Andrew R., Douglas, Alexander D., Forbes, Emily K., Adame-Gallegos, Jaime R., Shi, Jianguo, Pleass, Richard J., Draper, Simon J.
Publicado 2014

Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies

por Wright, Katherine E., Hjerrild, Kathryn A., Bartlett, Jonathan, Douglas, Alexander D., Jin, Jing, Brown, Rebecca E., Illingworth, Joseph J., Ashfield, Rebecca, Clemmensen, Stine B., de Jongh, Willem A., Draper, Simon J., Higgins, Matthew K.
Publicado 2014

Characterisation of factors contributing to the performance of nonwoven fibrous matrices as substrates for adenovirus vectored vaccine stabilisation

por Dulal, Pawan, Gharaei, Robabeh, Berg, Adam, Walters, Adam A., Hawkins, Nicholas, Claridge, Tim D. W., Kowal, Katarzyna, Neill, Steven, Ritchie, Adam J., Ashfield, Rebecca, Hill, Adrian V. S., Tronci, Giuseppe, Russell, Stephen J., Douglas, Alexander D.
Publicado 2021

Publisher Correction: Characterisation of factors contributing to the performance of nonwoven fibrous matrices as substrates for adenovirus vectored vaccine stabilisation

por Dulal, Pawan, Gharaei, Robabeh, Berg, Adam, Walters, Adam A., Hawkins, Nicholas, Claridge, Tim D. W., Kowal, Katarzyna, Neill, Steven, Ritchie, Adam J., Ashfield, Rebecca, Hill, Adrian V. S., Tronci, Giuseppe, Russell, Stephen J., Douglas, Alexander D.
Publicado 2021

A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose pre-exposure prophylaxis

por Wang, Chuan, Dulal, Pawan, Zhou, Xiangyang, Xiang, Zhiquan, Goharriz, Hooman, Banyard, Ashley, Green, Nicky, Brunner, Livia, Ventura, Roland, Collin, Nicolas, Draper, Simon J., Hill, Adrian V. S., Ashfield, Rebecca, Fooks, Anthony R., Ertl, Hildegund C., Douglas, Alexander D.
Publicado 2018

Preclinical Assessment of Viral Vectored and Protein Vaccines Targeting the Duffy-Binding Protein Region II of Plasmodium Vivax

por de Cassan, Simone C., Shakri, A. Rushdi, Llewellyn, David, Elias, Sean C., Cho, Jee Sun, Goodman, Anna L., Jin, Jing, Douglas, Alexander D., Suwanarusk, Rossarin, Nosten, François H., Rénia, Laurent, Russell, Bruce, Chitnis, Chetan E., Draper, Simon J.
Publicado 2015

Standardization of the antibody-dependent respiratory burst assay with human neutrophils and Plasmodium falciparum malaria

por Llewellyn, David, Miura, Kazutoyo, Fay, Michael P., Williams, Andrew R., Murungi, Linda M., Shi, Jianguo, Hodgson, Susanne H., Douglas, Alexander D., Osier, Faith H., Fairhurst, Rick M., Diakite, Mahamadou, Pleass, Richard J., Long, Carole A., Draper, Simon J.
Publicado 2015

Simian adenovirus vector production for early-phase clinical trials: A simple method applicable to multiple serotypes and using entirely disposable product-contact components

por Fedosyuk, Sofiya, Merritt, Thomas, Peralta-Alvarez, Marco Polo, Morris, Susan J, Lam, Ada, Laroudie, Nicolas, Kangokar, Anilkumar, Wright, Daniel, Warimwe, George M, Angell-Manning, Phillip, Ritchie, Adam J, Gilbert, Sarah C, Xenopoulos, Alex, Boumlic, Anissa, Douglas, Alexander D
Publicado 2019

Enhancing Blockade of Plasmodium falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies against PfRH5 and Other Merozoite Antigens

por Williams, Andrew R., Douglas, Alexander D., Miura, Kazutoyo, Illingworth, Joseph J., Choudhary, Prateek, Murungi, Linda M., Furze, Julie M., Diouf, Ababacar, Miotto, Olivo, Crosnier, Cécile, Wright, Gavin J., Kwiatkowski, Dominic P., Fairhurst, Rick M., Long, Carole A., Draper, Simon J.
Publicado 2012

Comparison of Modeling Methods to Determine Liver-to-blood Inocula and Parasite Multiplication Rates During Controlled Human Malaria Infection

por Douglas, Alexander D., Edwards, Nick J., Duncan, Christopher J. A., Thompson, Fiona M., Sheehy, Susanne H., O'Hara, Geraldine A., Anagnostou, Nicholas, Walther, Michael, Webster, Daniel P., Dunachie, Susanna J., Porter, David W., Andrews, Laura, Gilbert, Sarah C., Draper, Simon J., Hill, Adrian V. S., Bejon, Philip
Publicado 2013

Safety and immunogenicity of a simian-adenovirus-vectored rabies vaccine: an open-label, non-randomised, dose-escalation, first-in-human, single-centre, phase 1 clinical trial

por Jenkin, Daniel, Ritchie, Adam J, Aboagye, Jeremy, Fedosyuk, Sofiya, Thorley, Luke, Provstgaad-Morys, Samuel, Sanders, Helen, Bellamy, Duncan, Makinson, Rebecca, Xiang, Zhi Quan, Bolam, Emma, Tarrant, Richard, Lopez, Fernando Ramos, Platt, Abigail, Poulton, Ian, Green, Catherine, Ertl, Hildegund C J, Ewer, Katie J, Douglas, Alexander D
Publicado 2022

The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment

por Goodman, Anna L., Forbes, Emily K., Williams, Andrew R., Douglas, Alexander D., de Cassan, Simone C., Bauza, Karolis, Biswas, Sumi, Dicks, Matthew D. J., Llewellyn, David, Moore, Anne C., Janse, Chris J., Franke-Fayard, Blandine M., Gilbert, Sarah C., Hill, Adrian V. S., Pleass, Richard J., Draper, Simon J.
Publicado 2013